Showing papers in "Experimental Gerontology in 1982"

TL;DR: The statistical analysis revealed that the values of the coefficient of variation generally increased with advancing age and increased significantly in senile kidneys.

TL;DR: There is a direct effect of age on thesolubility of collagen from human tissues, and that based on solubility, cartilage collagen ages faster than dura collagen, with skin undergoing the slowest relative aging, support previous observations indicating that collagen from individuals with diabetes mellitus undergoes accelerated aging.

TL;DR: The results suggest that the life span of C. elegans is rigidly determined by somatic cells and markedly influenced by the effects of temperature on the cells during the post-mitotic state.

TL;DR: The activities of ornithine decarboxylase (ODC) on the soluble and nuclear fractions of the cerebral cortex, heart and lungs of 4- (young), 38- and 85-week (old) male rats were studied.

TL;DR: The average cell cycle time was prolonged in Werner's syndrome cells due to changes in the duration of S phase, and the rate of DNA elongation was examined using alkaline sucrose gradient sedimentation.

TL;DR: Blackcurrant juice extract, containing a mixture of flavonoids in addition to quercetin, prolonged significantly the life span of the 'older dying' females and the significance of these results vis-a-vis aging mechanisms and the dietary intake of quercETin is discussed.

TL;DR: Dietary restriction of a type which may be described as “undernutrition without malnutrition” raises splenic PHA response capacity at least in part by increasing the proportion of PHA-responsive T cells.

TL;DR: Qualitative studies revealed a progressive increase in the intracellular lipofuscin pigment accumulation with advancing age and these pigment granules were found to congregate in mass in nerve cells of old individuals.

TL;DR: Physiological and behavioral measurements were made in a cohort of 29-month-old male C57BL/6J mice to determine whether any correlated significantly with lifespan, and significant linear relationships with lifespan were found among the physiological measures.

TL;DR: There was an increase both in the mean lifespan and in the length of the reproductive period in this rotifer when dietary restriction was imposed by increasing the interval between feeding times.

TL;DR: The results suggest that the decrease in delta-aminolevulinic acid synthase activity seen with age may be due to a decrease in the synthesis of mitochondrial inner membrane proteins.

TL;DR: The change in fluidity of the hepatic microsomal membrane with age may account for some of the observed changes in membrane-bound mixed function oxidase activities with age.

TL;DR: The thymus of the teleost fish Oryzias latipes is a paired structure found at the dorsoposterior part of the gill chamber that displays atrophy during aging, and theThymus involution continues until 5 years of age.

TL;DR: Results suggest that in the intact rats during aging: (1) the synthesis of VP in the HT may be reduced; (2) the storage ofVP in the NH is not impaired; and (3) the undetectable plasma VP concentration may reflect either reduced VP release or increased degradation.

TL;DR: There has been no change with age in the fundamental mechanism by which carrier, sodium, and GABA interact in the process of transport, however, quantitative changes were found to occur with age both in initial velocity of uptake and in those constants which quantitate the model.

TL;DR: The results suggest that aging CBA mice present a profile of altered hormone-receptor interaction which is only partly dependent on ovarian steroids.

TL;DR: Error theories are exerting a profound influence on the study of aging because they offer a coherent and simple explanation for the cause of senescent death as discussed by the authors, however its experimental testing is not a straightforward matter.

TL;DR: There is an age-associated effect in the cardiovascular response to change in posture in healthy people that resembles that found in congestive cardiac failure.

TL;DR: It is concluded that the triggering mechanism of Na+, K+-ATPase induced by PHA occurs adequately in early stimulated PBL from old subjects, and digoxine sensitive structures work freely during PHA-induced lymphocyte proliferation in aging, thereby supporting further arguments for adequate Na+,K+- ATPase activity.

TL;DR: Age had no significant effect on the absorption of vitamins A and D in female Wistar rats, and isotope in feces collected during this time was determined and subtracted from total dose.

TL;DR: Plasma and pituitary concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (Prl) were determined by radioimmunoassay in young and aged CD-1 and C57BL/6 mice one month after ovariectomy.

TL;DR: Gangliosides of human diploid fibroblast, TIG-1, derived from fetal lung were analyzed during cell aging and found that lipid-bound sialic acid per mg protein was twofold higher than the other passages.

TL;DR: This scaling of the annual increase in mortality rate of eutherian mammals scales very similar to that for psysiological time scales in general, M 1 4 , suggesting that the ageing process may be an integral part of the physiological lifespan.

TL;DR: Though in starved controls there was a total absence of glycogen granules, and a striking shrinkage and densification of mitochondria, TCA to a large extent protected muscle cells from these effects of starvation, and Electron microscopic investigation of wing muscle showed that 0.3% TCA had a protective effect on cellular fine structure.

TL;DR: Bomb calorimetry measurements were made on dried whole body samples of N. guentheri in an attempt to detect the effect of age induced protein crosslinking, and the results show a clear decrease in body energy with increasing age.

TL;DR: Histopathological and autofluorescence investigations revealed an increase of lipofuscin pigment accumulation in old animals and a significant increase in the percentage of pigmented nerve cells and the Percentage of cytoplasmic areas occupied by lipofuskin pigment granules with advancing age.

TL;DR: The synaptosomal fraction obtained from the motor area of the cerebral cortex of normocapnic, normoxic or hypoxic "young adult," "mature" and "senescent" beagle dogs is incubated and analyzed for ATP, ADP, AMP, creatine phosphate, pyruvate and lactate, showing a quite broad, age-independent spectrum of action.

TL;DR: The intestinal absorption of doses of vitamin B12 and of niacin was examined in 6, 12, and 24 months old female Wistar rats and Absorption of the two vitamins was not influenced by the age of the animals.

TL;DR: The results suggest that the control of the biosynthesis of mitochondrial proteins is altered in the old animals, and mitochondria isolated from the livers of old rats showed greater susceptibility to inhibition.