Showing papers in "Journal of Neuroimmunology in 1982"

TL;DR: It is hypothesized that the ascending progression of clinical signs of EAE in rodents can be explained on an anatomical basis by progressive disturbance of the nodes of Ranvier in nerve root myelinated fibers.

TL;DR: Observations suggest that microtubules are involved in the initial establishment of cytoplasmic asymmetry and process development, and glial filaments may play a role in maintaining and stabilizing the overall geometry of the mature astrocyte.

TL;DR: The findings indicate that timing of immunosuppression is critical in determining the extent of TV demyelination, and the "bystander effect' may be important in early demyELination, but late demyElination may be due to other causes, such as oligodendrocyte lytic infection.

TL;DR: In frozen sections of thymus from 9 out of 12 myasthenia gravis patients, the medulla contained follicles of B lymphocytes with germinal centres showing the same immunofluorescence staining pattern as is seen normally in reactive lymphoid tissues.

TL;DR: The data indicate that the GSF production and secretion mechanism is much like that described for other lymphokines, as determined by resistence to treatment with mitomycin C.

TL;DR: The ability of alpha FP to suppress an experimental autoimmune disease, as presented in this model of EAE, indicates that clinical remissions of human autoimmune disease during pregnancy may be attributed to the effect of this natural substance.

TL;DR: Cell-type-specific antigenic markers which allow the unambiguous identification of the major neural cell types in dissociated cell cultures of central nervous system and peripheral nervous system tissues from a variety of animal species have recently been established.

TL;DR: Results would support the conclusion that macrophages function during the effector stage in the clinical and pathological expression of EAN in the Lewis rat.

TL;DR: In this article, the authors proposed that the pathogenesis of demyelination in multiple sclerosis (MS) might lie in the cooperative effect of a T cell response against one myelin antigen (e.g. myelin basic protein - MBP) and a B-cell response against a second myelin component which may act as a hapten or a carrier for the primary antigen.

TL;DR: Findings provide further evidence for the existence of GSF as a new lymphokine, distinct from LIF, MIF, MF and LAF.

TL;DR: The data presented here establish the unique nature of the detected antigenic specificities as compared to previously described oncofetal and onconeural antigens, and define two immune reagents which are operationally specific for tumors of neuroectodermal origin within the adult central nervous system.

TL;DR: For example, this paper found that the probability of isolation from any particular region of the central nervous system (CNS) seems to be a function of the distance of that area from the root-entry zone of the trigeminal nerve.

TL;DR: A comparison of photometric signals allows the direct detection of specific antibodies which have been secreted by activated tissue B lymphocytes into the CSF compartment during the humoral immune phase of herpes simplex encephalitis.

TL;DR: Scrapie incubation periods were identical in affected males and unaffected females, indicating that B cell maturation does not influence the course of scrapie, and highly enriched preparations of the scrapie agent were used to raise antibodies in rabbits using an extensive immunization protocol.

TL;DR: It is suggested that myelin sheaths are the primary targets in EAE-induced demyelination and oligodendroglia appear to be relatively unaffected and are available to remyelinate axons.

TL;DR: A reference range has been established after assaying sera from 200 healthy individuals, 314 patients with diseases often considered in the differential diagnosis of myasthenia gravis or found in association with MG, and 72 patients with active adult onset MG.

TL;DR: An alpha-bungarotoxin-binding protein was partially purified from rat brain and was shown to behave as a single radiolabelled protein that is distinct from the similarly complexed nAChR from Torpedo marmorata.

TL;DR: The results suggest that T-lymphocytes are involved in the pathogenesis of both MS and SSPE.

TL;DR: Adult and developing rat cerebella were stained immunocytochemically with six neuron-specific monoclonal antibodies obtained from spleen cells of BALB/c mice immunized with hypothalamus, and differences in staining probably reflect developmental regulation of the antigens (neurotypes).

TL;DR: The fact that CSF IgG bands were present in some patients before the appearance of HSV antibodies, and also persisted longer, suggests that the IgG response is not restricted to HSV-specific antigenic determinants.

TL;DR: It was concluded that the subarachnoid space is a highly efficient site for the induction of systemic antibody production, in particular to low amounts of T-dependent antigens.

TL;DR: The mixed haemagglutination technique was used to demonstrate antibodies to peripheral nerve tissue (PNS) in sera from patients with acute Guillain-Barré syndrome, and antibodies were detected in 60% of the patients with severe GBS, and in 30% of those with a mild GBS.

TL;DR: The difference in light chain predominance of MS and SSPE CSF may reflect differences in the antigenic target, or the age of patient at the time when band-synthesizing clones are triggered.

TL;DR: It is shown that typical cases of Guillain-Barré syndrome may, however, appear weeks to months later and evidence is suggested in favour of a humoral, rather than a cell-mediated, aetiology for GBS.

TL;DR: Findings suggest that the B cells do not mediate suppression on EAE via production of blocking antibody, but may function directly, perhaps by triggering T cells to become suppressor cells.

TL;DR: It is found that the divalent F(ab')2 and monovalent Fab' fragments derived from antiganglioside IgG molecules are able to induce epileptiform seizures, and this result supports the view that the binding of antibodies to gangliosid receptors in the synaptic membrane is sufficient in itself to initiate changes in membrane processes which lead to epileptic spiking.

TL;DR: Differences in IgG patterns of sera, CSF, pooled brain eluates, and plaques or regional eluates from single cases of MS suggest: either that all MS oligoclonal IgG is "nonsense' antibody in terms of disease pathogenesis, or (b) much of the MS oligocentrifying antibody is " nonsense' antibodies, present as part of a specific oligOClonal immune reaction.

TL;DR: The ultrastructure of dissociated rat sciatic nerve Schwann cells and fibroblasts has been examined and correlated at the morphologic and immunocytochemical levels and provides a basis for future studies with this system to which neuronal elements may be added in an attempt to initiate myelinative events.

TL;DR: A new sensitive method enables to study theCSF proteins: unconcentrated CSF proteins after agar gel electrophoresis are stained with silver reagents and allows to follow the evolution of the inflammatory reaction in chronic relapsing EAE as well as in the acute form of EAE.

TL;DR: The production of highly specific antiserum toGM4 and the feasibility of detecting antibodies to glycolipid antigens by a convenient solid-phase RIA should be useful to further study the biological and immunological roles of GM4 and other Glycolipids in the central nervous system.