Showing papers in "International Scholarly Research Notices in 2011"
TL;DR: The principles, advantages and disadvantages of immobilization, soil washing and phytoremediation techniques which are frequently listed among the best demonstrated available technologies for cleaning up heavy metal contaminated sites are presented.
Abstract: Scattered literature is harnessed to critically review the possible sources, chemistry, potential biohazards and best available remedial strategies for a number of heavy metals (lead, chromium, arsenic, zinc, cadmium, copper, mercury and nickel) commonly found in contaminated soils. The principles, advantages and disadvantages of immobilization, soil washing and phytoremediation techniques which are frequently listed among the best demonstrated available technologies for cleaning up heavy metal contaminated sites are presented. Remediation of heavy metal contaminated soils is necessary to reduce the associated risks, make the land resource available for agricultural production, enhance food security and scale down land tenure problems arising from changes in the land use pattern.
2,826 citations
TL;DR: This work uses total-variation regularization, which allows for discontinuous solutions in the differentiation process, and accurately differentiates noisy functions, including those which have a discontinuous derivative.
Abstract: We consider the problem of differentiating a function specified by noisy data. Regularizing the differentiation process avoids the noise amplification of finite-difference methods. We use total-variation regularization, which allows for discontinuous solutions. The resulting simple algorithm accurately differentiates noisy functions, including those which have a discontinuous derivative.
395 citations
TL;DR: Predictors of developmental dysplasia of the hip are breech presentation, positive family history, and gender (female), and certain HLA A, B, and D types demonstrate an increase in DDH, both in the northern and southern hemispheres, and swaddling is strongly associated with DDH.
Abstract: The etiology of developmental dysplasia of the hip (DDH) is unknown. There are many insights, however, from epidemiologic/demographic information. A systematic medical literature review regarding DDH was performed. There is a predominance of left-sided (64.0%) and unilateral disease (63.4%). The incidence per 1000 live births ranges from 0.06 in Africans in Africa to 76.1 in Native Americans. There is significant variability in incidence within each racial group by geographic location. The incidence of clinical neonatal hip instability at birth ranges from 0.4 in Africans to 61.7 in Polish Caucasians. Predictors of DDH are breech presentation, positive family history, and gender (female). Children born premature, with low birth weights, or to multifetal pregnancies are somewhat protected from DDH. Certain HLA A, B, and D types demonstrate an increase in DDH. Chromosome 17q21 is strongly associated with DDH. Ligamentous laxity and abnormalities in collagen metabolism, estrogen metabolism, and pregnancy-associated pelvic instability are well-described associations with DDH. Many studies demonstrate an increase of DDH in the winter, both in the northern and southern hemispheres. Swaddling is strongly associated with DDH. Amniocentesis, premature labor, and massive radiation exposure may increase the risk of DDH. Associated conditions are congenital muscular torticollis and congenital foot deformities. The opposite hip is frequently abnormal when using rigorous radiographic assessments. The role of acetabular dysplasia and adult hip osteoarthritis is complex. Archeological studies demonstrate that the epidemiology of DDH may be changing.
234 citations
TL;DR: M Modes of action and potential non-target effects on soil microorganisms should be considered in the selection of fungicide in order to protect the biological functions of soil and optimize the benefits derived from fungicide use in agricultural systems.
Abstract: Fungicides have been used widely in order to control fungal diseases and increase crop production. However, the effects of fungicides on microorganisms other than fungi remain unclear. The modes of action of fungicides were never well classified and presented, making difficult to estimate their possible nontarget effects. In this paper, the action modes and effects of fungicides targeting cell membrane components, protein synthesis, signal transduction, respiration, cell mitosis, and nucleic acid synthesis were classified, and their effects on nontarget microorganisms were reviewed. Modes of action and potential non-target effects on soil microorganisms should be considered in the selection of fungicide in order to protect the biological functions of soil and optimize the benefits derived from fungicide use in agricultural systems.
204 citations
TL;DR: The objective is to provide the orthopaedic surgeons clear and concise information for the correct choice of cement in their clinical practice, focusing on properties, merits, and defects of the antibiotic loaded cement.
