Showing papers in "The Journal of Urology in 2015"

TL;DR: This guideline amendment focused on four topic areas: mirabegron, peripheral tibial nerve stimulation, sacral neuromodulation and BTX-A.

TL;DR: This amendment is to provide an updated clinical framework for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome based upon data received since the publication of original guideline in 2011.

TL;DR: This guideline is a clinical framework for the diagnosis and treatment of Peyronie's disease and contains evidence-based statements of Strong, Moderate, or Conditional Recommendation based on benefits and risks/burdens to patients.

TL;DR: This study demonstrates that a new molecular test, the Genomic Prostate Score, which can be performed on a patient's original prostate needle biopsy, can predict the aggressiveness of the cancer and help men make decisions regarding the need for immediate treatment of their cancer.

TL;DR: The understanding of the decline in renal function after partial nephrectomy has advanced considerably, including better appreciation of its magnitude and impact in various settings, possible etiologies and potential preventive measures.

TL;DR: The new phi test outperforms its individual components of total, free and [-2]proPSA for the identification of clinically significant prostate cancer and may be useful as part of a multivariable approach to reduce prostate biopsies and over diagnosis.

TL;DR: Cytoreductive radical prostatectomy is feasible in well selected men with metastatic prostate cancer who respond well to neoadjuvant androgen deprivation therapy and reduces the risk of locally recurrent prostate cancer and local complications.

TL;DR: This guideline should be used in conjunction with recent systematic literature reviews and an understanding of individual patients’ treatment goals to provide a rational basis for the management of patients with non‐metastatic castration‐resistant prostate cancer (CRPC).

TL;DR: Initial surveillance is used much more commonly than previously reported, but the likelihood of a patient being placed on surveillance depends strongly on where he is treated, which suggests growing acceptance of this strategy for reducing overtreatment.

TL;DR: Compared to systematic, transperineal biopsy as a reference test, magnetic resonance imaging targeted biopsy alone detected as many Gleason score 7 or greater tumors while simultaneously mitigating the detection of lower grade disease.

TL;DR: The availability of newly approved treatment options for metastatic castration resistant prostate cancer is not matched with conclusive data on optimal sequencing strategies and resistance patterns, so identifying predictors of response and relevant biomarkers will allow therapies to be more precisely tailored to individual patient profiles.

TL;DR: The population level burden of preoperatively misclassified benign renal masses is substantial and increasing rapidly, paralleling increases in surgically resected small renal cell carcinoma.

TL;DR: This randomized study showed similar prostate cancer detection rates between targeted prostateBiopsy guided by magnetic resonance imaging and the combination of targeted biopsy and systematic transrectal ultrasound-guided prostate biopsy.

TL;DR: Serum miRNAs miR-371a-3p allowed for sensitive and specific identification of patients with testicular germ cell tumor, thus, outperforming human chorionic gonadotropin or α1-fetoprotein testing, and was increased in nonseminoma compared to seminoma cases.

TL;DR: Magnetic resonance imaging underestimates histologically determined tumor boundaries, especially for lesions with a high imaging suspicion score and a high Gleason score, which would consistently ensure treatment of the entire histological tumor volume during focal ablative therapy.

TL;DR: In this article, a single-centre prospective development study was conducted to determine the early genitourinary functional and cancer control outcomes of index lesion ablation using high-intensity focused ultrasound.

TL;DR: Significant prostate cancer related morbidity and mortality remained rare at intermediate followup and prostate specific antigen density was independently associated with biopsy reclassification and treatment while on active surveillance.

TL;DR: Local therapy with radical prostatectomy and intensity modulated radiation therapy but not with conformal radiation therapy was associated with a survival benefit in men with metastatic prostate cancer, and this finding warrants prospective evaluation in clinical trials.

TL;DR: It is suggested that CD8(+) T cells might have a significant role in tumor immunity by expressing CD103 in intratumor regions of bladder urothelial cell carcinoma tissues, and could represent a favorable prognostic predictor of overall and recurrence-free survival.

TL;DR: The PHI detected aggressive prostate cancer with better specificity than total and percent free prostate specific antigen in a biopsy naïve population and could be a useful tool to decrease unnecessary prostate biopsies.

TL;DR: It is suggested that infertile men are at an increased risk of all cancers in the years after infertility evaluation and future research should focus on confirming these associations and elucidating pathways between infertility and cancer.

TL;DR: There was a 28% decrease in incident diagnoses of prostate cancer in the year after the USPSTF draft recommendation against prostate specific antigen screening, and subgroups of age, comorbidity, race, income and insurance showed comparable decreases in incident prostate cancer following the draft guideline.

TL;DR: The current literature regarding urological management of spina bifida from prenatal diagnosis to adulthood is reviewed to inform clinical guidelines and create a framework for disease management.

TL;DR: Followup at 1 year demonstrated that photoselective vaporization of the prostate produced efficacy outcomes similar to those of transurethral resection of the Prostate Symptom Score, and confirmed the therapeutic durability of both procedures.

TL;DR: Overall this literature suggests that the risk of exogenous testosterone replacement in patients with prostate cancer appears to be small, and the most prudent course is to follow such men with regular prostate specific antigen measurements and digital rectal examinations.

TL;DR: The largest cohort of patients undergoing 2-stage proximal hypospadias repair at a single institution is reviewed, with results indicating that complications and reoperation rates were approximately 50% in the setting of complex genital reconstruction.

TL;DR: Data highlight the association between pelvic fracture and genitourinary injuries in survivors of wartime combat, and suggest that a multidisciplinary approach be used to diagnose and treat these wounded veterans.

TL;DR: While certain patients with T1 micropapillary bladder cancer may respond to intravesical bacillus Calmette-Guérin, survival is improved in those who undergo early radical cystectomy.

TL;DR: The majority of small renal masses demonstrated considerable nuclear grade heterogeneity, and the greatest degree of heterogeneity and discordance was observed in high grade tumors.

TL;DR: It is suggested that fragment size larger than 4 mm after ureteroscopy is associated with significantly higher rates of stone growth, complications and the need for re-intervention.