Showing papers in "Journal of Drug Delivery Science and Technology in 2006"

TL;DR: The present review article mainly focuses on strategy and molecular design of thermoresponsive polymeric micelles and discusses their potential for an intelligent targeted drug carrier system with some examples containing anti-cancer drugs.

TL;DR: The results highlight the critical role of the CS coating in enhancing the transport of the associated peptide and, hence, the potential utility of CS nanocapsules for nasal peptide delivery.

TL;DR: This review focuses on biological and chemical characteristics of stimuli-sensitive release systems for protein and peptide delivery and identifies important guidelines as well as unsolved problems in this field.

TL;DR: Results indicate that the blood glucose levels of diabetics can be effectively controlled by oral ILP administration, and it is anticipated that the complexation hydrogels will be used for clinical development of oral insulin delivery system.

TL;DR: The procedure of the incorporation of pancreatic proteases or ovalbumin into microparticles by layer-by-layer adsorption of oppositely charged polyelectrolytes on a proteinaceous core is described and they seem to be a promising vehicle for oral protein delivery.

TL;DR: Salt-induced phase separations in solutions of water soluble non-stoichiometric polyelectrolyte complexes (WPECs) formed by poly(N-ethyl-4-vinylpyridinium) polycation with different polyanions – sodium poly(methacrylate), sodiumpoly(styrenesulfonate), and DNA – have been explored.

TL;DR: In this article, a pH-sensitive hydrogel was prepared by UV irradiation technique, where starting polymer was obtained from α,β-poly (N-2-hydroxyethyl)-DL-aspartamide (PHEA) partially derivatized with glycidyl methacrylate (PHG).

TL;DR: In this article, the authors describe the preparation, characterization and properties of niosomal and liposomal carriers for the topical application of 8-metho.xypsoraten (8-MOP).

TL;DR: Results provide useful insights into the suitability of this system for oral immunization with microencapsulated antigens, and the microencapulation seems to improve the VA uptake by Peyer's patches vs. free particulate.

TL;DR: In this paper, the poloxamer macromolecules per se have interesting thermo-associating properties in aqueous solutions but they can also be integrated as sub-units in the design of more complex molecular architectures such as grafted poloxamers.

TL;DR: It was established that collagenase D may be used for treatment of keloids and hypertrophic scars and Liniment Morikrol containing collagenase PC was effectively applied for scar treatment and in other cases where skin may regenerate.

TL;DR: In principle, styling the nanotube (by adding functional groups or ligands) may achieve the selectivity of the nanosyringe’s landing area on the cellular membrane and implement it in drug delivery system construction.

TL;DR: It is suggested that microemulsions containing AZA-Na could be used to optimize drug targeting in acne treatment because of its ability to deliver the drug through the skin.

TL;DR: An overview of the different applications of pH-sensitive microparticles for oral administration emphasizes their versatility and underlines that they may be an interesting tool in order to open new therapeutic pathways for a large diversity of diseases.

TL;DR: In this paper, the authors compared results obtained from a theoretical model with those acquired from the experimental characterization of different Orami.x NS10/cliolesterol mixtures and concluded that the mathematical model is a useful and reproducible tool capable of predicting the type of aggregation structures given by the alkylpolyglucoside in water.

TL;DR: In this paper, the lower critical solution temperature (LCST) of poly(N-isopropylacrylamide)-g-Guar gum (PNIAAm-g-GG) was shown to be approximately 37.5°C.

TL;DR: Gellan gum was evaluated as a binding agent in lactose-based tablets containing metronidazole or paracetamol as mentioned in this paper, and the binding properties of the gum were compared with acacia and gelatin.

TL;DR: In this paper, an attempt was made to enhance the dissolution rate of indomethacin using various molecular weights of polyethylene glycol (PEG2000, 6000 and 20000) by a cogrinding technique.

TL;DR: In this paper, a new technique is introduced to measure a resistance to compression index (RCI) for granulations and direct compression powder blends with increasing concentration (C) of lubricants as parameter of their efficacy.

TL;DR: In this paper, the core-shell structure of Dex-PCL nanoparticles was characterized by Pseudomonas lipase and showed that most of the drug was located in the core of the Dex-PCL nanoparticles.

TL;DR: In this paper, a photochemical cross-linking reaction of metacrylated dextran (DEX-MA) functionalized with acidic residues through reaction with anhydrides of different nature (succinic, glutaric and phthalic respectively) was characterized by FT-IR spectra and swelling measurements.

TL;DR: A pH/temperature sensitive polymer of poly(aspartic acid) grafted with poly(propylene glycol) (PA-g-PPG) was prepared.

TL;DR: Mucosal IgA titers suggest polysaccharide-capped niosomal systems could be a potential oral vaccine delivery system and could produce better humoral response as compared to their plain counterpart.

TL;DR: These studies showed that NIF permeation rate across the different in vitro models evaluated can be significantly enhanced (x 6-fold) by formulation of NIF as nanoparticles.

TL;DR: The regulation of the gastric acidity has no statistically significant effect on the gastrointestinal transit of liquids and can be useful when predicting the in vivo performance of drugs in humans from the data of bioavailability studies with dogs whose gastric pH was regulated.

TL;DR: Ability of the copolymers to favor penetration of the oligonucleotide into immortalized NIH/3T3 mouse fibroblasts transfected with the EWS-Fli1 cDNA under the control of the LTR retroviral promoter was investigated.

TL;DR: In vivo studies showed higher drug concentrations in skin from the liposome-gel formulation, which showed an encouraging perspective on the use of liposomal systems for improving topical bioavailability and local pharmacotherapy for HA.

TL;DR: In vitro and in vivo evaluations of floating capability were performed and the pharmacokinetic parameters were investigated, leading to the observation that the mean amount of riboflavin excreted in the urine seemed to increase when FMT were administered after a meal, but did not increase when NFMT were administer.

TL;DR: In this article, the authors investigated the release characteristics of acrylic terpolymer MCs containing fluorescein isothiocyanate-labeled dextran (FITC-Dex) of different average molecular weights or small molecular drugs of different solubilities.

TL;DR: In this article, the influence of the inclusion of retinyl palmitate (RetP) in unilamellar vesicles on light-induced degradation was evaluated.