Abstract: Infections in orthopaedic surgery are a serious issue. Antibiotic-loaded bone cement was developed for the treatment of infected joint arthroplasties and for prophylaxes in total joint replacement in selected cases. Despite the widespread use of the antibiotic-loaded bone cement in orthopedics, many issues are still unclear or controversial: bacterial adhesion and antibiotic resistance, modification of mechanical properties which follows the addition of the antibiotic, factors influencing the release of the antibiotic from the cement and the role of the surface, the method for mixing the cement and the antibiotic, the choice and the effectiveness of the antibiotic, the combination of two or more antibiotics, and the toxicity. This review discusses all these topics, focusing on properties, merits, and defects of the antibiotic loaded cement. The final objective is to provide the orthopaedic surgeons clear and concise information for the correct choice of cement in their clinical practice.
165 citations
TL;DR: Using locally available natural coagulant treatment of turbid water, suitable, easier, and environment friendly options for water treatment were observed.
Abstract: Turbidity imparts a great problem in water treatment Moringa oleifera, Cicer arietinum, and Dolichos lablab were used as locally available natural coagulants in this study to reduce turbidity of synthetic water The tests were carried out, using artificial turbid water with conventional jar test apparatus Optimum mixing intensity and duration were determined After dosing water-soluble extracts of Moringa oleifera, Cicer arietinum, and Dolichos lablab reduced turbidity to 59, 39, and 111 nephelometric turbidity unit (NTU), respectively, from 100 NTU and 5, 33, and 95, NTU, respectively, after dosing and filtration Natural coagulants worked better with high, turbid, water compare to medium, or low, turbid, water Highest turbidity reduction efficiency (9589%) was found with Cicer arietinum About 89 to 96% total coliform reduction were also found with natural coagulant treatment of turbid water Using locally available natural coagulants, suitable, easier, and environment friendly options for water treatment were observed
150 citations
TL;DR: In this article, the authors addressed the outline of reverse osmosis (RO) and membrane distillation (MD) process for desalination of brackish water and proposed a better alternative to RO.
Abstract: In recent years, the increasing threat to groundwater quality due to human activities has become a matter of great concern. The groundwater quality problems present today are caused by contamination and by overexploitation, or by combination of both, which are faced by many Indian states. Today, reverse osmosis (RO) membranes are the leading technology for desalination of groundwater because of their strong separation capabilities and exhibiting a great potential for treatment of waters worldwide. However, the RO process had some problems due to the formation of polarization films because high pressure operation and by-products which may generate bacteria and fouling. Also, high energy consumption and brine disposal problem is faced in RO process due to the limited recovery of water. These problems may be overcome by other membrane thermal process such as a membrane distillation (MD). This paper addresses the outline of RO and MD process for desalination. RO has developed over the past 40 years and MD is an emerging technology for brackish water desalination and yet is not fully implemented in industry. The MD is the better alternative to RO for desalination theoretically found in the literature.
148 citations
TL;DR: A review of the reliable methods of candidal isolation and identification of isolates from the oral cavity and of infecting strains of Candida.
Abstract: Various techniques are available for the isolation of Candida within the oral cavity. Such methods play an important role in the diagnosis and management of oral candidosis. The growing importance of Candida is in part related to the emergence of HIV infection and the more widespread use of immunosuppressive chemotherapy. Along with the Candida albicans there has been a greater recognition of the importance of the nonalbicans Candida species in oral candidosis. Identification of infecting strains of Candida is important because isolates of Candida species differ widely, both in their ability to cause infection and also in their susceptibility to antifungal agents. Thus this review provides an overview of the reliable methods of candidal isolation and identification of isolates from the oral cavity.
138 citations
TL;DR: Persistence of high-risk HPV infection is the strongest epidemiologic risk factor for CC, however it is not sufficient for development of the disease it cofactors should be present.
