Clinical and endoscopic characteristics do not reliably differentiate PPI-responsive esophageal eosinophilia and eosinophilic esophagitis in patients undergoing upper endoscopy: a prospective cohort study.
Evan S. Dellon,Olga Speck,Kimberly Woodward,Jessica H. Gebhart,Ryan D. Madanick,Sidney L. Levinson,Karen J. Fritchie,John T. Woosley,Nicholas J. Shaheen +8 more
TLDR
Although EoE was seen in nearly a quarter of patients with dysphagia, PPI-REE was almost as common, and accounted for over one-third of those with ≥15 eos/hpf, and none were significantly associated with disease status on multivariable analysis.About:
This article is published in The American Journal of Gastroenterology.The article was published on 2013-12-01 and is currently open access. It has received 207 citations till now. The article focuses on the topics: Eosinophilic esophagitis & Prospective cohort study.read more
Citations
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Journal ArticleDOI
Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults.
Alfredo J. Lucendo,Javier Molina-Infante,Ángel Arias,Ulrike von Arnim,Albert J. Bredenoord,Christian Bussmann,Jorge Amil Dias,Mogens Bove,Jesús González-Cervera,Helen Larsson,Stephan Miehlke,Alexandra Papadopoulou,Joaquín Rodríguez-Sánchez,Alberto Ravelli,Jukka Ronkainen,Cecilio Santander,Alain M. Schoepfer,Martin Storr,Ingrid Terreehorst,Alex Straumann,Stephen Attwood +20 more
TL;DR: Evidence-based recommendations for EoE diagnosis, treatment modalities, and patients’ follow up are proposed in the guidelines, and expert opinion and best clinical practice are provided.
Journal ArticleDOI
Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.
Evan S. Dellon,Chris A. Liacouras,Javier Molina-Infante,Glenn T. Furuta,Jonathan M. Spergel,Noam Zevit,Stuart J. Spechler,Stephen Attwood,Alex Straumann,Seema S. Aceves,Jeffrey A. Alexander,Dan Atkins,Nicoleta C. Arva,Carine Blanchard,Peter A Bonis,Wendy Book,Kelley E. Capocelli,Mirna Chehade,Edaire Cheng,Margaret H. Collins,Carla M. Davis,Jorge Amil Dias,Carlo Di Lorenzo,Ranjan Dohil,Christophe Dupont,Gary W. Falk,Cristina Targa Ferreira,Adam T. Fox,Nirmala Gonsalves,Sandeep K. Gupta,David A. Katzka,Yoshikazu Kinoshita,Calies Menard-Katcher,Ellyn Kodroff,David C. Metz,Stephan Miehlke,Amanda B. Muir,Vincent A. Mukkada,Simon Murch,Samuel Nurko,Yoshikazu Ohtsuka,Rok Orel,Alexandra Papadopoulou,Kathryn A. Peterson,Hamish Philpott,Philip E. Putnam,Joel E. Richter,Rachel Rosen,Marc E. Rothenberg,Alain M. Schoepfer,Melissa Scott,Neil Shah,Javed Sheikh,Rhonda F. Souza,Mary Jo Strobel,Nicholas J. Talley,Michael F. Vaezi,Yvan Vandenplas,Mario C. Vieira,Marjorie M. Walker,Joshua B. Wechsler,Barry K. Wershil,Ting Wen,Guang Yu Yang,Ikuo Hirano,Albert J. Bredenoord +65 more
TL;DR: An updated diagnostic algorithm for EoE was developed, with removal of the PPI trial requirement, and the evidence suggests that PPIs are better classified as a treatment for esophageal eosinophilia that may be due to EOE than as a diagnostic criterion.
Journal ArticleDOI
Presentation and Epidemiology of Gastroesophageal Reflux Disease.
TL;DR: There is substantial overlap between symptoms of GERD and those of eosinophilic esophagitis, functional dyspepsia, and gastroparesis, posing a challenge for patient management.
