Showing papers in "European Journal of Cancer and Clinical Oncology in 1987"

TL;DR: The finding of extractable amounts of DNA in the plasma of 27% of the investigated cancer patients, and its absence from the controls, suggests some correlation with malignancy.

TL;DR: A significant increase in peripheral blast cells was observed, whereas bone marrow cytologies before and after treatment did not reveal a significant change in blasts, and the apparent lack of clinical efficacy may be explained by the low plasma levels of sodium butyrate due to its short half-life in vivo.

TL;DR: A higher response rate with less myelosuppression suggests that IFOS may have advantages over CYCLO in combination therapy, and serious infections occurred in approx.

TL;DR: In this paper, a shift in the prooxidant/antioxidant balance in favor of the former has been identified as a normal attribute of aerobic life, and structural damage to organic compounds of a wide variety (DNA, proteins, carbohydrates and lipids) may occur as a consequence of oxidative reactions.

TL;DR: In this model system, estrogen withdrawal and antiestrogen therapy work primarily by cytostatic rather than cytocidal mechanisms, suggesting the conversion to hormone independence.

TL;DR: Reinduction at relapse, after short term chemotherapy and a treatment-free interval, with the induction regimen is an effective second line treatment in patients with an initial CR and a first response duration of greater than 34 weeks.

TL;DR: The use of equimolar doses of adriamycin and EPI in advanced soft tissue sarcoma produced response rates which did not differ significantly and were only slightly in favour of ADM, however, this was achieved at the expense of higher toxicity.

TL;DR: It is concluded that the DNA analysis of tumour cells is a promising method for the estimation of prognosis in breast cancer patients.

TL;DR: In the dead cells, the ATP level was extensively decreased, but the succinate dehydrogenase activity remained at a level of 24% of that of mitomycin C-untreated viable cells, even on day 3, which better reflected the cell viability.

TL;DR: When human breast cancer-derived MCF-7 cells were maintained in low estrogen medium (phenol red-free), the cells adapted to grow without added estrogen, but growth could be inhibited by antiestrogen in the medium.

TL;DR: DAC given in this dose and schedule is devoid of antitumour activity in adult patients with these refractory types of carcinomas, and one single partial remission was seen in a patient with malignant melanoma.

TL;DR: When induction chemotherapy has been effective and of short duration, the same chemotherapy can be attempted again with success at relapse and it may affect survival of relapsing small cell lung cancer patients.

TL;DR: Three new monoclonal anti-cytokeratin antibodies potentially useful in cancer research and clinical diagnosis have been evaluated in immuno-histochemistry on cryostat sections of a broad variety of normal human tissues.

TL;DR: It is confirmed that smoking is less frequent in cases hospitalized for endometrial cancer than in a comparison group of patients with non-smoking-related acute conditions, perhaps explained in terms of reduced estrogen levels in smokers.

TL;DR: Flavone acetic acid, an antitumour drug at present undergoing clinical trial for cancer treatment, has been found to activate natural killer cell activity in spleen cells of mice following in vivo treatment at doses of 45-330 mg/kg, comparable to that of the interferon inducer polyinosinic acid-polycytidylic acid.

TL;DR: The extent of embolization of different sized radioactive microspheres in experimental tumours and the homogeneity of their distribution in normal liver was examined in 25 rats and as microsphere diameter increased from 15 to 50 microns, micro Spheres lodged more evenly throughout the liver substance.

TL;DR: The ever-widening gap between the increasing incidence rate and the declining mortality rate, particularly apparent in the high-risk age group 15-44, indicates an improving prognosis for patients with this malignancy in Scotland.

TL;DR: It is suggested that consideration should be given to replacing the conventional limited/extensive disease staging system with a simpler system along the lines of this work.

TL;DR: A survey to determine the occurrence of ochratoxin A in human blood was conducted in affected and unaffected areas of Bulgaria, where both diseases are prevalent.

TL;DR: If proteases could be proved to play a role in the spread of human cancers, inhibition of these enzymes could open up new therapeutic approaches for the control of malignancy.

TL;DR: A mathematical model incorporating descriptions of tumour growth kinetics and the effects of cytotoxic chemotherapy on established tumours, is presented, intended to be an aid to clinicians designing new chemotherapy programmes for diseases in which progress has been disappointing.

TL;DR: The data indicate that the pathogenesis of ductal breast cancer may, in a substantial proportion of cases, involve unmasking of a recessive locus on chromosome 13 and suggest the involvement of such a locus in heritable forms of this disease.

TL;DR: Persistence of platinum was demonstrated in tissues removed at autopsy from a patient who had received carboplatin 14 days earlier, and highest platinum levels were found in the liver, kidney, skin and small cell lung tumour.

TL;DR: Data demonstrate that tamoxifen functions as a biological response modifier in post-menopausal stage I breast cancer patients and a statistically significant increase in NK activity was demonstrated.

TL;DR: The authors conclude both therapies were of limited efficacy in the treatment of ACUP patients and emphasize that only symptomatic patients should be considered for such therapies.

TL;DR: If screening detects tumours with a different natural history to that of those which surface clinically, this is not reflected in the relationship between tumour size and lymph node metastases, according to a randomized trial of breast cancer screening with mammography.

TL;DR: Cytofluorometric analysis showed that the growth inhibition of GA is the result of inhibition of the transfer from G1 to S phase.

TL;DR: An increased frequency of thyroid autoantibodies in euthyroid patients with breast cancer compared with healthy controls is found suggesting a possible relation between this disease and autoimmune thyroid disease.