Open AccessJournal Article
Serum amyloid A changes high density lipoprotein's cellular affinity. A clue to serum amyloid A's principal function.
Robert Kisilevsky,L Subrahmanyan +1 more
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TLDR
The binding results in conjunction with SAA's existence primarily on HDL during inflammation, and HDL's known "reverse cholesterol transport" function suggest a clear role for SAA in the afferent arm of the reverse cholesterol transport pathway during the process of inflammation.About:
This article is published in Laboratory Investigation.The article was published on 1992-05-30 and is currently open access. It has received 216 citations till now. The article focuses on the topics: Reverse cholesterol transport & Serum amyloid A.read more
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Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host.
Weerapan Khovidhunkit,Min Sun Kim,Riaz A. Memon,Judy K. Shigenaga,Arthur H. Moser,Kenneth R. Feingold,Carl Grunfeld +6 more
TL;DR: APR-induced alterations initially protect the host from the harmful effects of bacteria, viruses, and parasites, however, if prolonged, these changes in the structure and function of lipoproteins will contribute to atherogenesis.
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Serum amyloid A, the major vertebrate acute-phase reactant.
TL;DR: Although the precise role of A-SAA in host defense during inflammation has not been defined, many potential clinically important functions have been proposed for individual SAA family members, including involvement in lipid metabolism/transport, induction of extracellular-matrix-degrading enzymes, and chemotactic recruitment of inflammatory cells to sites of inflammation.
Journal ArticleDOI
The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein
TL;DR: Diana Steel and Alexander Whitehead discuss the gene structure, regulation and possible clinical significance of the most dramatically induced acute phase reactants.
Journal ArticleDOI
Functionally Defective High-Density Lipoprotein: A New Therapeutic Target at the Crossroads of Dyslipidemia, Inflammation, and Atherosclerosis
Anatol Kontush,M. John Chapman +1 more
TL;DR: A preferential increase in circulating concentrations of HDL particles possessing normalized antiatherogenic activity is therefore a promising therapeutic strategy for the treatment of common metabolic diseases featuring dyslipidemia, inflammation, and premature atherosclerosis.
Journal ArticleDOI
The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss.
Daniel R. Cottam,Samer G. Mattar,Emma Barinas-Mitchell,George M. Eid,Lewis H. Kuller,David E. Kelley,Philip R. Schauer +6 more
TL;DR: There appears to be a strong association between obesity and inflammation, thereby rendering obesity a chronic inflammatory state and the success of weight loss surgery in treating the complications associated with obesity is most probably related to the reduction of inflammatory mediators.
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