Showing papers in "Pharmaceutical Biology in 2020"
TL;DR: Curcumin repressed EMT and the inflammatory response by inhibiting the TLR4/NF-κB and PI3K/AKT pathways, demonstrating its potential utility in RIF treatment.
Abstract: Renal interstitial fibrosis (RIF) is characterized by the accumulation of inflammatory cytokines and epithelial-mesenchymal transition (EMT). Curcumin exerts antifibrogenic, anti-inflammatory and a...
45 citations
TL;DR: It was confirmed that baicalin alleviated post-I/R myocardial injury and reduced inflammation via JAK/STAT pathway, and baicalsin treatment might be recommended as a new approach for myocardIAL ischaemic complications.
Abstract: Baicalin is an active compound which demonstrates cardioprotection effects against myocardial ischaemia/reperfusion injury (MI/RI). To investigate how baicalin protects against myocardial injury an...
44 citations
TL;DR: An overview of the phytochemical and pharmacological properties of RC is provided as a foundation for its clinical application and further research and development of new drugs.
Abstract: Context: Rhizoma Corydalis (RC) is the dried tubers of Corydalis yanhusuo (Y. H. Chou and Chun C. Hsu) W. T. Wang ex Z. Y. Su and C. Y. Wu (Papaveraceae). Traditionally, RC is used to alleviate pai...
42 citations
TL;DR: A systematic discussion of the current development and potential pharmacological effects of Dendrobium officinale polysaccharides in dermatology and advances in moisturising and antioxidant properties from in vivo and in vitro studies are highlighted.
Abstract: Dendrobium officinale Kimura et Migo (Orchidaceae) is a naturally occurring precious traditional Chinese medicine (TCM) originally used in treating yin-deficiency diseases. The main active substanc...
39 citations
TL;DR: It is demonstrated that curcumin can inhibit the growth and invasion of human monocytic leukaemia in vivo, suggesting the possible use ofCurcumin for anti-metastasis in leukaems and the value of determining its unique target.
Abstract: Context: Curcumin, a polyphenolic compound extracted from the rhizome of the tropical plant Curcuma longa L. (Zingiberaceae), has been considered as a cancer chemopreventive drug by America...
37 citations
TL;DR: Natural borneol had the potential to sensitise human glioma cells to cisplatin-induced apoptosis with potential application in the clinic and ROS inhibition by antioxidants effectively improved MAPKs and PI3K/AKT functions and cell viability, indicating that NB enhanced cisplarin-induced cell growth in a ROS-dependent manner.
Abstract: Context: Cisplatin-based chemotherapy was widely used in treating human malignancies. However, side effects and chemoresistance remains the major obstacle.Objective: To verify whether natur...
36 citations
TL;DR: It is concluded that progesterone, at least partially, via attenuation of oxidative stress and neuroinflammation, exerts antidepressant-like effects.
Abstract: Context: Experiencing early-life adversity plays a key role in the development of mood disorders in adulthood. Experiencing adversities during early life period negatively affects brain development...
35 citations
TL;DR: Polygala tenuifolia and its active components have multiplex neuroprotective potential associated with AD, such as anti-Aβ aggregation, anti-Tau protein,anti-inflammation, antioxidant,Anti-neuronal apoptosis, enhancing central cholinergic system and promote neuronal proliferation.
Abstract: Alzheimer’s disease (AD) is a chronic neurodegenerative disease that originates from central nervous system lesions or recessions. Current estimates suggest that this disease affects over 35 millio...
33 citations
TL;DR: The results show that emodin inhibits oxidative liver injury via the AMPK/YAP mediated pathway and decreased APAP-induced hepatic damage, as indicated by decreases in antioxidant genes as well as tissue damage.
Abstract: Context: Emodin is a compound in Rheum undulatum Linne (Polygonaceae) that has been reported to exert anti-inflammatory, antibacterial, and antiallergic effects.Objective: Oxidative stress is a cau...
28 citations
TL;DR: XNJ improved cerebral ischaemia/reperfusion injury through inhibiting the inflammatory response via the SIRT1 pathway, which may be a useful target in treating cerebral I/R injury.
Abstract: XingNaoJing injection (XNJ), extracted from a traditional compound Chinese medicine Angong niuhuang pill, is well known for treating stroke in the clinic, but the specific effects and mechanisms re...
28 citations
TL;DR: The data show that the oral administration of GA could alleviate the noxious effects of DIC on the antioxidant defense system and liver tissue and were also ameliorated by GA oral administration.
Abstract: Diclofenac (DIC) is an NSAID and consumption of this drug creates side effects such as liver injury. Gallic acid (GA), a natural component of many plants, is used as an antioxidant agent. This stud...
