Journal ArticleDOI
Brain age and Alzheimer's-like atrophy are domain-specific predictors of cognitive impairment in Parkinson's disease.
Daniel Charissé,Guray Erus,Raymond Pomponio,Martin Gorges,Nele Schmidt,Christine Schneider,Inga Liepelt-Scarfone,Oliver Riedel,Kathrin Reetz,Jörg B. Schulz,Daniela Berg,Alexander Storch,Karsten Witt,Richard Dodel,Elke Kalbe,Jan Kassubek,Rüdiger Hilker-Roggendorf,Simon Baudrexel +17 more
TLDR
In this article, an MRI index capturing Alzheimer's disease-like atrophy, and atrophy-based estimates of brain age were computed from longitudinal structural imaging data of 178 PD patients and 84 healthy subjects from the LANDSCAPE cohort.About:
This article is published in Neurobiology of Aging.The article was published on 2022-01-01. It has received 9 citations till now. The article focuses on the topics: Atrophy & Dementia.read more
Citations
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Journal ArticleDOI
Morphological basis of Parkinson disease-associated cognitive impairment: an update
TL;DR: Large-scale clinicopathological correlative studies are warranted to further elucidate the exact neuropathological correlates of cognitive impairment in PD and related synucleinopathies as a basis for early diagnosis and future disease-modifying therapies.
Journal ArticleDOI
Cognitive heterogeneity in Parkinson’s disease: A mechanistic view
TL;DR: A review of the current clinical landscape surrounding cognition in Parkinson's disease can be found in this paper , where the authors discuss how cognitive impairment and dementia may develop in PD based on the spread of the pathological protein alpha-synuclein (aSyn) from neurons in brainstem regions to those in the cortical regions of the brain responsible for higher cognitive functions.
Journal ArticleDOI
Neuroimaging-Based Brain Age Estimation: A Promising Personalized Biomarker in Neuropsychiatry
TL;DR: A review of the clinical applications of brain age estimation in neuropsychiatry and general populations can be found in this article , where the authors provide an introduction to typical neuroimaging modalities, feature extraction methods, and machine-learning models that have been used to develop a brain-age estimation framework.
Journal ArticleDOI
Visuospatial Deficits Are Associated with Pisa Syndrome and not Camptocormia in Parkinson's Disease
Carlo Alberto Artusi,Elisa Montanaro,Roberto Erro,Nils Margraf MPsych,Christian Geroin,Andrea Pilotto,Luca Magistrelli,Francesca Spagnolo,Alberto Marchet,Lidia Sarro,Sofia Cuoco,Marta Sacchetti,M. Riello,Barbara Capellero,Paola Berchialla,Bettina Moeller,Beeke Vullriede,Maurizio Zibetti,Augusto Maria Rini,Paolo Barone,Cristoforo Comi,Alessandro Padovani,Michele Tinazzi,Leonardo Lopiano +23 more
TL;DR: Pisa syndrome (PS) and camptocormia (CC) are postural abnormalities frequently associated with Parkinson's disease (PD), and their pathophysiology remains unclear as mentioned in this paper .
References
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Book
Statistical Power Analysis for the Behavioral Sciences
TL;DR: The concepts of power analysis are discussed in this paper, where Chi-square Tests for Goodness of Fit and Contingency Tables, t-Test for Means, and Sign Test are used.
Book
Analysis of longitudinal data
TL;DR: In this paper, a generalized linear model for longitudinal data and transition models for categorical data are presented. But the model is not suitable for categric data and time dependent covariates are not considered.
Journal ArticleDOI
Mild cognitive impairment as a diagnostic entity
TL;DR: It is suggested that the diagnosis of mild cognitive impairment can be made in a fashion similar to the clinical diagnoses of dementia and AD, and an algorithm is presented to assist the clinician in identifying subjects and subclassifying them into the various types of MCI.
Journal ArticleDOI
N4ITK: Improved N3 Bias Correction
Nicholas J. Tustison,Brian B. Avants,Philip A. Cook,Yuanjie Zheng,A Egan,Paul A. Yushkevich,James C. Gee +6 more
TL;DR: A variant of the popular nonparametric nonuniform intensity normalization (N3) algorithm is proposed for bias field correction with the substitution of a recently developed fast and robust B-spline approximation routine and a modified hierarchical optimization scheme for improved bias field Correction over the original N3 algorithm.
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MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging
TL;DR: The frequently observed "halo" of periventricular hyperintensity in Alzheimer's disease may be of diagnostic importance and high-signal abnormalities in specific cortical regions are likely to reflect disease processes localized to those structures.