Showing papers in "Laboratory Investigation in 1992"

TL;DR: A tissue inhibitor of metalloproteinases that also inhibits collagenases was found to be a potent inhibitor of fibroblast growth factor-induced angiogenesis, allowing the ready quantitative assessment of angiogenic and anti-angiogenic factors.

TL;DR: The transient expression of nestin in primitive neuroepithelial cells at early stages of human embryogenesis and its abundance in neuroepIThelial tumors suggest a role for nestin IFs in cellular events that precede the exit of embryonic CNS stem cells from the cell cycle and the commitment of the progeny of these stem cells to a specific lineage.

TL;DR: It is proposed that the presence of IL-6 and alpha 2-M immunoreactivity in AD brains is functionally linked and that a sequence of immunological events is part of the pathology of AD.

TL;DR: Data suggest that MMP-3 produced by the chondrocytes and synovial lining cells under stimulation with these cytokines may be important in proteoglycan degradation in human ostoearthritic cartilage.

TL;DR: It is found that endothelial cells, fibroblasts, smooth muscle cells, and cells of the murine Leydig cell line TM3 formed networks on basement membrane matrix in much the same fashion, and the mechanochemical properties of extracellular matrices are able to translate the forces of cellular traction into templates that direct the formation of complex cellular patterns.

TL;DR: VVO are prominent structures in both tumor-supplying and control vessel endothelial cells and provide the primary pathway for macromolecular extravasation in tumor vessels.

TL;DR: The existence of a modulation of the function of the fibroblasts performed by mechanical forces is demonstrated, at least in part, at a pretranslational level.

TL;DR: RECA-1 is believed to be a promising antibody for rat endothelium cell studies, and in particular for further defining nature and function of endothelial cell-specific antigens.

TL;DR: The binding results in conjunction with SAA's existence primarily on HDL during inflammation, and HDL's known "reverse cholesterol transport" function suggest a clear role for SAA in the afferent arm of the reverse cholesterol transport pathway during the process of inflammation.

TL;DR: The results indicate that the malignant phenotype in human glial tumors is associated with an upregulation of the PDGFR-beta on endothelial cells of vessels which vascularize the tumor.

TL;DR: Observations support the role of primary dendritic damage in HIVE in contrast to other neurodegenerative disorders where the primary pathology is presynaptic.

TL;DR: Whereas anti-HLA-DR reactivity in normal prostate is restricted to small numbers of macrophages and includes neither prostate epithelial cells nor prostate T cells, it was found to be dramatically increased in BPH, comprising CD45+ cells and prostate epithel cells as demonstrated by double-staining with anti-cytokeratin or anti-prostate-specific antigen.

TL;DR: The presence of a large number of macrophages in the cellular infiltrates of several types of tumors is demonstrated, suggesting that new strategies of immunotherapy aimed at the use of Macrophages present in many tumors could be developed.

TL;DR: Direct viral mechanisms in the production of cardiomyocyte injury in coxsackievirus B3-infected mice appear to be more important than previously recognized, particularly in the setting of unrestricted viral proliferation.

TL;DR: It is concluded that cellular events including glomerular cell proliferation and macrophage influx are associated with increased gene and protein expression by ECM proteins in the remnant kidney model and may contribute to the development of sclerosis.

TL;DR: Pretreatment of rats with immunoglobulins to rat lymphocytes reduced numbers of circulating lymphocytes but did not afford protection against the hepatotoxic effects of LPS.

TL;DR: These results quantify for the first time a gradual rise in vascularity with tumor progression in the melanocytic system and onset of angiogenesis during the radial growth phase of CMM.

TL;DR: The characteristic histopathologic features of EBV-induced LPD are now recognized and when confirmed with molecular hybridization and immunofluorescent techniques will provide a solid diagnostic approach and, thus, a foundation for developing a sound therapeutic strategy.

TL;DR: The data indicate subtle but definite abnormalities suggesting compromise of the blood-brain barrier in AD that may contribute to its pathogenesis, and support neuropharmacologic and morphologic studies that suggest that a form of denervation microangiopathy may occur in AD brain.

TL;DR: TGF-beta s are involved in regulation of elastin deposition during fetal development and tissue repair, as well as in pathological conditions, and this effect is mediated, at least in part, post-transcriptionally.

TL;DR: These avid interactions with extracellular matrix proteins likely reflect normal functions of the AAPs and may be involved in nucleation events in Alzheimer-type amyloid formation.

TL;DR: These observations provide a morphologic basis for mucosa-associated lymphoid tissue in the female genital tract and may represent the inductive arm of the mucosal immune system in the lower female reproductive tract.

TL;DR: Highly enriched astrocyte and microglial cultures suitable for biochemical or molecular biologic studies were obtained and double immunocytochemical labeling techniques with the proliferating cell nuclear antigen and cell-type specific markers showed a high labeling index, whereas microglia seldom exhibited a similar degree of proliferative activity.

TL;DR: It is shown that heparin and its nonanticoagulant derivatives influence the expression of alpha-smooth muscle actin in fibroblastic cells both in vitro and in vivo and that this effect is probably related to the selection of a particular cell subpopulation.

TL;DR: Analysis of pepsin-resistant proteins synthesized indicated that stretch/relaxation resulted in increases in the relative amounts of types I and III collagens produced/cell and collagen production, and selectively increased the relative amount of type I-homotrimers produced.

TL;DR: Future research is needed to delineate the systemic and local factors associated with CAH; to define interactions of humoral factors in the pathogenesis of hypercalcemia; and to investigate the regulation of transcription, translation, modification, and secretion of hyperCalcemia-inducing factors in normal and neoplastic tissues.

TL;DR: Results show that in non-neoplastic lung tissue, the Clara 10 kd protein gene was expressed in nonciliated cells of both bronchial and bronchiolar epithelium, indicating that, in contrast to previous assumptions, cells with Clara cell-like differentiation in humans may not be restricted to bronchiola cells.

TL;DR: Quantitative immunoblot analysis provides compelling evidence that A68 proteins are generated from tau-proteins in selected regions of the AD brain where neurofibrillary lesions comprised of paired helical filaments accumulate.

TL;DR: It is shown that PKC activation is an important determinant of the H2O2-induced increase in endothelial permeability and the response occurred without LDH release and morphologic evidence of cytolysis.

TL;DR: A syndrome induced by mercuric chloride in BN rats is identified in which there is evidence of tissue injury in many organs, with some features in common with graft-versus-host disease.