Journal ArticleDOI
Proton pump inhibitor-responsive oesophageal eosinophilia: an entity challenging current diagnostic criteria for eosinophilic oesophagitis
Javier Molina-Infante,Albert J. Bredenoord,Edaire Cheng,Evan S. Dellon,Glenn T. Furuta,Sandeep K. Gupta,Ikuo Hirano,David A. Katzka,Fouad J. Moawad,Marc E. Rothenberg,Alain M. Schoepfer,Stuart J. Spechler,Ting Wen,Alex Straumann,Alfredo J. Lucendo +14 more
TL;DR: Evidence shows that patients with PPI-REE and patients with EoE at baseline are clinically, endoscopically and histologically indistinguishable and have a significant overlap in terms of features of Th2 immune-mediated inflammation and gene expression, which supports the concept that P PI-REE represents a continuum of the same immunological mechanisms that underlie EiE.
Journal ArticleDOI
Efficacy of Proton Pump Inhibitor Drugs for Inducing Clinical and Histologic Remission in Patients With Symptomatic Esophageal Eosinophilia: A Systematic Review and Meta-Analysis
TL;DR: PPI therapy induces clinicohistologic remission in half of patients with symptomatic esophageal eosinophilia, and this finding should be interpreted with caution because of poor-quality evidence, heterogeneity, and publication bias.
References
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Journal ArticleDOI
Eosinophilic esophagitis: Updated consensus recommendations for children and adults
Chris A. Liacouras,Glenn T. Furuta,Ikuo Hirano,Dan Atkins,Stephen Attwood,Peter A Bonis,A. Wesley Burks,Mirna Chehade,Margaret H. Collins,Evan S. Dellon,Ranjan Dohil,Gary W. Falk,Nirmala Gonsalves,Sandeep K. Gupta,David A. Katzka,Alfredo J. Lucendo,Jonathan E. Markowitz,Richard J. Noel,Robert D. Odze,Philip E. Putnam,Joel E. Richter,Yvonne Romero,Eduardo Ruchelli,Hugh A. Sampson,Alain M. Schoepfer,Nicholas J. Shaheen,Scott H. Sicherer,Stuart J. Spechler,Jonathan M. Spergel,Alex Straumann,Barry K. Wershil,Marc E. Rothenberg,Seema S. Aceves +32 more
TL;DR: A new conceptual definition is proposed highlighting that EoE represents a chronic, immune/antigen-mediated disease characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation.
Journal ArticleDOI
Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment.
Glenn T. Furuta,Chris A. Liacouras,Margaret H. Collins,Sandeep K. Gupta,Chris Justinich,Phil E. Putnam,Peter A Bonis,Eric Hassall,Alex Straumann,Marc E. Rothenberg +9 more
TL;DR: A multidisciplinary task force of 31 physicians assembled with the goal of determining diagnostic criteria and making recommendations for evaluation and treatment of children and adults with suspected eosinophilic esophagitis (EE) provided current recommendations for care of affected patients.
Journal ArticleDOI
ACG Clinical Guideline: Evidenced Based Approach to the Diagnosis and Management of Esophageal Eosinophilia and Eosinophilic Esophagitis (EoE)
Evan S. Dellon,Nirmala Gonsalves,Ikuo Hirano,Glenn T. Furuta,Chris A. Liacouras,David A. Katzka +5 more
TL;DR: Recommendations developed by adult and pediatric gastroenterologists are provided for the evaluation and management of patients with eosinophilic–esophageal disorders.
Journal ArticleDOI
Histopathologic variability and endoscopic correlates in adults with eosinophilic esophagitis.
TL;DR: Significant histologic variability exists among biopsy specimens from individual patients with EE and necessitates multiple biopsies to improve diagnostic sensitivity, and marked variability within and between biopsy specimen of individual patients is revealed.
Journal ArticleDOI
Association of eosinophilic inflammation with esophageal food impaction in adults.
Tusar K. Desai,Veslav Stecevic,Chung-Ho Chang,Neal S. Goldstein,Kamran Badizadegan,Glenn T. Furuta +5 more
TL;DR: Clinopathologic features of adults with esophageal food impaction evaluated demonstrated increased CD8 lymphocytes and major basic protein deposition in their squamous epithelium, indicating a significant number likely have eosinophilic esophagitis.
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