Abstract: Cervical cancer (CC) is the third most common cancer in women worldwide; however, CC is a preventable disease, and much effort should be done to prevent it. Persistence of high-risk HPV infection is the strongest epidemiologic risk factor for CC, however it is not sufficient for development of the disease it cofactors should be present. In 2004; IARC listed cervical cancer among those causally related to smoking. Smoking interferes with incidence and prevalence of HPV infection and is associated with cervical intraepithelial neoplasia and invasive CC. Multiple factors seem to intervene on cervical carcinogenesis related with tobacco, especially by direct local carcinogenic effect and local immunosuppression. Smoking addition is also closely related with other confounding factors, like unfavorable psychosocial events, systemic immunity, contraception, and nutrition, which got difficult epidemiologic evaluation of smoking role on cervical carcinogenesis. Smoking habits should be taken in account in clinical practice and in research concerning CC.
126 citations
TL;DR: All stages of the disease pathway from prevention, early identification/diagnosis, and treatment require an understanding of the pathogenesis of liver injury in NAFLD.
Abstract: Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of clinicopathologic conditions ranging from steatosis alone to nonalcoholic steatohepatitis (NASH), with varying risks for progression to cirrhosis and hepatocellular carcinoma. There is mounting evidence that NAFLD not only complicates obesity, but also perpetuates its metabolic consequences. Critical event that leads to progressive liver injury in NAFLD is unknown. Obesity reflects a generalized proinflammatory state with its increased inflammatory markers like C reactive protein, IL-6, IL-8, IL-10, PAI-1, TNF-α, and hepatocyte growth factor. The elevated production of these adipokines is increasingly considered to be important in the development of diseases linked to obesity and the metabolic syndrome. Disordered cytokine production is likely to play a role in the pathogenesis of NAFLD. There is no effective treatment for NAFLD, though weight loss may halt disease progression and revert histological changes, the underlying mechanism remaining elusive. All stages of the disease pathway from prevention, early identification/diagnosis, and treatment require an understanding of the pathogenesis of liver injury in NAFLD.
125 citations
TL;DR: In this article, the effect of the presence of various dopants on the photocatalytic degradation of organic pollutants was examined in the case of nano-doped-TiO2 photocatalyst.
Abstract: This paper aims to review and summarize the recent works on the photocatalytic degradation of various organic pollutants in the presence of nano-doped-TiO2 photocatalysts. In this regard, three main aspects are examined: (a) the presence of various dopants (metal dopants, nonmetal dopants, halogen dopants, metalloid dopants, and codopants) in the formation of nano-doped-TiO2 photocatalysts, (b) the effect of the presence of dopants on the photocatalytic degradation of organic pollutants, and (c) the effects of various operating parameters on the photocatalytic degradation of organic pollutants in the presence of nano-doped-TiO2 photocatalysts. Reports resulted suggest that the formation of a high percentage of the anatase phase, small crystallite size, and high specific surface area of the nano-doped-TiO2 photocatalysts depends on the presence of various dopants in the photocatalysts. The majority of the dopants have the potential to improve the photocatalytic efficiency of nano-doped-TiO2 in the degradation of organic pollutants. The photocatalytic degradation of organic compounds depends on the calcination temperature of the prepared doped TiO2, initial reactant concentration, dosage of doped TiO2, and dopant doping concentration.
TL;DR: While anthracyclines produce CR in half of PTCL patients, this yields reasonable 5-year OS for patients with ALCL but not for those with PTCl-NOS or ETTL, suggesting that novel agents and regimens are needed to improve outcomes for these patients.
Abstract: Anthracycline-based chemotherapy remains standard treatment for peripheral T-cell lymphoma (PTCL) although its benefits have been questioned. We performed systematic literature review and meta-analyses examining the complete response (CR) and overall survival (OS) rates for patients with PTCL. The CR rate for PTCL patients ranged from 35.9% (95% CI 23.4–50.7%) for enteropathy-type T-cell lymphoma (ETTL) to 65.8% (95% CI 54.0–75.9%) for anaplastic large cell lymphoma (ALCL). The 5-year OS was 38.5% (95% CI 35.5–41.6%) for all PTCL patients and ranged from 20.3% (95% CI 12.5–31.2%) for ETTL to 56.5% (95% CI 42.8–69.2%) for ALCL. These data suggest that there is marked heterogeneity across PTCL subtypes in the benefits of anthracycline-based chemotherapy. While anthracyclines produce CR in half of PTCL patients, this yields reasonable 5-year OS for patients with ALCL but not for those with PTCL-NOS or ETTL. Novel agents and regimens are needed to improve outcomes for these patients.
