IL-10, IL-6, and TNF-α: Central factors in the altered cytokine network of uremia—The good, the bad, and the ugly
Peter Stenvinkel,Markus Ketteler,Richard J. Johnson,Bengt Lindholm,Roberto Pecoits-Filho,Miguel C. Riella,Olof Heimbürger,Tommy Cederholm,Matthias Girndt +8 more
TLDR
Given the strong association between proinflammatory cytokines and complications common in end-stage renal disease, such as vascular calcification and wasting, the potential role of both general and targeted anticytokine treatment strategies in ESRD patients needs further evaluation.About:
This article is published in Kidney International.The article was published on 2005-04-01 and is currently open access. It has received 830 citations till now. The article focuses on the topics: Proinflammatory cytokine & Systemic inflammation.read more
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Aspects of Immune Dysfunction in End-stage Renal Disease
Sawako Kato,Michał Chmielewski,Michał Chmielewski,Hirokazu Honda,Roberto Pecoits-Filho,Seiichi Matsuo,Yukio Yuzawa,Anders Tranaeus,Peter Stenvinkel,Bengt Lindholm +9 more
TL;DR: The potential role of the immune dysfunction in ESRD as an underlying cause for the high mortality in this patient population is emphasized and the need for more studies in this area is emphasized.
Journal ArticleDOI
Etiology of the Protein-Energy Wasting Syndrome in Chronic Kidney Disease: A Consensus Statement From the International Society of Renal Nutrition and Metabolism (ISRNM)
Juan Jesus Carrero,Peter Stenvinkel,Lilian Cuppari,T. Alp Ikizler,Kamyar Kalantar-Zadeh,George A. Kaysen,William E. Mitch,S. Russ Price,S. Russ Price,Christoph Wanner,Angela Yee-Moon Wang,Pieter ter Wee,Harold A. Franch,Harold A. Franch +13 more
TL;DR: This consensus statement of current knowledge on the etiology of PEW syndrome in CKD is provided to increase awareness, identify research needs, and provide the basis for future work to understand therapies and consequences of Pew.
Journal ArticleDOI
Serum Albumin, C-Reactive Protein, Interleukin 6, and Fetuin A as Predictors of Malnutrition, Cardiovascular Disease, and Mortality in Patients With ESRD
Hirokazu Honda,Abdul Rashid Qureshi,Olof Heimbürger,Peter Bárány,Kai Wang,Roberto Pecoits-Filho,Peter Stenvinkel,Bengt Lindholm +7 more
TL;DR: Comparisons indicate that of these biomarkers, IL-6 level may be the most reliable predictor of CVD and mortality in patients with ESRD.
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The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease
TL;DR: The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease is discussed in this paper, where ACE inhibitors and AII receptor antagonists are used in combination to maximize RAAS inhibition and more effectively reduce proteinuria and GFR decline in diabetic and nondiabetic renal disease.
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Immune cell dysfunction and inflammation in end-stage renal disease
TL;DR: This finding suggests that premature ageing of the immune system in patients with ESRD might be related to a permanent skewing of the haematopoetic stem cell population towards myeloid-generating subsets, similar to that seen in healthy elderly individuals.
References
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