Showing papers in "Journal of the Neurological Sciences in 1985"

TL;DR: The frequency of senile plaques and neurofibrillary tangles and the number of pyramidal neurones and the volume of their nucleolus were measured in temporal cortex and hippocampus of 32 patients with Alzheimer's disease and found to correlate inversely with patient age.

TL;DR: Eleven neuropsychologically normal Parkinsonian patients were studied with [18F]6-fluoro-L-dopa and positron tomography and dopaminergic activity was reduced in the putamen on the side opposite to the major motor signs.

TL;DR: Using EMG equipment with time locked recording and standard averaging facilities the authors were able to record a previously poorly defined skin potential, termed by us the peripheral autonomic surface potential (PASP), which was recorded from the palmar surface of the hand and the plantarsurface of the foot in 30 normal subjects.

TL;DR: The extent of Schwann cell remyelination was influenced by the mode of entry of the cells into the lesion and by the architecture of theLesion, and the presence or absence of stable extracellular matrix is believed to be the prime factor which influenced Schwanncell remyELination.

TL;DR: It is concluded that infusions with FFP, of which the IgG fraction is the effective part, may induce a rapid and clinically important improvement in patients with CIP.

TL;DR: The level of pyruvate dehydrogenase significantly decreased and the level of gamma-glutamyl transpeptidase significantly increased with increasing duration of illness, possibly due to a progressive loss of neurons and increase in the density of glia in Huntington's disease caudate nucleus.

TL;DR: The finding of a fibrinous inflammatory exudate in the acute lesion is a new observation in multiple sclerosis and the observation of an inflammatory infiltrate confined to the vein wall has not been previously recorded in the disease.

TL;DR: It is reported that PHFs may be induced in cultured, fetal human spinal cord lesions by factors other than extracts from brain affected by SDAT, and these induced PHFs are composed of intermediate filaments morphologically identical to neurofilaments.

TL;DR: There were only small differences in the enzymic activities between the two groups indicating that deficiencies of these enzymes are not a very likely cause of brain degeneration in dementias of Alzheimer type.

TL;DR: The findings indicate that the NEB are predominantly innervated by sensory nerve fibers, derived from cell bodies in the nodose ganglion of the vagus nerve, which corroborates the hypothesis that NEB represent intrapulmonary neuroreceptors.

TL;DR: The increased CSF/serum ratios for IgG and albumin and also the higher CSF albumin in patients with AD suggest an increased blood-brain barrier permeability in this disease.

TL;DR: Following spinal cord injury in rats there was a time-dependent change of vascular permeability as reflected by extravasation of 125I-labelled serum albumin suggesting that cord exposure to plasma calcium as a consequence of vascular injury may contribute to the progressive post-traumatic cord necrosis.

TL;DR: The hypothesis that AVP neurons in the SON and PVN are activated in old age is supported after a strong correlation was found between nucleolar size and cell size, both in AVP and OXT neurons.

TL;DR: It is suggested that PLP is encephalitogenic and produces demyelination in the central nervous system without contamination by MBP or GC in Hartley guinea pigs.

TL;DR: The results indicate that brain myelination is affected in obese mutant mice.

TL;DR: In this paper, specific antibody activities (antibody per weight unit IgG) of serum and CSF against a broad variety of viruses were compared in multiple sclerosis and certain inflammatory diseases of the central nervous system, e.g. neurosyphilis, as well as herpes simplex and zoster encephalitis.

TL;DR: It is argued that the disordered axial movements are not the result of an akinetic mechanism but share the criteria applied to apraxic phenomena and the term axial apraxia is proposed.

TL;DR: A 15-year-old girl presented with recurrent encephalopathic episodes, epilepsy, myopathy and chronic lactic acidosis and it is possible that the mitochondrial defect present in skeletal muscle is also being expressed in the brain.

TL;DR: Measurements of plasma glucose concentrations did not suggest that the axonal degeneration could be related to hypoglycaemia, and the number of degenerating axons was very small in the control and untreated diabetic animals but was significantly increased in the insulin-treated group.

TL;DR: Clinical localization of the hemispheric lesion showed no consistent correlation with the type of blink reflex abnormalities and the presence of crossed facilitation to this reflex from wide areas of the cortex but most prominently from the sensory representation of the face is suggested.

TL;DR: The observed morphological changes usually attributed to a primary myopathic process may instead be the manifestations of impaired and incomplete regeneration occurring after cycles of degeneration-regeneration.

TL;DR: Longer periods of ischemia are required to produce nerve damage than suggested by previous tourniquet compression experiments and necrosis is necessary to produce necrosis in the posterior than anterior and lateral compartment muscles of the leg.

TL;DR: Clear-cut signs of BBB damage have been shown only in the group of patients affected by MID, whilst none of the two groups of patients displayed signs of immunological activation, expressed by an increase in IgG index, nor abnormally low CSF/serum ratios for IgG, previously suggested as expressive of a "consumption" of IgG by the brain parenchyma.

TL;DR: It is possible that deficiency of cytochrome oxidase may arise as an epiphenomenon in degenerating mitochondria rather than a primary deficiency.

TL;DR: The correlation of cerebrospinal fluid/serum concentration quotients was used as a method for identification of amino acids which are transported by a common carrier system across the blood-CSF barrier and proline and hydroxyproline have a smaller biological variation in CSF than in serum.

TL;DR: A generalized abnormal distribution of these metals may play a role in the pathogenesis of this disorder.

TL;DR: Serial CSF analysis in patients with acute CNS lesions, suggest that CSF SLI may be a neurochemical marker of acute pathology, as the initially elevated levels fell to or below normal with resolution of the pathologic process.

TL;DR: These complex relationships between the types of SEP abnormalities and thalamic lesions are compatible with the presence of multiple, at least partially independent, thAlamic generators and thalamocortical projection systems mediating regionally specific SEP components.

TL;DR: In this article, the authors investigated the possibility of local antigen presentation within the central nervous system (CNS) in multiple sclerosis (MS) and found that Ia+ endothelial cells and astrocytes were mainly found at the edge of active chronic MS lesions.

TL;DR: High prevalence of brainstem involvement and cerebellar dysfunction and infrequent occurrence of the severe optic-spinal form and sphincter disturbance indicates that the present group of patients resembles Western pattern of MS as opposed to Asian MS.