TL;DR: The age-weight, age-height, and height test are useful to differentiate between an idiopathic and atypical SCFE.
Abstract: The etiology of slipped capital femoral epiphysis (SCFE) is unknown with many insights coming from epidemiologic/demographic information. A systematic medical literature review regarding SCFE was performed. The incidence is 0.33/100,000 to 24.58/100,000 children 8 to 15 years of age. The relative racial frequency, relative to Caucasians at 1.0, is 5.6 for Polynesians, 3.9 for Blacks, and 2.5 for Hispanics. The average age is 12.0 years for boys and 11.2 years for girls. The physiologic age when SCFE occurs is less variable than the chronologic age. The average symptom duration is 4 to 5 months. Most children are obese: >50% are >95th percentile weight for age with average BMI is 25–30 kg/m2. The onset of SCFE is in the summer when north of 40°N. Bilaterality ranges from 18 to 50%. In children with bilateral involvement, 50–60% present with simultaneous SCFEs and those who present with a unilateral SCFE and subsequently develop a contralateral SCFE do so within 18 months. The age at presentation is younger for those who present with a unilateral SCFE and later develop a contralateral SCFE. The age-weight, age-height, and height test are useful to differentiate between an idiopathic and atypical SCFE.
TL;DR: Qualitative studies are needed to determine what cancer patients of varied ages, cancer stages, and racial/ethnic backgrounds believe would be an effective intervention to manage their psychosocial needs.
Abstract: Background. Previous integrative literature reviews and meta-analyses have yielded conflicting results regarding the effectiveness of psychosocial interventions for cancer patients. Methods. An integrative review of the literature focused on 19 randomized, controlled trials (2006–2011) was completed to examine the effectiveness of psychosocial interventions for cancer patients. Eligibility criteria: Inclusion criteria were the study was an English language randomized controlled clinical trial. Results. Seven studies involved nurses. Eleven studies resulted in positive outcomes. Overall, study quality was limited. In eight studies the intervention was not adequately described, 7 studies did not contain a hypothesis, 4 did not include clear eligibility criteria, 10 studies did not randomize appropriately, 9 did not list recruitment dates, 11 did not include a power analysis, 14 did not include blinded patients or data collectors, 11 did not use an intent-to-treat analysis, 10 did not clarify reasons for drop outs, and 11 did not discuss treatment fidelity. Conclusions. Future studies should build on previous findings, use comparable outcome measures, and adhere to standards of quality research. Qualitative studies are needed to determine what cancer patients of varied ages, cancer stages, and racial/ethnic backgrounds believe would be an effective intervention to manage their psychosocial needs.
TL;DR: In this article, the authors describe the various aspects of risk, its assessment, and management which are imperative in decision making regarding the safe use of genetically modified organisms (GMOs) and discuss the importance of the risk assessment, management, and precautionary approach in environmental agreements and activism.
Abstract: Commercial potential of biotechnology is immense since the scope of its activity covers the entire spectrum of human life. The most potent biotechnological approach is the transfer of specifically constructed gene assemblies through various techniques. However, this deliberate modification and the resulting entities thereof have become the bone of contention all over the world. Benefits aside, genetically modified organisms (GMOs) have always been considered a threat to environment and human health. In view of this, it has been considered necessary by biosafety regulations of individual countries to test the feasibility of GMOs in contained and controlled environments for any potential risks they may pose. This paper describes the various aspects of risk, its assessment, and management which are imperative in decision making regarding the safe use of GMOs. Efficient efforts are necessary for implementation of regulations. Importance of the risk assessment, management, and precautionary approach in environmental agreements and activism is also discussed.
TL;DR: The critical role that IL-10 plays in gastrointestinal inflammatory diseases and how probiotics could be used in their treatment is demonstrated.
