Journal ArticleDOI
2.45-GHz microwave irradiation adversely affects reproductive function in male mouse, Mus musculus by inducing oxidative and nitrosative stress
Reads0
Chats0
TLDR
It is observed that MW irradiation induced a significant decrease in sperm count and sperm viability along with the decrease in seminiferous tubule diameter and degeneration of seminiferously tubules, which suggest that chronic exposure to nonionizing MW radiation may lead to infertility via free radical species-mediated pathway.Abstract:
Electromagnetic radiations are reported to produce long-term and short-term biological effects, which are of great concern to human health due to increasing use of devices emitting EMR especially microwave (MW) radiation in our daily life. In view of the unavoidable use of MW emitting devices (microwaves oven, mobile phones, Wi-Fi, etc.) and their harmful effects on biological system, it was thought worthwhile to investigate the long-term effects of low-level MW irradiation on the reproductive function of male Swiss strain mice and its mechanism of action. Twelve-week-old mice were exposed to non-thermal low-level 2.45-GHz MW radiation (CW for 2 h/day for 30 days, power density = 0.029812 mW/cm(2) and SAR = 0.018 W/Kg). Sperm count and sperm viability test were done as well as vital organs were processed to study different stress parameters. Plasma was used for testosterone and testis for 3β HSD assay. Immunohistochemistry of 3β HSD and nitric oxide synthase (i-NOS) was also performed in testis. We observed that MW irradiation induced a significant decrease in sperm count and sperm viability along with the decrease in seminiferous tubule diameter and degeneration of seminiferous tubules. Reduction in testicular 3β HSD activity and plasma testosterone levels was also noted in the exposed group of mice. Increased expression of testicular i-NOS was observed in the MW-irradiated group of mice. Further, these adverse reproductive effects suggest that chronic exposure to nonionizing MW radiation may lead to infertility via free radical species-mediated pathway.read more
Citations
More filters
Journal ArticleDOI
Manmade Electromagnetic Fields and Oxidative Stress-Biological Effects and Consequences for Health.
David Schuermann,Meike Mevissen +1 more
TL;DR: In this paper, the authors summarized key experimental findings on oxidative stress related to electromagnetic field exposure from animal and cell studies of the last decade and discussed in the context of molecular mechanisms and functionalities relevant to health such as neurological function, genome stability, immune response, and reproduction.
Journal ArticleDOI
2.45 GHz Microwave Radiation Impairs Learning and Spatial Memory via Oxidative/Nitrosative Stress Induced p53-Dependent/Independent Hippocampal Apoptosis: Molecular Basis and Underlying Mechanism
TL;DR: Exposure to CW MW radiation leads to oxidative/nitrosative stress induced p53-dependent/independent activation of hippocampal neuronal and nonneuronal apoptosis associated with spatial memory loss, and learning and spatial memory deficit which increases with the increased duration of MW exposure is correlated with a decrease in hippocampal subfield neuronal arborization and dendritic spines.
Journal ArticleDOI
Impact of 2.45 GHz microwave radiation on the testicular inflammatory pathway biomarkers in young rats: The role of gallic acid
TL;DR: Long term EMR exposure resulted in testicular physiopathology via oxidative damage and inflammation through mitotic activity, and the regenerative reaction increased in seminiferous tubules cells of the testes in EMR+GA group.
Journal ArticleDOI
Antioxidant and Antiapoptotic effect of aqueous extract of Pueraria tuberosa (Roxb. Ex Willd.) DC. On streptozotocin-induced diabetic nephropathy in rats
TL;DR: The findings suggest that PTY-2r exerted the nephroprotective potential against STZ induced DN rats via suppressing oxidative stress and apoptosis due to the presence of different bioactive compounds.
Journal ArticleDOI
From the Cover: 2.45-GHz Microwave Radiation Impairs Hippocampal Learning and Spatial Memory: Involvement of Local Stress Mechanism-Induced Suppression of iGluR/ERK/CREB Signaling.
TL;DR: 2.45 GHz MW radiation exposure induced local stress suppresses signaling mechanism(s) of hippocampal memory formation in adult male mice, leading to slow learning and significantly increased number of working and reference memory errors in radial maze task.
References
More filters
Journal ArticleDOI
Effects of 2·45 GHz Microwave Radiation and Heat on Mouse Spermatogenic Epithelium
R. D. Saunders,C I Kowalczuk +1 more
TL;DR: It is probable that a conscious animal is better able to regulate testicular temperature and hence adjust to higher dose-rates when exposed to microwave radiation, as well as the hypothesis that heat damage is the primary effect of microwave exposure.
Journal ArticleDOI
Influence of microwave exposure on fertility of male rats
TL;DR: It is concluded that there is a significant effect of microwave radiations on the reproductive pattern in male rats, which is a causative factor of male infertility.
Journal ArticleDOI
Effects of exposing chicken eggs to a cell phone in “call” position over the entire incubation period
TL;DR: Temperature, relative humidity and electromagnetic fields in the experimental chamber were permanently monitored over the entire experiment and a causal relationship between the intensity of the electric field and embryo mortality could not be established.
Journal ArticleDOI
Effect of Chronic Low-Intensity Microwave Radiation on Sperm Count, Sperm Morphology, and Testicular and Epididymal Tissues of Rats
Journal ArticleDOI
Sperm count and sperm abnormality in male mice after exposure to 2.45 GHz microwave radiation
TL;DR: Reduced male fertility correlates well with reduced pregnancy rate but less well with pre-implantation survival, and those which achieved fertilization cannot have possessed a dominant mutation which would result in the post-IMplantation death of the embryo.