Journal ArticleDOI
2.45-GHz microwave irradiation adversely affects reproductive function in male mouse, Mus musculus by inducing oxidative and nitrosative stress
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TLDR
It is observed that MW irradiation induced a significant decrease in sperm count and sperm viability along with the decrease in seminiferous tubule diameter and degeneration of seminiferously tubules, which suggest that chronic exposure to nonionizing MW radiation may lead to infertility via free radical species-mediated pathway.Abstract:
Electromagnetic radiations are reported to produce long-term and short-term biological effects, which are of great concern to human health due to increasing use of devices emitting EMR especially microwave (MW) radiation in our daily life. In view of the unavoidable use of MW emitting devices (microwaves oven, mobile phones, Wi-Fi, etc.) and their harmful effects on biological system, it was thought worthwhile to investigate the long-term effects of low-level MW irradiation on the reproductive function of male Swiss strain mice and its mechanism of action. Twelve-week-old mice were exposed to non-thermal low-level 2.45-GHz MW radiation (CW for 2 h/day for 30 days, power density = 0.029812 mW/cm(2) and SAR = 0.018 W/Kg). Sperm count and sperm viability test were done as well as vital organs were processed to study different stress parameters. Plasma was used for testosterone and testis for 3β HSD assay. Immunohistochemistry of 3β HSD and nitric oxide synthase (i-NOS) was also performed in testis. We observed that MW irradiation induced a significant decrease in sperm count and sperm viability along with the decrease in seminiferous tubule diameter and degeneration of seminiferous tubules. Reduction in testicular 3β HSD activity and plasma testosterone levels was also noted in the exposed group of mice. Increased expression of testicular i-NOS was observed in the MW-irradiated group of mice. Further, these adverse reproductive effects suggest that chronic exposure to nonionizing MW radiation may lead to infertility via free radical species-mediated pathway.read more
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Journal ArticleDOI
Manmade Electromagnetic Fields and Oxidative Stress-Biological Effects and Consequences for Health.
David Schuermann,Meike Mevissen +1 more
TL;DR: In this paper, the authors summarized key experimental findings on oxidative stress related to electromagnetic field exposure from animal and cell studies of the last decade and discussed in the context of molecular mechanisms and functionalities relevant to health such as neurological function, genome stability, immune response, and reproduction.
Journal ArticleDOI
2.45 GHz Microwave Radiation Impairs Learning and Spatial Memory via Oxidative/Nitrosative Stress Induced p53-Dependent/Independent Hippocampal Apoptosis: Molecular Basis and Underlying Mechanism
TL;DR: Exposure to CW MW radiation leads to oxidative/nitrosative stress induced p53-dependent/independent activation of hippocampal neuronal and nonneuronal apoptosis associated with spatial memory loss, and learning and spatial memory deficit which increases with the increased duration of MW exposure is correlated with a decrease in hippocampal subfield neuronal arborization and dendritic spines.
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Impact of 2.45 GHz microwave radiation on the testicular inflammatory pathway biomarkers in young rats: The role of gallic acid
TL;DR: Long term EMR exposure resulted in testicular physiopathology via oxidative damage and inflammation through mitotic activity, and the regenerative reaction increased in seminiferous tubules cells of the testes in EMR+GA group.
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Antioxidant and Antiapoptotic effect of aqueous extract of Pueraria tuberosa (Roxb. Ex Willd.) DC. On streptozotocin-induced diabetic nephropathy in rats
TL;DR: The findings suggest that PTY-2r exerted the nephroprotective potential against STZ induced DN rats via suppressing oxidative stress and apoptosis due to the presence of different bioactive compounds.
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From the Cover: 2.45-GHz Microwave Radiation Impairs Hippocampal Learning and Spatial Memory: Involvement of Local Stress Mechanism-Induced Suppression of iGluR/ERK/CREB Signaling.
TL;DR: 2.45 GHz MW radiation exposure induced local stress suppresses signaling mechanism(s) of hippocampal memory formation in adult male mice, leading to slow learning and significantly increased number of working and reference memory errors in radial maze task.
References
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Role of antioxidants in treatment of male infertility: an overview of the literature
TL;DR: It was found that although many clinical trials have demonstrated the beneficial effects of antioxidants in selected cases of male infertility, some studies failed to demonstrate the same benefit, and conclusive evidence on the benefit of antioxidants as a treatment modality for patients with male infertility is still needed.
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Differential incorporation of fatty acids into and peroxidative loss of fatty acids from phospholipids of human spermatozoa
Juan G. Alvarez,Bayard T. Storey +1 more
TL;DR: Intact human sperm incorporated radiolabelled fatty acids into membrane phospholipids when incubated in medium containing bovine serum albumin as a fatty acid carrier, indicating that aospholipase A2 may act in peroxidative defense by excising a hydroperoxy acyl group from phospholIPid and providing the hydro peroxy fatty acid product as substrate to glutathione peroxIDase.
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Effect of cell phone usage on semen analysis in men attending infertility clinic: an observational study
TL;DR: Use of cell phones decrease the semen quality in men by decreasing the sperm count, motility, viability, and normal morphology.
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Analysis of the impact of intracellular reactive oxygen species generation on the structural and functional integrity of human spermatozoa: lipid peroxidation, DNA fragmentation and effectiveness of antioxidants.
TL;DR: For cases involving excessive intracellular ROS generation, albumin appears to be an important means of neutralizing lipid peroxide-mediated damage to the sperm plasma membrane and DNA.
Journal ArticleDOI
Effects of radiofrequency electromagnetic waves (RF-EMW) from cellular phones on human ejaculated semen: an in vitro pilot study
Ashok Agarwal,Nisarg R Desai,Kartikeya Makker,Alex C. Varghese,Rand Mouradi,Edmund Sabanegh,Rakesh Sharma +6 more
TL;DR: Radiofrequency electromagnetic waves emitted from cell phones may lead to oxidative stress in human semen and speculate that keeping the cell phone in a trouser pocket in talk mode may negatively affect spermatozoa and impair male fertility.