Abstract: Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods and possess a wide range of therapeutic properties. The aim of this paper is to present an overview of the current expanding knowledge of one of the mechanisms by which LAB and other probiotic microorganisms participate in the prevention and treatment of gastrointestinal inflammatory disease through their immune-modulating properties. A special emphasis will be placed on the critical role of the anti-inflammatory cytokine IL-10, and a brief overview of the uses of genetically engineered LAB that produce this important immune response mediator will also be discussed. Thus, this paper will demonstrate the critical role that IL-10 plays in gastrointestinal inflammatory diseases and how probiotics could be used in their treatment.
TL;DR: This narrative review examines the existing literature surrounding the use of exercise and physical therapy in the primary and secondary prevention of stroke and explores the effect of gender, exercise intensities and the duration of observed benefit.
Abstract: The role of physical activity in the prevention of stroke is of great interest due to the high mortality and significant impact of stroke-related morbidity on the individual and on healthcare resources. The use of physical activity as a therapeutic strategy to maximise functional recovery in the rehabilitation of stroke survivors has a growing evidence base. This narrative review examines the existing literature surrounding the use of exercise and physical therapy in the primary and secondary prevention of stroke. It explores the effect of gender, exercise intensities and the duration of observed benefit. It details the most recent evidence for physical activity in improving functional outcome in stroke patients. The review summaries the current guidelines and recommendations for exercise therapy and highlights areas in which further research and investigation would be useful to determine optimal exercise prescription for effective prevention and rehabilitation in stroke.
TL;DR: In this paper, the authors proposed nonpharmacological prophylaxis for post-operative atrial fibrillation (POAF) such as adequate control of postoperative pain, the use of thoracic epidural analgesia, optimization of perioperative oxygen delivery, and modulation of surgery-associated inflammatory response with immunonutrition and antioxidants.
Abstract: Postoperative atrial fibrillation (POAF) is common among surgical patients and associated with a worse outcome. Pathophysiology of POAF is not fully disclosed, and several perioperative factors could be involved. Direct cardiac stimulation from perioperative use of catecholamines or increased sympathetic outflow from volume loss/anaemia/pain may play a role. Metabolic alterations, such as hypo-/hyperglycaemia and electrolyte disturbances, may also contribute to POAF. Moreover, inflammation, both systemic and local, may play a role in its pathogenesis. Strategies to prevent POAF aim at reducing its incidence and ameliorate global outcome of surgical patients. Nonpharmacological prophylaxis includes an adequate control of postoperative pain, the use of thoracic epidural analgesia, optimization of perioperative oxygen delivery, and, possibly, modulation of surgery-associated inflammatory response with immunonutrition and antioxidants. Perioperative potassium and magnesium depletion should be corrected. The impact of those interventions on patients outcome needs to be further investigated.
TL;DR: The spectrum of bacteria naturally associated with maize roots is wide and the magnitude of such diversity will depend on the methods chosen for analysis, the knowledge of this spectrum will facilitate the search of microorganisms capable of exerting antagonism to diverse pathogens or detecting plant growth enhancers.
Abstract: The present study investigated bacterial diversity associated with the roots of maize through the use of culture-dependent and culture-independent methods. Bacterial 16S–23S rDNA internal transcribed spacer sequences (ITS) primers were used to amplify sequences obtained directly from the root matrix by Percoll gradient separation. This assay showed that γ-Proteobacteria within Enterobacter, Erwinia, Klebsiella, Pseudomonas ,a ndStenotrophomonas genera were predominant groups. The culturable component of the bacterial community was also assessed, revealing that the predominant group was Firmicutes, mainly of Bacillus genus, while Achromobacter, Lysinibacillus ,a ndPaenibacillus genera were rarely found in association with the roots. Only two genera within γ-Proteobacteria, Enterobacter and Pseudomonas, were found in the culture collection. Differences in richness and diversity between the rhizospheric and endophytic bacterial communities were also evidenced. The spectrum of bacteria naturally associated with maize roots is wide and the magnitude of such diversity will depend on the methods chosen for analysis. The knowledge of this spectrum will facilitate the search of microorganisms capable of exerting antagonism to diverse pathogens or detecting plant growth enhancers.
