Showing papers in "Journal of Neuroimmunology in 2021"

TL;DR: This Review discusses the possible neuroimmunological mechanisms underlying the nervous system and skeletal muscle involvement, and viral triggered neuroIMmunological conditions associated with SARS-CoV-2, as well as therapeutic approaches that have been considered for these specific complications worldwide.

TL;DR: In this paper, a case of longitudinally extensive transverse myelitis (LETM) was reported following vaccination against Covid-19 with AZD1222, AstraZeneca.

TL;DR: In this article, the authors determined SARS-COV-2 IgG response up to 6 months following PfizerBNT162b2 vaccination in 414 multiple sclerosis (MS) patients and 89 healthy subjects.

TL;DR: In this paper, the safety and efficacy of COVID-19 vaccines were evaluated for multiple sclerosis patients and a few incidences of central demyelination were reported, but their benefits likely outweigh their risks if alternatives are unavailable.

TL;DR: In this article, the authors reviewed the literature describing SARS-CoV-2-induced neurological manifestations and provided a comprehensive discussion of proposed mechanisms underlying the neurological pathophysiology.

TL;DR: In this paper, the authors summarized the pathogenic role of exosomal miRNAs in several autoimmune diseases, including myasthenia gravis (MG), psoriasis, inflammatory bowel disease (IBD), type 1 diabetes (T1D), multiple sclerosis (MS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren's Syndrome (SS), systemic sclerosis (SSc), vitiligo, and autoimmune thyroid diseases (AITD).

TL;DR: This is the first reported case of transverse myelitis and dysautonomia in a patient with SARS-CoV-2 infection, who responded to intravenous methyl prednisone and bromocriptine.

TL;DR: In this article, the authors describe two patients who developed sensory Guillain-Barre syndrome (GBS) shortly after the first dose of the ChAdOx1 vaccine.

TL;DR: In this article, the first case of hyperacute reversible encephalopathy following COVID-19 vaccination was described, mainly characterized by agitation and confusion, rapidly responsive to high dosage steroid therapy and complete remission within 3 days from onset.

TL;DR: A novel case of a previously healthy man who presented with a clinical picture of bouts of vomiting and hiccoughs (area postrema syndrome), which rapidly evolved to acute LETM, all following SARS-CoV-2 infection, is reported.

TL;DR: This article reported three cases of Guillain-Barre syndrome and one case of chronic inflammatory demyelinating polyneuropathy (CIDP), presenting to a Tasmanian hospital, and reviewed 15 other reported cases and discuss likely immunopathology.

TL;DR: In this paper, the authors provide updated recommendations on multiple sclerosis management during the COVID-19 crisis and the post-pandemic period applicable to neurology services around the world.

TL;DR: In this paper, a systematic review aimed to determine demographic characteristics, clinical features, lab evaluation, management and complications of the studies focusing on Guillain-Barre syndrome (GBS) as a sequele of novel coronavirus (COVID-19) infection.

TL;DR: In this paper, the role of other inflammasomes in the pathology of Parkinson's disease (PD) remains unclear, however, the NLRP3 inhibitor MCC950 exerts neuroprotective effects in several neurological diseases and may be a novel promising therapeutic approach in treating MPTP-induced PD.

TL;DR: NEAT1 affects AQP4 signaling pathway to alleviate the spinal cord injury-induced NP via promoting miR-128-3p expression.

TL;DR: The inhibition of miR-130a-3p expression up-regulates the IGF-1/IGF-1R signaling pathway, thus reducing neuropathic pain caused by spinal cord injury.

TL;DR: In this article, the colocalization of the SARS-CoV-2 nucleocapsid within neurons, astrocytes, oligodendrocyte and microglia in three deceased COVID-19 cases, of between 78 and 85 years of age at death, was reported.

TL;DR: In this paper, the authors examined the systemic effects of Traumatic brain injury in detail and identified the mechanisms of injury and complications of TBI, and open a window for promising treatment in TBI complications.

TL;DR: In this article, a 44-year-old previously healthy woman developed acute myelitis in close temporal relationship with ChAdOx1 nCoV-19 vaccine first-dose administration.

TL;DR: In this paper, the authors provided a perspective on the function of the JAK/STAT signaling pathway in PD progression and gathered data that describe the rationale evidence on the potential application of Jakinibs to improve neuroinflammation in PD.

TL;DR: In this paper, the authors report the case of a patient with symptoms of myelopathy following acute SARS-CoV-2 infection, and further investigation was unremarkable with the exception of positivity for MOG-IgG in serum.

TL;DR: In this paper, the authors reported a case of HHV6 myelitis with parainfectious MOG-IgG in the setting of COVID-19-induced lymphopenia and hypogammaglobulinemia.

TL;DR: In this paper, the authors showed that MAT treatment alleviated disease severity of ongoing EAE, reduced inflammatory infiltration and demyelination, and reduced the production of inflammatory factors including TNF-α, IL-6, and IL-1β in the CNS.

TL;DR: In this article, a review of the host-parasite association of viruses with MS is presented, where the authors discuss the most popular mode of virus mediated immune system manipulation is molecular mimicry.

TL;DR: In this paper, a novel antigen-specific immunotherapy neutralizing the anti-MAG antibodies with a carbohydrate-based ligand mimicking the natural HNK-1 glycoepitope has been described.

TL;DR: In this article, the thyroid receptor-beta selective sobetirome (Sob) and its CNS-targeted prodrug, Sob-AM2, could prevent myelin and axonal degeneration in experimental autoimmune encephalomyelitis (EAE).

TL;DR: In this paper, a case of new-onset refractory status epilepticus (NORSE) after receiving the first dose of the ChAdOx1 nCoV-19 vaccine was reported.

TL;DR: In this article, the authors discuss the different microelements of the gut microbiota and its connection with the host immune system and how change in immune-microbial signatures correlates with the stroke incidence and post-injury neurological sequelae.

TL;DR: In this article, the authors examined the possible link between gut microbiota composition and multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), and found that patients with MS suffer from dysbiosis.

TL;DR: In this paper, a 40-year-old woman developed cervical myelitis after receiving the COVID-19 vaccine and was considered to be the initial clinical manifestation of MS.