Showing papers in "Parkinsonism & Related Disorders in 2006"

TL;DR: It is concluded that more attention should be paid to caregivers' emotional and physical health, particularly in advancing PD with psychiatric complications and falls, and with caregivers' own satisfaction with their marital and sexual relationship.

TL;DR: Caregivers should be aware of the extent of these behavioural changes of bilateral STN DBS and a risk/benefit evaluation should be performed for individual patients.

TL;DR: It is demonstrated that individuals with Parkinson's disease display impairments in making profitable decisions, as evidenced by poorer performance on the Iowa Gambling Task relative to matched controls, which offers a new perspective on the cognitive impairments that affect social living and adaptive decisions for individuals with Parkinsons disease.

TL;DR: The results extend those from previous studies to show improvement in the temporal variability of two types of rhythmic movements after participation by PD patients in a physical rehabilitation programme, along with changes in glucose uptake in several brain areas involved in sensorimotor processing.

TL;DR: Standard turn tests poorly reflect step count during real-life turning, whereas unobtrusive structured observation reveals the turning strategies people use, so can guide rehabilitation.

TL;DR: This paper is an extensive review of the spectrum of BoNT clinical applications, including gastroenterologic and urologic indications, analgesic management and migraine.

TL;DR: In this longitudinal study of patients with PMD, indices of strong physical health, positive social life perceptions, patient's perception of effective treatment by the physician, elimination of stressors, and treatment with a specific medication contributed to a favorable outcome.

TL;DR: Clinical features in carriers were those of typical, idiopathic Parkinson's disease, however, behavioural abnormalities were frequent, suggesting a more widespread limbic involvement in G2019S carriers.

TL;DR: Psychotherapy and appropriate use of adjunct psychiatric medication can be a successful intervention for PMD.

TL;DR: The results suggest significant extranigral involvement in VH, and the precise etiopathologic mechanisms responsible for the development of VH need further clarification.

TL;DR: Impairment of shifting suggests prefrontal dysfunction, possibly due to disruption of fronto-striatal circuits along the surgical trajectory and/or to high frequency stimulation itself.

TL;DR: The GAITRite system is an efficient, yet effective device in evaluating parkinsonian bradykinesia and can be used as a substitute for the traditional timed test.

TL;DR: PD risk was reduced among male and female smokers, with and without diabetes, however, among diabetics, the PD risk was especially reduced in non-smoking men (OR = 0.09, 95% CI =0.02, 0.02).

TL;DR: The EduPark patient education programme deals with psychosocial problems often faced by people with PD and their carers and resulted in short-term positive effects on their mood, although no statistically significant effects on quality of life and depression were found.

TL;DR: Results indicate a PD-associated deficit with the reorganization of sensory priorities for postural control, and may implicate the basal ganglia as being critical for integration of sensory information forPostural control.

TL;DR: Two cases of early onset PD who experienced paraphilia and hypersexuality when selegiline was initiated, and later developing obsessive-compulsive and punding behavior with the addition of dopamine agonists are reported.

TL;DR: This article reviewed existing studies of familial aggregation in Parkinson's disease and affirmed the importance of ongoing family history research, emphasizing well-designed family studies with extensive, non-exclusive phenotyping and ideally long-term follow-up.

TL;DR: Stride frequency and stride length in patients with Parkinson's disease as well as controls were not rigidly coupled to walking speed and could be manipulated with walking speed aswell as by using spatial and temporal rhythmic visual cues.

TL;DR: The results show that trunk control is affected in PD and suggest that these changes may be related to postural instability and fall risk.

TL;DR: The current status of genetics in RLS is reviewed, providing some methodological guidelines to help future research, and molecular genetic approaches have identified three genomic regions in R LS susceptibility.

TL;DR: Weight loss and daily levodopa dose per kilogram body weight were revealed to be the only significant factors for dyskinesia in addition to disease duration in a cohort of 220 Parkinson's disease patients.

TL;DR: The principal movement disorders associated with CJD are reported and their correlations with neuroradiological and neuropathological findings that could in fact suggest a basal ganglia dysfunction are evaluated.

TL;DR: It is suggested that the basal ganglia lesions may be the result of vasogenic edema attributable to focal hyperemia secondary to abnormal dilatation of small vessels.

TL;DR: MIBG uptake did not significantly correlate with age, disease duration, Hoehn-Yahr stage, Unified Parkinson's Disease Rating Scale (UPDRS) motor score or levodopa equivalent daily doses, and there were no significant correlations between orthostatic hypotension/constipation and cardiac M IBG uptake.

TL;DR: A PD patient is reported in whom chronic bilateral subthalamic nucleus stimulation produced a striking alleviation of camptocormia, a postural disorder responds poorly to levodopa or other medications.

TL;DR: Male gender, orobuccolingual dyskinesias (facial grimacing, lip biting, tongue dysKinesias, platysma contractions and bruxism) and better response to botulinum toxin injections were more frequent in C-OMD but remained a trend.

TL;DR: A mutation frequency of 8.5% in Parkin gene among Indian PD patients is observed based on sequencing and gene dosage analysis of its exons and seven point mutations of which seven are novel and hitherto unreported are identified.

TL;DR: It is suggested that age enhances the sensitivity of dopaminergic neurons to rotenone and should be considered when assessing models of Parkinson's disease.

TL;DR: Correct screening of patients for STN DBS remains an important issue, since the current implantation procedure is not able to take account of potential functional heterogeneity within the target.

TL;DR: Freezing of gait (FOG) is a symptom characterized by difficulty in taking the first step when a patient begins to walk; it is experienced most frequently in Parkinson's disease, and is also one of the major symptoms ofgait apraxia.