TL;DR: Educational status was the best predictor of awareness of birth preparedness, but not a good predictor of intention to attend four antenatal clinic sessions, and parity was a better predictor of knowledge of severe vaginal bleeding as a key danger sign during pregnancy.
Abstract: The aims of this study are to assess the awareness and intention to use maternity services. This was a multicentric study involving 800 women. Educational status was the best predictor of awareness of birth preparedness (𝑃=0.0029), but not a good predictor of intention to attend four antenatal clinic sessions (𝑃=0.449). Parity was a better predictor of knowledge of severe vaginal bleeding as a key danger sign during pregnancy than educational level (𝑃=0.0009 and 𝑃=0.3849, resp.). Plan to identify a means of transport to the place of childbirth was related to greater awareness of birth preparedness (𝜒2=0.3255; 𝑃=0.5683). Parity was a highly significant predictor (𝑃=0.0089) of planning to save money. Planning to save money for childbirth was associated with greater awareness of community financial support system (𝜒2=0.8602; 𝑃=0.3536). Access to skilled birth attendance should be promoted.
TL;DR: Through screening of common bacteria, extracellular biosynthesis of metallic silver nanoparticles by the reduction of aqueous Ag is reported.
Abstract: The development of reliable and eco-friendly organisms of silver nanomaterials is an important aspect of current nanotechnology research and application. Recently, microorganisms have been explored as potential biofactory for synthesis of silver nanoparticles. In this study, through screening of common bacteria, we report extracellular biosynthesis of metallic silver nanoparticles by the reduction of aqueous Ag
TL;DR: It is concluded that measures aimed at alleviating heat stress in domestic chickens must be adopted in order to enhance reproductive and, consequently, efficiency of modern poultry production in the tropics.
Abstract: The paper examines heat stress and its adverse effects as a hindrance to profitable poultry production in the tropics, with emphasis on the Northern Guinea Savannah zone of Nigeria. It elucidates the general negative effects of heat stress on physiological parameters of domestic chickens, and the specific impact of the stress on reproduction in the tropics. The deleterious effects are expressed in poor poultry well-being and reproductive performance. It is concluded that measures aimed at alleviating heat stress in domestic chickens must be adopted in order to enhance reproductive and, consequently, efficiency of modern poultry production in the tropics.
TL;DR: Nitric oxide donors and/or iNOS inhibitors may have therapeutic potential in asthma treatment and can also be used with corticosteroids to counteract airway remodeling.
Abstract: Asthma is a chronic inflammatory airway disease characterized by allergen-induced airway hyperresponsiveness, airway inflammation, and remodeling. Nitric oxide (NO) derived from constitutive and inducible enzymes affects many aspects of asthma physiopathology. Animal in vivo studies have indicated that inhibition of iNOS may play a central role in the modulation of these features, particularly extracellular matrix remodeling. Additionally, increases in iNOS-derived NO, observed in asthmatic patients, may lead to an increase in peroxynitrite and an imbalance of oxidant and antioxidant pathways. In addition, endogenous nitric oxide produced by constitutive enzymes may protect against the remodeling of the lung. Therefore, nitric oxide donors and/or iNOS inhibitors may have therapeutic potential in asthma treatment and can also be used with corticosteroids to counteract airway remodeling. This paper focuses on the pathophysiological role of nitric oxide, mainly derived from inducible isoforms, in the various pathologic mechanisms of allergic asthma and the importance of nitric oxide and/or arginase inhibitors in asthma treatment.
TL;DR: In vitro release data were fitted to various models to ascertain kinetic of drug release and results of the F2 statistics between factorial design batches and theoretical profile were used to select optimized batch.
