Showing papers in "Human Pathology in 1989"

TL;DR: Findings indicate that NASH is, in general, a clinically mild and biologically low-grade condition, but with the potential to progress and evolve into cirrhosis in some patients, although the factors promoting progression are unclear.

TL;DR: The entity "microscopic colitis" shows characteristic histopathology including prominent lymphocytic infiltration of epithelium, and thus, a more appropriate designation isymphocytic colitis, which is readily distinguishable from idiopathic inflammatory bowel disease, acute forms ofcolitis, and normal colorectum.

TL;DR: MHC-I expression on muscle fibers is necessary but not sufficient for TCMC in myopathy; that the biological significance of increased MHC- I expression in DM remains undefined; and that currently available and appropriately controlled immunocytochemical methods show no relationship between increased M HC-Iexpression on muscle fiber and local IFN synthesis by mononuclear cells.

TL;DR: This distinctive form of metaplastic carcinoma with direct transition to a cartilaginous and/or osseous stromal matrix without an intervening spindle cell zone or osteoclastic giant cells is designated as "matrix-producing carcinoma" (MPC).

TL;DR: Findings, in conjunction with histopathologic features, and ultrastructural observations from three cases, support myoepithelium as an integral component of SpCC.

TL;DR: Results show that GCDFP-15 is a specific marker for breast cancer and is superior to ALA in this respect.

TL;DR: Recognition is given to acknowledging the multiple factors and interactive processes responsible for breast epithelial stimulation when considering strategies of intervention for oral contraceptive use and breast cancer risk.

TL;DR: Fundamental principles of flow cytometry with emphasis on DNA measurements and cell cycle analysis in human cells and tissues are summarized and fundamental questions concerning definitions of "diploid" and "aneuploids" tumors have not been satisfactorily settled.

TL;DR: Despite the findings of this interobserver study, dysplasia has been a successful marker in clinical practice and pathologists should ensure that they have access to previous slides from the same patient and adequate clinical information before reporting biopsies as positive for Dysplasia.

TL;DR: The use of an immunohistochemical panel, in addition to routine histology, can confirm the diagnosis of a paraganglioma and can give an indication of the likely prognosis for a patient.

TL;DR: New insights into morphogenesis suggest that the limb body wall malformation complex results from a malfunction in the ectodermal placodes and that it can be considered to be an embryonic dysplasia.

TL;DR: It is hypothesized that intrinsic arterial wall changes (medial disruption) at the plaque-free segment and the resulting altered arterial geometry at the site of dilatation have a significant hemodynamic effect on the vascular conduit and may enhance and sustain the myoproliferative intimal response.

TL;DR: A series of 36 cases of chondromyxoid fibroma (CMF) of bone, a rare benign tumor that may be confused with chondrosarcoma, is presented to aid in correctly identifying and diagnosing these neoplasms.

TL;DR: Some unusual locations were found in chondroblastomas, such as the skull and facial bones and the small tubular bones of the hands and feet, but the biological behavior of these tumors was that of a benign process with only limited local aggressiveness.

TL;DR: It is concluded that numbers of eosinophils and mast cells may play a role in the natural history of rectal cancer but only the latter represents a prognostic parameter independent of Dukes' stage or nodal status.

TL;DR: Findings indicate that B-type LCL is the most common outcome when NP progresses into a lesion of higher malignancy and provide further evidence of a close relationship of NP to the B-cell system.

TL;DR: Judging from the relative survival curves, no significant excess mortality of cancer occurred toward the end of the follow-up period in the PMC group, but nodal status was closely related to the histologic type.

TL;DR: A positive relationship between the mean numbers of AgNOR sites per nucleus and tumor growth fraction, as determined by immunostaining with the monoclonal antibody Ki-67, in 83 malignant breast tumors supports recent suggestions that the NOR count may reflect cell synthetic activity and hence, proliferation.

TL;DR: In situ hybridization with 35S-labeled Epstein-Barr virus probes was applied to paraffin sections of tonsils from seven patients with clinical, serologic, and morphologic evidence of acute infectious mononucleosis, and in no case could EBV be identified in epithelial cells.

TL;DR: Ki-67 staining can be used to characterize the proliferative characteristics of normal colonic mucosa, adenomas, and carcinomas.

TL;DR: The gross and microscopic pathology of alkaptonuric ochronosis is presented from a study of pathologic specimens from six cases in the authors' files and from a review of the literature, and recent electron microscopic discoveries from several affected organs are included in this report.

TL;DR: The role of EBV is discussed in the development of PTLD and the pathogenesis of primary presentation in the allograft, and there was clinical recovery with reduced immunosuppression and acyclovir.

TL;DR: Findings are of practical importance in routine surgical pathology, particularly with respect to the differential diagnosis of gliomas located in the central nervous system and in immunohistochemical studies of peripherally located, poorly differentiated neoplasms.

TL;DR: The morphologic and clinical features of the peritoneal serous papillary serous tumors are distinctive enough to warrant their separation from mesotheliomas.

TL;DR: Aspiration biopsy has caused us to explore how the human eye and brain analyze microscopic images and may even assist in the design of useful artificial intelligence diagnostic systems in the future.

TL;DR: The testes of the AIDS patients showed a significantly lower degree of spermatogenesis, as well as more prominent thickening of the basement membrane and interstitial fibrosis when compared with the controls, which can be ascribed to AIDS and/or homosexuality.

TL;DR: Flow cytometric analysis revealed euploidy in one classic CMN, one cellular CMN and in classic areas of a combined CMN; cellular areas of the latter tumor were aneuploid.