Journal ArticleDOI
2.45-GHz microwave irradiation adversely affects reproductive function in male mouse, Mus musculus by inducing oxidative and nitrosative stress
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TLDR
It is observed that MW irradiation induced a significant decrease in sperm count and sperm viability along with the decrease in seminiferous tubule diameter and degeneration of seminiferously tubules, which suggest that chronic exposure to nonionizing MW radiation may lead to infertility via free radical species-mediated pathway.Abstract:
Electromagnetic radiations are reported to produce long-term and short-term biological effects, which are of great concern to human health due to increasing use of devices emitting EMR especially microwave (MW) radiation in our daily life. In view of the unavoidable use of MW emitting devices (microwaves oven, mobile phones, Wi-Fi, etc.) and their harmful effects on biological system, it was thought worthwhile to investigate the long-term effects of low-level MW irradiation on the reproductive function of male Swiss strain mice and its mechanism of action. Twelve-week-old mice were exposed to non-thermal low-level 2.45-GHz MW radiation (CW for 2 h/day for 30 days, power density = 0.029812 mW/cm(2) and SAR = 0.018 W/Kg). Sperm count and sperm viability test were done as well as vital organs were processed to study different stress parameters. Plasma was used for testosterone and testis for 3β HSD assay. Immunohistochemistry of 3β HSD and nitric oxide synthase (i-NOS) was also performed in testis. We observed that MW irradiation induced a significant decrease in sperm count and sperm viability along with the decrease in seminiferous tubule diameter and degeneration of seminiferous tubules. Reduction in testicular 3β HSD activity and plasma testosterone levels was also noted in the exposed group of mice. Increased expression of testicular i-NOS was observed in the MW-irradiated group of mice. Further, these adverse reproductive effects suggest that chronic exposure to nonionizing MW radiation may lead to infertility via free radical species-mediated pathway.read more
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Journal ArticleDOI
Manmade Electromagnetic Fields and Oxidative Stress-Biological Effects and Consequences for Health.
David Schuermann,Meike Mevissen +1 more
TL;DR: In this paper, the authors summarized key experimental findings on oxidative stress related to electromagnetic field exposure from animal and cell studies of the last decade and discussed in the context of molecular mechanisms and functionalities relevant to health such as neurological function, genome stability, immune response, and reproduction.
Journal ArticleDOI
2.45 GHz Microwave Radiation Impairs Learning and Spatial Memory via Oxidative/Nitrosative Stress Induced p53-Dependent/Independent Hippocampal Apoptosis: Molecular Basis and Underlying Mechanism
TL;DR: Exposure to CW MW radiation leads to oxidative/nitrosative stress induced p53-dependent/independent activation of hippocampal neuronal and nonneuronal apoptosis associated with spatial memory loss, and learning and spatial memory deficit which increases with the increased duration of MW exposure is correlated with a decrease in hippocampal subfield neuronal arborization and dendritic spines.
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Impact of 2.45 GHz microwave radiation on the testicular inflammatory pathway biomarkers in young rats: The role of gallic acid
TL;DR: Long term EMR exposure resulted in testicular physiopathology via oxidative damage and inflammation through mitotic activity, and the regenerative reaction increased in seminiferous tubules cells of the testes in EMR+GA group.
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Antioxidant and Antiapoptotic effect of aqueous extract of Pueraria tuberosa (Roxb. Ex Willd.) DC. On streptozotocin-induced diabetic nephropathy in rats
TL;DR: The findings suggest that PTY-2r exerted the nephroprotective potential against STZ induced DN rats via suppressing oxidative stress and apoptosis due to the presence of different bioactive compounds.
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From the Cover: 2.45-GHz Microwave Radiation Impairs Hippocampal Learning and Spatial Memory: Involvement of Local Stress Mechanism-Induced Suppression of iGluR/ERK/CREB Signaling.
TL;DR: 2.45 GHz MW radiation exposure induced local stress suppresses signaling mechanism(s) of hippocampal memory formation in adult male mice, leading to slow learning and significantly increased number of working and reference memory errors in radial maze task.
References
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Journal ArticleDOI
Preliminary Study on the Induction of Sperm Head Abnormalities in Mice, Mus musculus, Exposed to Radiofrequency Radiations from Global System for Mobile Communication Base Stations
TL;DR: The exposure of male mice to radiofrequency radiations from mobile phone (GSM) base stations at a workplace complex and residential quarters caused 39.78 and 46.03%, respectively, in sperm head abnormalities compared to 2.13% in control group.
Journal ArticleDOI
Fifty-gigahertz microwave exposure effect of radiations on rat brain.
TL;DR: It is concluded that these radiations can have a significant effect on the whole brain and DNA double-strand break and a significant decrease in GPx and SOD activity are causes in brain cells.
Journal ArticleDOI
In vitro effect of pulsed 900 MHz GSM radiation on mitochondrial membrane potential and motility of human spermatozoa.
Nadia Falzone,Carin Huyser,Francois Le R. Fourie,Tim Toivo,Dariusz Leszczynski,Daniel R. Franken +5 more
TL;DR: There was no effect of pulsed 900 MHz GSM radiation on mitochondrial membrane potential and the two kinematic parameters straight line velocity and beat‐cross frequency were significantly impaired over time after exposure at SAR 5.7 W/kg.
Journal ArticleDOI
Microwave exposure affecting reproductive system in male rats.
TL;DR: It is concluded that these radiations may have a significant effect on reproductive system of male rats, which may be an indication of male infertility.
Journal ArticleDOI
Glutathione peroxidase (GPX) activity in seminal plasma of healthy and infertile males.
Angela Giannattasio,M. De Rosa,R. Smeraglia,S. Zarrilli,A. Cimmino,B. Di Rosario,R. Ruggiero,A. Colao,G. Lombardi +8 more
TL;DR: The evaluation of GPX activity in human seminal plasma could be a new useful marker of gonadal function in men by using specific antibodies against plasmatic GPX (GPX3), and it is demonstrated that enzymatic activity, detected in the seminal plasma of both healthy and infertile males is GPX3.