Journal ArticleDOI
64Cu-labeled PEGylated polyethylenimine for cell trafficking and tumor imaging.
TLDR
64Cu-labeled polyethylenimine can be used for both cell trafficking and tumor imaging and PEGylation reduces the toxicity of 64Cu-PEI and improves the tumor imaging ability.Abstract:
Purpose
In this study, we exploited the potential of 64Cu-labeled polyethylenimine (PEI) for cell trafficking and tumor imaging as compared to copper-64-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (64Cu-PTSM).read more
Citations
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Journal ArticleDOI
Radiopharmaceutical chemistry for positron emission tomography.
Zibo Li,Peter S. Conti +1 more
TL;DR: An overview of the most common chemical approaches for the synthesis of PET-labeled molecules is provided and the most recent developments and trends are highlighted.
Journal ArticleDOI
Red Blood Cell‐Facilitated Photodynamic Therapy for Cancer Treatment
Wei Tang,Zipeng Zhen,Mengzhe Wang,Hui Wang,Yen-Jun Chuang,Weizhong Zhang,Geoffrey D. Wang,Trever Todd,Taku Cowger,Hongmin Chen,Lin Liu,Zibo Li,Jin Xie +12 more
TL;DR: A new technology called red blood cell (RBC)‐facilitated PDT, or RBC‐PDT, is introduced that can potentially solve the issue of low O2 levels in tumors and is expected to find wide applications in modern oncology.
Journal ArticleDOI
Non-invasive cell tracking in cancer and cancer therapy.
TL;DR: Non-invasive tracking of immune and stem cells were primarily intended for (potential) cancer therapy applications while tracking of cancer cells could further the understanding of cancer development and tumor metastasis.
Journal ArticleDOI
[89Zr]Oxinate4 for long-term in vivo cell tracking by positron emission tomography
Putthiporn Charoenphun,Levente K. Meszaros,Krisanat Chuamsaamarkkee,Ehsan Sharif-Paghaleh,James R. Ballinger,Trevor J. Ferris,Michael J. Went,Gregory E. D. Mullen,Philip J. Blower,Philip J. Blower +9 more
TL;DR: [89Zr]Oxinate4 offers a potential solution to the emerging need for a long half-life PET tracer for cell tracking in vivo and deserves further evaluation of its effects on survival and behaviour of different cell types.
Journal ArticleDOI
Imaging of T-cells and their responses during anti-cancer immunotherapy.
Massis Krekorian,Gilbert O. Fruhwirth,Mangala Srinivas,Carl G. Figdor,Sandra Heskamp,Timothy H. Witney,Erik H.J.G. Aarntzen +6 more
TL;DR: This review comprises a comprehensive analysis of the in vivo imaging technologies that allow the characterisation of T-cell responses induced by anti-cancer immunotherapy, with emphasis on technologies that are clinically available or have high translational potential.
References
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Journal ArticleDOI
Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes
TL;DR: The results provide direct support for the proton sponge hypothesis and thus a rational basis for the design of improved non-viral vectors for gene delivery.
Journal ArticleDOI
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
Raymond M. Schiffelers,Aslam M. Ansari,Jun Xu,Qin Zhou,Qingquan Tang,Gert Storm,Grietje Molema,Patrick Y. Lu,Puthupparampil V. Scaria,Martin C. Woodle +9 more
TL;DR: The results suggest achievement of two levels of targeting: tumor tissue selective delivery via the nanoparticle ligand and gene pathway selectivity via the siRNA oligonucleotide, opening the door for better targeted therapeutics with both tissue and gene selectivity, also to improve targeted therapies with less than ideal therapeutic targets.
Journal ArticleDOI
Polyethylenimine-graft-poly(ethylene glycol) copolymers: influence of copolymer block structure on DNA complexation and biological activities as gene delivery system.
Holger Petersen,Petra M. Fechner,Alison L. Martin,Klaus Kunath,Snjezana Stolnik,Clive J. Roberts,Dagmar Fischer,Martyn C. Davies,Thomas Kissel +8 more
TL;DR: The degree of PEGylation and the MW of P EG were found to strongly influence DNA condensation of PEI and therefore also affect the biological activity of the PEI-g-PEG/DNA complexes, providing a basis for the rational design of block copolymer gene delivery systems.
Journal ArticleDOI
RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature
TL;DR: This review will summarize the structural requirements for RGD-peptides andRGD-mimetics as ligands for alphavbeta3 and show how they have been introduced in the various types of constructs by chemical and recombinant techniques.
Journal ArticleDOI
Copper radionuclides and radiopharmaceuticals in nuclear medicine
TL;DR: The chemistry, radiochemistry, radiobiology, and radiopharmacology of radiopharmaceuticals containing copper radionuclides are reviewed and are likely to be applied more fully in the future.
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