Abstract: Repaglinide has the half life of 1 hour, and bioavailability in the body is 56% due to first-pass metabolism. The total daily dose of Repaglinide is 16 mg (e.g., 4 mg four times daily depending on meal patterns); hence, it required frequent dosing. Transdermal patch of Repaglinide was prepared to sustain the release and improve bioavailability of drug and patient compliance. Different formulations were prepared by varying the grades of HPMC and concentration of PVP K30 by solvent casting method. The prepared formulations were evaluated for various parameters like thickness, tensile strength, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content, in vitro drug release, in vitro permeation, and drug excipient compatibility. A 32 full factorial design was applied to check the effect of varying the grades of HPMC (𝑋1) and PVP concentration (𝑋2) on the responses, that is, tensile strength, percentage drug released in 1 hr (𝑄1), 9 hr (𝑄9), and diffusion coefficient as a dependent variables. In vitro release data were fitted to various models to ascertain kinetic of drug release. Regression analysis and analysis of variance were performed for dependent variables. The results of the F2 statistics between factorial design batches and theoretical profile were used to select optimized batch. Batch F6 was considered optimum batch which contained HPMC K100 and PVP (1.5%), showed release 92.343% up to 12 hr, and was more similar to the theoretical predicted dissolution profile (𝑓2=69.187).
TL;DR: A 46-year-old male presented with symptoms of appendicitis, diagnosed with adenocarcinoma of the appendix, and refused further surgical intervention to complete hemicolectomy, remaining asymptomatic up to date.
Abstract: Cancers of the appendix are rare. Most of them are found accidentally on appendectomies performed for appendicitis. When reviewed, majority of the tumors were carcinoid, adenoma, and lymphoma. Adenocarcinomas of appendix are only 0.08% of all cancers and the treatment remains controversial. Here we are reporting a 46-year-old male presented with symptoms of appendicitis, diagnosed with adenocarcinoma of the appendix. The patient was treated with appendectomy and refused further surgical intervention to complete hemicolectomy. Up to date, he remains asymptomatic. We performed literature review of the tumors of the appendix. Most of the benign conditions are treated with surgery alone. Lymphomas require CHOP-like chemotherapy and carcinoid syndrome treatment with somatostatin analogues. It is generally recommended that right hemicolectomy is the preferred treatment for adenocarcinoma of appendix. The role of chemotherapy is unclear due to lacking randomized trials but seems to be accepted if there is lymph node involvement or peritoneal seeding.
TL;DR: VCO is efficacious for WC reduction especially in males and it is safe for use in humans and it has no change in the lipid profile.
Abstract: Introduction. This is an open-label pilot study on four weeks of virgin coconut oil (VCO) to investigate its efficacy in weight reduction and its safety of use in 20 obese but healthy Malay volunteers. Methodology. Efficacy was assessed by measuring weight and associated anthropometric parameters and lipid profile one week before and one week after VCO intake. Safety was assessed by comparing organ function tests one week before and one week after intake of VCO. Paired 𝑡 -test was used to analyse any differences in all the measurable variables. Results. Only waist circumference (WC) was significantly reduced with a mean reduction of 2.86 cm or 0.97% from initial measurement ( 𝑃 = . 0 2 ). WC reduction was only seen in males ( 𝑃 . 0 5 ). There was no change in the lipid profile. There was a small reduction in creatinine and alanine transferase levels. Conclusion. VCO is efficacious for WC reduction especially in males and it is safe for use in humans.
TL;DR: Nonpharmacological or mechanical approaches such as inferior vena cava filters, graduated compression stockings, and intermittent pneumatic compression devices in combination with pharmacological interventions or alone may be a good approach to manage VTE.
Abstract: Venous thromboembolism (VTE) is categorised as deep venous thrombosis (DVT) and pulmonary embolism (PE). VTE is associated with high morbidity and causes a huge financial burden on patients, hospitals, and governments. Both acquired and hereditary risks factors contribute to VTE. To diagnose VTE, noninvasive cost-effective diagnostic algorithms including clinical probability assessment and D-dimer measurement may be employed followup by compression ultrasonography for suspected DVT patients and multidetector computed tomography angiography for suspected PE patients. There are pharmacological and mechanical interventions to manage and prevent VTE. The pharmacological approaches mainly target pathways in coagulation cascade nonspecifically: conventional anticoagulants or specifically: new generation of anticoagulants. Excess bleeding is one of the major risk factors for pharmacological interventions. Hence, nonpharmacological or mechanical approaches such as inferior vena cava filters, graduated compression stockings, and intermittent pneumatic compression devices in combination with pharmacological interventions or alone may be a good approach to manage VTE.