TL;DR: Kai-Xin-San (KXS) has been used to treat Alzheimer's disease (AD) for thousands of years as mentioned in this paper, however, no quantitative data regarding AD treatment using KXS are available.
Abstract: Kai-Xin-San (KXS) has been used to treat Alzheimer’s disease (AD) for thousands of years. However, no quantitative data regarding AD treatment using KXS are available. Moreover, its active compound...
TL;DR: In vitro evidence is provided that matrine was able to protect PC12 cells against LPS-evoked damage and the neuroprotective properties of matrine may be due to its regulation of miR-9 expression as well as JNK and NF–κB pathways.
Abstract: Context: Matrine is a well-known anti-inflammatory quinolizidine alkaloid derived from leguminous plant Sophora flavescens Ait. (Leguminosae).Objective: This study was designed to uncover the poten...
TL;DR: EMS exhibits anti-arthritic activity in the AA model by regulating the balance of cytokines and the ratio of Th17 and Treg cells.
Abstract: Context: Er Miao San (EMS) is a traditional Chinese medicine composed of Atractylodis Rhizoma and Phellodendri Cortex in a 1:1 weight ratio. EMS has been used to treat rheumatism in China f...
TL;DR: Kalanchoe blossfeldiana ethanol extract is a potential candidate for cancer and bacterial infection treatment and the biological effects of Kalanchoe extracts are not dependent on the presence and amount of bufadienolides in the plant extracts.
Abstract: Kalanchoe species (Crassulaceae) are widely used in traditional medicine as remedies in infectious diseases and cancer treatment. Cytotoxic and antimicrobial activities of Kalanchoe daigremontiana ...
TL;DR: The potential role of LBPs in reducing the uric acid level in hyperuricemic mice is demonstrated and the results are valuable for the development of new anti-hyperuricaemia agents from LBPs.
Abstract: Lycium barbarum L. (Solanaceae) polysaccharides (LBPs) are important active constituents that have demonstrated kidney protection. This study investigated the effect of LBPs on hyperuricaemia and e...
TL;DR: It is reported that TCM with different “cold/hot” properties have different effects on the variation of cells, and the changes in cellular temperature are speculated to be caused by the alteration of intracellular calcium influx mediated by TRPV4.
Abstract: Context: It is common sense that chewing a mint leaf can cause a cooling feeling, while chewing ginger root will produce a burning feeling. In Traditional Chinese Medicine (TCM), this phenomenon is...
TL;DR: RDS is a stable, cheaper, and suitable preparation with potent immunoregulatory and anti-inflammatory activities and could be an appropriate preparation for clinic use of resveratrol.
Abstract: Context: Resveratrol is a natural polyphenol compound. It exhibits antitumor, immunostimulatory, and antiviral activities. However, poor water solubility and structural instability limit its admini...
TL;DR: F-AOH inhibits ethanol-induced gastric mucosal damage, provides a theoretical basis for galangal in the treatment of other causes of GU, and promotes the application of galanga in thetreatment of GU.
Abstract: Alpinia officinarum Hance (Zingiberaceae) is traditionally used to treat inflammation, pain, colds and digestive diseases. To investigate the potential protective mechanism of total flavonoids from...
TL;DR: Treatment of methotrexate-induced nephrotoxic rats with polyherbal combination significantly improved the kidney function markers, oxidative stress markers and histological parameters and the developed combination was found to be effective in nephroprotective activity.
Abstract: Context: Nephrotoxicity is a renal dysfunction that arises from direct exposure to environmental chemicals or as a side effect of therapeutic drugs. Boerhaavia diffusa Linn. (Nyctaginaceae), Rheum ...
TL;DR: Although experimental data supports the beneficial effects of this compound, acetylshikonin cannot be considered as a therapy drug without further investigations, especially, on the toxicity and pharmacokinetics.
Abstract: Acetylshikonin, a naphthoquinone derivative, is mainly extracted from some species of the family Boraginaceae, such as Lithospermum erythrorhizon Sieb. et Zucc., Arnebia euchroma (Royle) Johnst., a...
TL;DR: 5-CQA significantly increases the ARE reporter gene activity and downstream antioxidant proteins, including glutamate cysteine ligase (GCL), hemeoxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1, and Sestrin2.
Abstract: 5-Caffeoylquinic acid (5-CQA) is one of the most abundant compounds found in natural foods including coffee. We investigated whether 5-CQA had a cytoprotective effect through the NF-E2-related fact...
TL;DR: The beneficial effects of QL on DOX-induced CHF in rats are mediated by reduction in myocardial fibrosis, promotion of TGF-β3/Smad7, and inhibition of T GF-β1/ Smad3, which may also modulate specific miRNAs.
