Journal ArticleDOI
Radiopharmaceutical chemistry for positron emission tomography.
Zibo Li,Peter S. Conti +1 more
TLDR
An overview of the most common chemical approaches for the synthesis of PET-labeled molecules is provided and the most recent developments and trends are highlighted.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2010-08-30. It has received 217 citations till now. The article focuses on the topics: Molecular imaging & Positron emission tomography.read more
Citations
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Journal ArticleDOI
Applications of Fluorine in Medicinal Chemistry
TL;DR: The effects of the strategic incorporation of fluorine in drug molecules and applications in positron emission tomography are provided, as well as new synthetic methodologies that allow more facile access to a wide range of fluorinated compounds.
Journal ArticleDOI
Matching chelators to radiometals for radiopharmaceuticals.
TL;DR: This article is a guide for selecting the optimal match between chelator and radiometal for use in these systems, and a large selection of the most common and most promising chelators are evaluated and discussed for their potential use with a variety of radiometals.
Journal ArticleDOI
Chemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia
Jianan Liu,Wenbo Bu,Jianlin Shi +2 more
TL;DR: This review will provide an overview of the reports published to date on the imaging and therapy of hypoxic tumors, and present the design concepts and engineering of various hypoxia-responsive probes that can be applied to imageHypoxia noninvasively, in an order of fluorescent imaging, positron emission tomography, magnetic resonance imaging, and photoacoustic imaging.
Journal ArticleDOI
18F labeling of arenes.
TL;DR: This Minireview focuses on recent developments in the ( 18)F-labeling of aromatic substrates in the field of (18) F-radiochemistry.
Journal ArticleDOI
Click Chemistry and Radiochemistry: The First 10 Years
TL;DR: A broad overview of the first 10 years of research at the intersection of click chemistry and radiochemistry is provided, inspiring synthetic chemists and radiochemists alike to harness click chemistry in even more innovative and ambitious ways as they embark upon the second decade of this fruitful collaboration.
References
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Journal ArticleDOI
Rapid prototyping of microfluidic systems in poly(dimethylsiloxane)
TL;DR: A procedure that makes it possible to design and fabricate microfluidic systems in an elastomeric material poly(dimethylsiloxane) (PDMS) in less than 24 h by fabricating a miniaturized capillary electrophoresis system is described.
Journal Article
Efficient Stereospecific Synthesis of No-Carrier-Added 2-[18F]-Fluoro-2-Deoxy-D-Glucose Using Aminopolyether Supported Nucleophilic Substitution
TL;DR: An aminopolyether mediated synthesis of fluorine-18 (18F) 2-fluoro-2-deoxy-D-glucose (FDG) has been developed and gives epimerically pure 2-18FDG with an uncorrected radiochemical yield of a maximum 50% in a synthesis time of approximately 50 min from EOB.
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Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity.
TL;DR: A bioorthogonal reaction that proceeds with unusually fast reaction rates without need for catalysis: the cycloaddition of s-tetrazine and trans-cyclooctene derivatives, which enables protein modification at low concentration.
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Near-infrared fluorescence: application to in vivo molecular imaging
TL;DR: Recent advances in understanding of factors that define the effectiveness of imaging agents in vivo as they pertain to the application of optical reporters for in vivo imaging are discussed in this review.
Journal ArticleDOI
Synthesis of 11C, 18F, 15O, and 13N Radiolabels for Positron Emission Tomography
TL;DR: This Review highlights key aspects of the synthesis of PET radiotracers with the short-lived positron-emitting radionuclides (11)C, (18)F, (15)O, and (13)N, with emphasis on the most recent strategies.