TL;DR: In this paper, the authors studied whether immune system-related genes are activated and have prognostic significance in Ewing's sarcoma family of tumors (ESFTs) and identified prognostically significant inflammatory genes (C5, JAK1, and IL8) for ESFT.
Abstract: Background. Unlike in most adult-onset cancers, an association between typical paediatric neoplasms and inflammatory triggers is rare. We studied whether immune system-related genes are activated and have prognostic significance in Ewing's sarcoma family of tumors (ESFTs). Method. Data analysis was performed on gene expression profiles of 44 ESFT patients, 11 ESFT cell lines, and 18 normal skeletal muscle samples. Differential expression of 238 inflammation and 299 macrophage-related genes was analysed by t-test, and survival analysis was performed according to gene expression. Results. Inflammatory genes are activated in ESFT patient samples, as 38 of 238 (16%) inflammatory genes were upregulated (P < 0.001) when compared to cell lines. This inflammatory gene activation was characterized by significant enrichment of macrophage-related gene expression with 58 of 299 (19%) of genes upregulated (P < 0.001). High expression of complement component 5 (C5) correlated with better event-free (P = 0.01) and overall survival (P = 0.004) in a dose-dependent manner. C5 and its receptor C5aR1 expression was verified at protein level by immunohistochemistry on an independent ESFT tumour tissue microarray. Conclusion. Immune system-related gene activation is observed in ESFT patient samples, and prognostically significant inflammatory genes (C5, JAK1, and IL8) for ESFT were identified.
TL;DR: Clinicians must maintain a high index of suspicion for fracture when evaluating this group to avoid morbidity and mortality and begin immobilization in the patient's preinjury alignment to prevent iatrogenic neurologic injury.
Abstract: Ankylosing Spondylitis (AS) is a multifactorial and polygenic rheumatic condition without a well-understood pathophysiology (Braun and Sieper (2007)). It results in chronic pain, deformity, and fracture of the axial skeleton. AS alters the biomechanical properties of the spine through a chronic inflammatory process, yielding a brittle, minimally compliant spinal column. Consequently, this patient population is highly susceptible to unstable spine fractures and associated neurologic devastation even with minimal trauma. Delay in diagnosis is not uncommon, resulting in inappropriate immobilization and treatment. Clinicians must maintain a high index of suspicion for fracture when evaluating this group to avoid morbidity and mortality. Advanced imaging studies in the form of multidetector CT and/or MRI should be employed to confirm the diagnosis. Initial immobilization in the patient's preinjury alignment is mandatory to prevent iatrogenic neurologic injury. Both nonoperative and operative treatments can be employed depending on the patient's age, comorbidities, and fracture stability. Operative techniques must be individually tailored for this patient population. A multidisciplinary team approach is best with preoperative nutritional assessment and pulmonary evaluation.
TL;DR: Close attention must be paid to the geographic expansion and/or diversification of TTX-bearing organisms, and to the sudden occurrence of other forms ofTTX poisoning due to their ingestion.
Abstract: Marine pufferfish generally contain a large amount of tetrodotoxin (TTX) in their skin and viscera, and have caused many incidences of food poisoning, especially in Japan. Edible species and body tissues of pufferfish, as well as their allowable fishing areas, are therefore clearly stipulated in Japan, but still 2 to 3 people die every year due to pufferfish poisoning. TTX is originally produced by marine bacteria, and pufferfish are intoxicated through the food chain that starts with the bacteria. Pufferfish become nontoxic when fed TTX-free diets in a closed environment in which there is no possible invasion of TTX-bearing organisms. On the other hand, TTX poisoning due to marine snails has recently spread through Japan, China, Taiwan, and Europe. In addition, TTX poisoning of dogs due to the ingestion of sea slugs was recently reported in New Zealand. TTX in these gastropods also seems to be exogenous; carnivorous large snails are intoxicated by eating toxic starfish, and necrophagous small-to-medium snails, the viscera of dead pufferfish after spawning. Close attention must be paid to the geographic expansion and/or diversification of TTX-bearing organisms, and to the sudden occurrence of other forms of TTX poisoning due to their ingestion.