Showing papers in "Sleep Medicine in 2004"

TL;DR: The marked under-diagnosis and inappropriate treatment of RLS indicates that PCPs need better education about this condition, and recognizing how often disrupted sleep results from RLS should improve diagnosis.

TL;DR: It is concluded that there may be an iron-dopamine connection central to the pathophysiology of RLS for at least some if not most patients with this disorder.

TL;DR: The high prevalence of RLS and other sleep disorders among uremics requires careful investigation of nocturnal sleep; although often underdiagnosed, correct identification of these disorders can lead to better therapy and improvement of clinical conditions and quality of life.

TL;DR: Exogenous melatonin has been shown to entrain the clock in individuals with no light perception and free-running circadian rhythms, and studies have reported beneficial effects of melatonin for treatment of certain insomnias.

TL;DR: Augmentation and tolerance are more common with extended pramipexole treatment of RLS than has been previously reported in preliminary studies, but these complications are generally manageable by earlier dosing or small dose increases of this agent, and only rarely require medication discontinuation.

TL;DR: IV iron therapy significantly improved the mean global RLS symptom severity, TST, hours with RLS symptoms and PLMS, but on an individual basis failed to produce any response in 3 of the 10 subjects who were fully treated.

TL;DR: It is confirmed that the diagnosis of narcolepsy can be delayed for many years particularly when cataplexy is absent initially and the delay in diagnosis in the UK appears to be decreasing, probably through greater doctor and patient awareness of the clinical manifestations of narCOlepsy.

TL;DR: Severe snoring, higher sleep efficiency and increased total arousals in polysomnography seem to predict EDS, while stepwise logistic regression analysis identified only sleep efficiency, total arousal, and severity of snoring as significant predictive factors.

TL;DR: RLS in pregnant women is frequently unrecognized; they are often worried about the symptoms and do not receive an adequate explanation by doctors, and the importance of folate and iron supplementation during pregnancy in preventing RLS is unclear.

TL;DR: OSAHS patients with comorbid insomnia had increased levels of depression, anxiety and stress compared to patients with OSAHS-only, and both patient groups reported similar and significant levels of dysfunctional beliefs about sleep.

TL;DR: MSA patients, especially those with associated stridor, commonly display impaired breathing and abnormal control of respiratory and limb muscles during sleep, indicating a diffuse impairment of sleep homeostatic integration that should be included within the diagnostic features of MSA.

TL;DR: Satisfactory weight loss associated with improvement of OSAS could be achieved by means of a cognitive-behavioral weight loss program.

TL;DR: Response to dopaminergic drugs indicates that dopamine receptors are implicated, and although much progress has been made in diagnosis and treatment in the last decade, more is needed for complete elucidation of the etiology and pathophysiology of RLS.

TL;DR: Extended sleep leads to substantial improvements in daytime alertness, reaction time, and mood in healthy young adults.

TL;DR: The changes in creatine levels in the hippocampal area are suggested to represent adjustments to brain bioenergetics, similar to those seen in ischemic preconditioning, and may reflect the different susceptibility of these tissues to hypoxic damage in OSA.

TL;DR: In this article, a case-control design was used to compare the body mass index (BMI) of 31 narcolepsy children at the time of diagnosis with that of healthy, age and gender-matched controls.

TL;DR: Nasal CPAP is a safe and effective treatment of SDB during pregnancy and significantly improved all scales compared to entry.

TL;DR: The current available data on the evolution of insomnia is summarized, a model that warrants further research attention and discussion is proposed and the effects of treatment in long-term disease progression are proposed.

TL;DR: Trazodone is effective in the treatment of antidepressant-associated insomnia and significantly increased total sleep time, percentage of stages 3+4, sleep efficiency index, sleep continuity index and decreased percentage of stage 1, number of awakenings, stage shifts compared to the baseline.

TL;DR: STN DBS seems to be an effective therapeutic option for the treatment of advanced Parkinson's disease because it improves the cardinal symptoms and also seems to improve sleep architecture.

TL;DR: Results obtained with objective measures support previous findings that subjective sleep quality following burn injuries is poor, and strengthen the evidence of a relationship between sleep and sensitivity to pain.

TL;DR: Converging lines of evidence suggest that mesocorticolimbic dopamine circuits are involved in promoting wakefulness, while a less studied diencephalospinal dopamine system might underly the sensorimotor dysfunction of Restless Legs Syndrome.

TL;DR: The temporal pattern of cardiac and EEG activities changes concomitant with PLMs in NREM sleep is described using time frequency analysis technique and a similar pattern seems to encompass the CAP phenomenon.

TL;DR: Functional neuroimaging studies may contribute to elucidate pathophysiological mechanisms of the restless legs syndrome (RLS) which still remain unclear, but both techniques are not yet clinically relevant methods to differentiate RLS from other movement disorders during sleep.

TL;DR: The SF-36 form is a reliable outcome measure for hypersomniac disorders and seriously impacts patients' HRQoL in terms of physical and mental well-being and impairs physical and emotional functions, restricting social life.

TL;DR: Social differences (represented by a lower family income) were an observed factor in the distribution of EDS, as were gender and insomnia, indicating that it is an important health problem, even in a small community of a developing country.

TL;DR: The HLA association in humans suggests possible autoimmune activity against hypothalamic Hcrt-containing cells against narcoleptic patients, and Hypocretins may also have roles in regulating normal sleep, appetite, neuroendocrine function and energy metabolism, uniquely positioning them as a link between multiple important behaviors.

TL;DR: The findings indicate that insomnia is a frequent disturbance in the Italian primary care population, is associated with high risk of co-morbid conditions, and results in increased use of health-care resources.

TL;DR: It was showed that RLS was common among female blood donors and women with RLS were more iron-deficient than those without and were affected by impaired sleep.

TL;DR: The hypothesis that NREM and REM are complementary for memory processes during sleep, thanks to their close interaction within the NREM-REM cycle, is presented and experimental data are discussed which prove the critical role of the sleep cycle for the morning recall of verbal material.