Showing papers in "Journal of Surgical Research in 1993"

TL;DR: The synthesis of type I and III collagens in cultured skin fibroblasts from normal skin, normal scar, hypertrophic scar, and keloids was examined and suggested that at least two distinct mechanisms, one pretranscriptional and one post-transcriptional, regulate type I collagen synthesis.

TL;DR: The role of hypoxia in the release from a human monocyte cell line (THP-1) of tumor necrosis factor-alpha and its soluble membrane receptors (TNF alpha R) in-vitro is investigated in this study.

TL;DR: Preliminary immunofluorescent studies of AAA localized MMP-1 to cells present in the adventitia of AAA will help to resolve disagreement in the recent literature regarding the presence of collagenolytic activity in AAA disease.

TL;DR: Findings in this study mean that the process can be controlled and that the cortical effects will be predictable and reproducible, and should be considered a preliminary test concerning the effects of high energy shock wave on bone.

TL;DR: It is concluded that the Law of Laplace is inaccurate in predicting the complicated stress distributions that exist in aneurysm walls, and that more sophisticated tools will be needed to understand this complex phenomenon.

TL;DR: It is concluded that the activation of pp60c-src between primary tumors and metastases is specific to colon metastases, and although pp60C-src activity is significantly increased in colorectal metastase, site-specific differences in the magnitude of activity are evident.

TL;DR: U74389F normalized MDA, indicating effective inhibition of LP; however, similar epithelial sloughing and edema and hemorrhage in the lamina propria were seen in treated and untreated rats, which implicate MDA-independent or possibly LP-independent pathways in intestinal morphologic damage occurring with I/R.

TL;DR: The amino acid homology comparison of the nine somatostatin analogues revealed that individual differences in their abilities to inhibit angiogenesis may be structurally dependent.

TL;DR: Experiments reported here tested the hypothesis that ornithine accumulating in the extracellular space of wounds serves as a precursor for proline contained in fibroblast secretory proteins and demonstrated that little Ornithine is directly incorporated as protein-bound proline by wound-derived fibroblasts in culture.

TL;DR: It is found that statistically significant elevations in D(-)-lactate concentrations as early as t = 5 min are found in the strangulation obstruction model and SMA ligation model compared to unoperated controls.

TL;DR: XO plays a proximal role in the pathogenesis of remote organ injury following splanchnic hypoperfusion after gut ischemia/reperfusion by producing lung injury by a process that requires PMNs.

TL;DR: Tissue coating with polymer solutions prior to cecal abrasion significantly reduced the formation of post-operative adhesions, and both CMC and gamma-PVP solutions warrant further investigation as tissue precoatings to inhibit surgical adhesion formation.

TL;DR: The effects of high (ballistic) rates of loading in order to determine the contributions to strength made by both the degree of collagen crosslinking and the collagen-matrix interaction are examined.

TL;DR: It is concluded that spinal cord epidural cooling has a highly protective effect against ischemic spinal cord damage under experimental conditions of high thoracic aorta crossclamping in dogs.

TL;DR: The case where traction is prescribed to increase as fibroblasts approach the wound center is shown to obey the commonly observed exponential rate contraction law and to be largely consistent with the findings of McGrath and Simon concerning the independence of the contraction rate constant and final extent of contraction from initial wound size and geometry.

TL;DR: The results show that NO.

TL;DR: This is the first study of its kind to show no effect of hyaluronic acid on the functional strength of tendon after healing in vitro, and the following biomechanical parameters were determined: apparent maximum stress, apparent strain at apparentmaximum stress, normalized energy absorption, and tangent modulus before failure.

TL;DR: It is concluded that fibrin sealing of control anastomoses inhibits wound healing and incomplete anastsomoses are temporarily protected by fibrIn glue sealing.

TL;DR: This study studied changes in NADH fluorescence in rat hepatocyte suspensions and in isolated-buffer-perfused rat livers during hypoxia (pO2 < 50 mm Hg) for periods as long as 180 min.

TL;DR: Data indicate that local (intrinsic) intestinal IL- 1α has a role in sepsis-induced intestinal changes and is markedly correlated with intestinal mucus secretion in response to LPS, and the specific blockage ofIL-1 by the IL-1 receptor antagonist attenuated this response.

TL;DR: The primary objective of this study was to compare the effectiveness of expanded polytetrafluoroethylene (e-PTFE) and polypropylene (PPM) in a rabbit abdominal wall defect model using a double-layer repair technique.

TL;DR: Data from in vitro and animal studies suggest that this agent may have clinical uses in immunocompromised patients who are at increased risk for infectious complications, but the potential for adverse reactions exists when interferon-γ is administered to an immunologically competent host.

TL;DR: This present study examined the contribution of oxygen-derived free radicals to cardiac dysfunction after intestinal ischemia-reperfusion in a rat model of superior mesenteric artery (SMA) occlusion and ligation of collateral arcades from the right colic and jejunal arteries.

TL;DR: It is found that intravascular stents can restore true lumen flow and obliterate the false lumen in experimental dissections; however, stenting limited to the proximal dissection does not prevent formation of a chronic residual patentfalse lumen.

TL;DR: It is concluded that this model of hepatic ischemia/reperfusion results in temporally distinct systemic elevations in IL-6 and TNF; however, the induction of IL- 6 and the associated changes in serum macroglobulin concentration are independent of TNF.

TL;DR: Tenascin immunohistochemical staining was investigated in 82 patients with primary invasive breast carcinoma followed for at least 5 years after surgery, but no definite correlation was found between tenascin positivity and clinical stage, lymph node metastasis, or estrogen receptor status.

TL;DR: The results suggest that endothelins contribute to intestinal hypoperfusion and arteriolar vasoconstriction during bacteremia.

TL;DR: To assess the time course for the prevention of adhesion formation by recombinant tissue plasminogen activator (rt-PA), infusions of rt-PA were administered to rabbits every 12 hr for a total of 1, 2, 4, or 8 days.

TL;DR: As demonstrated in this experimental model, hypertension does indeed increase the rate of growth of abdominal aortic aneurysms and both groups showed elastic lamellar disruption and inflammatory cell infiltration within the wall of the aorta.

TL;DR: HC appears to induce intrinsic changes in smooth muscle cells which are linked to a greater proliferative and abnormal vasomotor capability and applications of vigorous anti-HC regimens perioperatively may be beneficial in maintaining patency over the longer term.