Showing papers in "The Breast in 2019"

TL;DR: In this paper, the association between physical activity (PA) after breast cancer diagnosis and all-cause mortality, breast cancer mortality, and/or breast cancer recurrence was further quantified.

TL;DR: Low levels of both NLR and PLR may indicate a status of immune system activation that may predict pCR in breast cancer patients treated with NACT, and was independent from common prognostic factors such as grading, Ki67, and molecular subtypes.

TL;DR: Young women with newly diagnosed breast cancer have several concerns, including, but not limited to, fertility, and the HOHO European study provides valuable information to develop targeted interventions.

TL;DR: Brazilian women have a higher risk of being diagnosed with late stage breast cancer and younger age than in high-income countries and Luminal-like disease is the most common molecular subtype in the country.

TL;DR: The role of homologous recombination deficiency (HRD) as both predictive and prognostic factor in different settings of TNBC patients treated with DNA damaging drugs and poly ADP ribose polymerase (PARP) inhibitors is focused on.

TL;DR: The results do not support the use of metformin with chemotherapy in non-diabetic MBC patients and meetformin showed no significant effect on RR, PFS or OS.

TL;DR: Treatment with palbociclib in combination with AI or fulvestrant demonstrated favorable effectiveness in terms of progression-free and survival rates in this first real-world assessment of clinical outcomes in US patients with HR+/HER- ABC/MBC.

TL;DR: A comprehensive overview of the current state of knowledge of BCRL management is provided, novel advantages in the assessment of pre-operative evaluation and risk prediction are provided and strengths and weaknesses of diagnostic and treatment strategies currently accessible in clinical practice are discussed.

TL;DR: Concomitant treatment of CDK4/6 and radiotherapy seems well tolerated; high grade hematological toxicity is common, but did not change treatment course in the majority of patients.

TL;DR: New mechanistic hypotheses are provoked that link resistance to endocrine agents to specific defects in single strand break repair, which are associated with increased mortality from ER+ breast cancer.

TL;DR: It is shown that circulatory exosomal HOTAIR is present in breast cancer patients and the pathological correlation with the disease is explored and provides a molecular basis to develop novel liquid biopsy biomarkers and targeted therapies with improved precision for malignant breast cancer.

TL;DR: An updated nomogram/calculator that could predict ODX results without performing the test by using clinicopathologic characteristics of BC available from pathology reports is published and will continue serving as a surrogate for BC patients for which ODX testing is not affordable, available or necessary.

TL;DR: Mutation status, family history, and PBC treatment are key factors for CBC risk, and age at PBC diagnosis, BMI, lobular histology and hormone receptor status should be considered in combination with key factors to accurately predict CBC risk.

TL;DR: Issues of the best chemotherapy backbone, the possible detrimental role of steroids and growth factor support, risk of overtreatment, differences between PD-1 and PD-L1 inhibition and if the authors can use a biomarker to effectively escalate or de-escalate chemotherapy and/or use checkpoint inhibition in this setting will be faced.

TL;DR: The results from this study support the importance of examining mediating factors in the effects of cancer treatment on cognition, particularly depression, following cancer treatment and suggest physical activity may reduce the risk of depression and cognitive impairment in breast cancer survivors.

TL;DR: Comprehensive genomic profiling is performed in the largest MPBC dataset to date to assess for other potential biomarkers of immune response and find high PD-L1 expression.

TL;DR: The single-stage direct-to-implant prepectoral implant placement after NSM with complete coverage of the implant with ADM or synthetic mesh represents a novel and feasible technique for breast reconstruction.

TL;DR: A nomogram was constructed to predict the OS for IBC patients based on the SEER database and to provide accurate and individualised survival predictions.

TL;DR: Investigating women's perceptions of the cosmetic outcome of their implant-based breast reconstruction, body image, sexuality, anxiety/depressive symptoms, and health-related quality of life 6-20 years after bilateral risk-reducing mastectomy found problems with body image appeared to persist long time post-RRM.

TL;DR: The latest studies with HDACi in breast cancer are summarized from the emerging data in the translational research until its possible applicability in the clinical practice.

TL;DR: The VICTOR-6 study provides new data coming from the real-life setting, by adding new information regarding the use of mCHT as an option of treatment for MBC patients.

TL;DR: It is found that axillary lymph node dissection performed in combination with specific breast surgical procedures did not result in a significant improvement in survival, and the effect of locoregional surgery has been underestimated in pMBC patients.

TL;DR: Mastectomy followed by flap fixation with either sutures or adhesive tissue glue reduces the number of seroma aspirations when compared to simple wound closure.

TL;DR: The prognosis for benign PTB is excellent and can be cured with surgery alone and the role of ART in patients with borderline and malignant PTB treated with BCS and with surgical margin < 1 cm remains uncertain.

TL;DR: The impact of depression and pessimism on physical, psychological, social, and quality-of-life aspects and the importance of evaluating them in patients who are going to initiate adjuvant chemotherapy for breast cancer are revealed.

TL;DR: There is no difference between conventional fractionation and hypofractionated in terms of efficacy when it comes to local recurrence, loco-regional recurrence), distance recurrent, disease-free survival and mortality and no difference concerning safety when the authors assess the occurrence of fibrosis, ischemia and ribs fractures.

TL;DR: There was a decrease in rates of ALND that started after year 2010 through the end of the study period, indicating the need to spread unified clinical guidelines in Europe to allow for homogeneous evidence-based practice patterns.

TL;DR: Reliable discrimination of malignant from normal, fat-rich breast tissue to a depth compatible with surgical margin assessment requirements was achieved with mm-wave spectroscopy.

TL;DR: Closer follow-ups, tailor-made information about the proven benefits of ET, and keeping a normal body mass index (BMI) may improve adherence to ET in postmenopausal women with breast cancer.

TL;DR: There is a substantial difficulty in the routine use of multigene panels if management guidelines and recommendations for testing relatives are not previously defined for each gene, and clinical validity and utility are not established for all genes.