Journal ArticleDOI
Localization of distinct monoamine oxidase A and monoamine oxidase B cell populations in human brainstem.
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Both monoamine oxidase A and B were localized in distinct populations of neurons in the lateral and tuberal regions of the hypothalamus, a region shown recently to contain histamine neurons in rats.About:
This article is published in Neuroscience.The article was published on 1988-05-01. It has received 352 citations till now. The article focuses on the topics: Monoamine neurotransmitter & Monoamine oxidase B.read more
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Monoamine oxidase: from genes to behavior.
Jean C. Shih,K. Chen,M. J. Ridd +2 more
TL;DR: MAO A and B knock-out mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders and show increased reactivity to stress.
Journal ArticleDOI
Pathology of Parkinson's disease. Changes other than the nigrostriatal pathway.
TL;DR: In addition to degeneration of the nigrostriatal dopaminergic pathway, a variety of neuronal systems are involved, causing multiple neuromediator dysfunctions that account for the complex patterns of functional deficits.
Journal Article
Autoregulation of Serotonin Neurons: Role in Antidepressant Drug Action
Graciela Piñeyro,Pierre Blier +1 more
TL;DR: The existence of an endogenous vasoconstrictor in blood serum and the presence in the gut of a substance that increases intestinal motility had been known to scientists since the beginning of the century.
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Selective increase of iron in substantia nigra zona compacta of parkinsonian brains.
TL;DR: Histochemical and biochemical determinations of total Iron, iron (II), and iron (III) contents in brain regions from Parkinson's and Alzheimer's diseases have demonstrated a selective increase of total iron content in parkinsonian substantia nigra zona compacta but not in the zona reticulata.
Journal ArticleDOI
Monoamine oxidase inactivation: from pathophysiology to therapeutics.
TL;DR: The intriguing hypothesis that the attenuation of the oxidative stress induced by the inactivation of either MAO isoform may contribute to both antidepressant and antiparkinsonian actions of MAO inhibitors is discussed.
References
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Journal Article
Evidence for the existence of monoamine-containing neurons in the central nervous system. i. demonstration of monoamines in the cell bodies of brain stem neurons.
Dahlstroem A,Fuxe K +1 more
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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
TL;DR: It is proposed that this chemical selectively damages cells in the substantia nigra in patients who developed marked parkinsonism after using an illicit drug intravenously.
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Dynamic response of chest wall and lung injuries in rabbits exposed to air shock waves of short duration.
Carl-Johan Clemedson,Joensson A +1 more
TL;DR: The chest walls of rabbits exposed to steep-fronted air shock waves of short duration produced by 50 g spherical charges of TNT were recorded by means of a mechano-electric motion transducer to study the correlation between the deformations of the chest and the damage inflicted to the underlying organs, especially the lungs.
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Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals.
TL;DR: The results demonstrate a widespread occurrence of 5-HT-positive nerve terminals throughout the central nervous system and the finding that serotonin-containing neurons are present in many nuclei that also include catecholamine- containing neurons makes it necessary to reconsider the terminology of the monoaminergic cell groups.
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A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
TL;DR: The N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey provides a model that can be used to examine mechanisms and explore therapies of parkinsonism and the pathological and biochemical changes produced by NMPTP are similar to the well-established changes in patients with parkinsonistan.