Open AccessJournal Article
Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins).
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TLDR
Quantitative immunoblot analysis provides compelling evidence that A68 proteins are generated from tau-proteins in selected regions of the AD brain where neurofibrillary lesions comprised of paired helical filaments accumulate.About:
This article is published in Laboratory Investigation.The article was published on 1992-02-01 and is currently open access. It has received 120 citations till now. The article focuses on the topics: Neurofibrillary tangle & Senile plaques.read more
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Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yasumasa Yoshiyama,Makoto Higuchi,Bin Zhang,Shu-Ming Huang,Nobuhisa Iwata,Takaomi C. Saido,Jun Maeda,Tetsuya Suhara,John Q. Trojanowski,Virginia M.-Y. Lee +9 more
TL;DR: In this paper, the authors studied wild-type and P301S mutant human tau transgenic (Tg) mice and found that tangle formation was preceded by microglial activation.
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Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.
Gregory T. Bramblett,Michel Goedert,Ross Jakes,Sandra E. Merrick,John Q. Trojanowski,Virginia M.-Y. Lee +5 more
TL;DR: It is demonstrated that native A68 does not bind to microtubules (MTs), yet dephosphorylated A68 regains the ability to bind to MTs, and phosphorylation of Ser396 may destabilize MTs in AD, resulting in the degeneration of affected cells.
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Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding
TL;DR: Although MAP kinase efficiently phosphorylates many Ser/Thr-Pro motifs of tau, its effect on microtubule binding is only moderate, and phosphorylation of a single residue, Ser262, has a major effect on binding.
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A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads.
TL;DR: Frontal sections of the temporal lobe of human adult brains are studied for cytoskeleton changes using immunostaining with the antibodies AT8 and Alz-50 and selective silver impregnation methods for neurofibrillary changes of the Alzheimer type to suggest changes which occur in the neuronal processes in the absence of alterations in their immediate surroundings.
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Tau protein in cerebrospinal fluid: a biochemical marker for axonal degeneration in Alzheimer disease?
TL;DR: It is demonstrated that elevated tau/PHFtau levels are consistently found in CSF of AD patients and CSF-tau may therefore be useful as a positive biochemical marker, to discriminate AD from normal aging, PD, and depressive pseudodementia.