Abstract: Context: Therapeutic doxorubicin administration is restricted as this anticancer drug may be cardiotoxic. The traditional Chinese medicine qiliqiangxin has been approved for clinical treatment of c...
TL;DR: This review introduces the typical methods of liquid excipients processing, summarizes the influence on chemical composition, pharmacological efficacy, and expounds the ways and mechanisms of liquidexcipients to change the properties of drugs, enhance the efficacy, eliminate or reduce toxicity and adverse reaction.
Abstract: Context: The Chinese medicinal materials originate from animals, plants, or minerals must undergo appropriate treatment before use as decoction pieces. Processing of Chinese medicines with liquid excipients is a pharmaceutical technique that transforms medicinal raw materials into decoction pieces which are significantly different from the original form. During processing, significant changes occur in chemical constituents, which inevitably affects clinical efficacy. At present, the liquid materials in processing mainly involve wine, vinegar, honey, saline water, ginger juice, herbal juice, etc.Objective: This review introduces the typical methods of liquid excipients processing, summarizes the influence on chemical composition, pharmacological efficacy, and expounds the ways and mechanisms of liquid excipients to change the properties of drugs, enhance the efficacy, eliminate or reduce toxicity and adverse reaction.Methods: English and Chinese literature from 1986 to 2020 was collected from databases including Web of Science, PubMed, Elsevier, Chinese Pharmacopoeia 2015, and CNKI (Chinese). Liquid excipients, processing, pharmacological effects, synergism, chemical constitution, traditional Chinese medicine (TCM) were used as the key words.Results: Liquid excipients play a key role in the application of TCM. Processing with proper liquid excipients can change the content of toxic or active components by physical or chemical transformation, decrease or increase drug dissolution, alter drug pharmacokinetics, or exert their own pharmacological effects. Thus, processing with liquid excipients is essential to ensure the safety and efficacy of TCM in clinic.Conclusion: This article could be helpful for researchers who are interested in traditional Chinese herbs processed with liquid excipients.
TL;DR: PNP apparently exerted beneficial effects on kidney function and improved the metabolism of serum lipids by CM, which is the first meta-analysis investigating adjuvant PNP therapy for DKD.
Abstract: Context: Panax notoginseng (Burk.) F.H. Chen (Araliaceae) preparations (PNP) are traditional Chinese medicines used as adjuvant therapeutics for diabetic kidney disease (DKD).Objective: To ...
TL;DR: The anti-RA effect of ACR may be attributed to its anti-proliferative and anti-migration effects on synovial fibroblasts, and data suggest that Cinnamomi ramulus may have therapeutic value for the treatment of RA.
Abstract: Cinnamomi ramulus, the dry twig of Cinnamomum cassia Presl. (Lauraceae), has been reported to exert several activities such as antitumor, anti-inflammatory, and analgesic effects. This study invest...
TL;DR: The potential use of D. linearis as a new source for future hepatoprotective drug development is supported after preliminary screening of EADL revealed the presence of saponins, tannins and flavonoids with further HPLC analysis demonstrating the presenceof rutin and quercetin.
Abstract: Dicranopteris linearis L. (Gleicheniaceae) leaves have been reported to exert hepatoprotective activity. The hepatoprotective and antioxidant effects of ethyl acetate partition of D. linearis (EADL...
TL;DR: LD extract increased 5-HT and MT levels, reduced NE level in the hypothalamus, and upregulated the expression of GABAA R and 5- HT1A in hypothalamus to improve the pathology of neurons inThe hypothalamus.
Abstract: Lilium davidii var. unicolour Cotton (Lilium genus, Liliaceae) is an edible plant and a herb used in China to alleviate insomnia. To investigate the alleviating insomnia mechanism of L. davidii (LD...
TL;DR: The present study is the first to show that SLF may exert neuroprotective effect in AD rats via the AKT/GSK-3β signalling pathway, thereby serving as evidence for the potential utility of SLF as an effective drug against AD.
Abstract: The seed of Litchi chinensis Sonn., a famous traditional Chinese medicine, was recently reported to enhance cognitive function by inhibiting neuronal apoptosis in rats. We determined whether the se...
TL;DR: Crocus sativus and its petal flavonoid, kaempferol, showed relatively potent therapeutic effects on respiratory disorders by relaxation of tracheal smooth muscles via stimulatory or blocking effects on β-adrenoceptor and muscarinic receptors, respectively.
Abstract: Crocus sativus L. (Iridaceae), or saffron, has been used as food additives and spices. In the traditional medicine of Iran, C. sativus has been used for the treatment of liver disorders, coughs, an...