A combined role for low vitamin D and low albumin circulating levels as strong predictors of worse outcome in COVID-19 patients
Gianfranco Sanson,Amedeo De Nicolò,Verena Zerbato,Ludovica Segat,Raffaella Koncan,Stefano Di Bella,Jessica Cusato,Alessandra di Masi,Andrea Palermo,Pietro Caironi,Pierlanfranco D'Agaro,Roberto Luzzati,Antonio D'Avolio +12 more
TLDR
In this article , a prospective observational study on adult patients hospitalized for SARS-CoV-2 pneumonia (March-September 2020) was conducted, where the combined role of vitamin D and albumin serum levels as predictors of COVID-19 disease progression was assessed.Abstract:
We aimed to assess the combined role of vitamin D and albumin serum levels as predictors of COVID-19 disease progression.We conducted a prospective observational study on adult patients hospitalized for SARS-CoV-2 pneumonia (March-September 2020). Vitamin D and albumin serum levels were measured on admission. These variables were categorized in albumin < 3.5 or ≥ 3.5 g/dL and vitamin D < 30 ng/mL or ≥ 30 ng/mL. We excluded patients with known bone diseases, renal failure, hypercalcemia and/or treated with antiepileptic drugs and steroids, and patients who received previous vitamin D supplementation. A composite outcome including any ventilatory support, PaO2/FiO2 ratio, and 60-day mortality was defined.Sixty-nine patients were enrolled, of whom 50% received non-invasive (NIV) or invasive mechanical ventilation (IMV), 10% died, whereas 89% and 66% presented low albumin and low vitamin D serum levels, respectively. No correlation between vitamin D and albumin levels was found. In multivariable logistic regression analyses adjusted for sex and age-corrected comorbidities, patients having albumin < 3.5 g/dL and vitamin D < 30 ng/mL showed a significant increased risk for all study outcomes, namely NIV/IMV (OR 3.815; 95% CI 1.122-12.966; p = 0.032), NIV/IMV or death (OR 3.173; 95% CI 1.002-10.043; p = 0.049) and PaO2/FIO2 ≤ 100 (OR 3.410; 95% CI 1.138-10.219; p = 0.029).The measurement of both vitamin D and serum albumin levels on COVID-19 patients' admission, and their combined evaluation, provides a simple prognostic tool that could be employed to guide prompt clinical decisions. read more
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The Association Between FT3 With the Outcome and Inflammation/Coagulopathy/Fibrinolysis of COVID-19
TL;DR: Low FT3 had a significant predictive value on the prognosis of COVID-19 patients, and FT3 was significantly related with clinic parameters of inflammation/coagulopathy/fibrinolysis.
Journal ArticleDOI
C-Reactive Protein and Serum Albumin Ratio: A Feasible Prognostic Marker in Hospitalized Patients with COVID-19
Vicente Giner-Galvañ,Francisco José Pomares-Gómez,J Martínez Quesada,Manuel Rubio-Rivas,Javier Tejada-Montes,Jesús Baltasar-Corral,M. Taboada-Martínez,Blanca Sánchez-Mesa,Francisco Arnalich-Fernández,Esther Del Corral-Beamonte,Almudena López-Sampalo,Paula M. Pesqueira-Fontán,Mar Fernández-Garcés,Ricardo Gómez-Huelgas,José Manuel Ramos-Rincón,On Behalf Of The Semi-Covid-Network +15 more
TL;DR: SA and CRP are good independent predictors of patients hospitalized with COVID-19 and for the CRP/SA ratio value, 25 is the cutoff for poor clinical course.
Journal ArticleDOI
Possible Impact of Vitamin D Status and Supplementation on SARS-CoV-2 Infection Risk and COVID-19 Symptoms in a Cohort of Patients with Inflammatory Bowel Disease
Amedeo De Nicolò,Jessica Cusato,Cristina Bezzio,Simone Saibeni,Marta Vernero,M. Disabato,Gian Paolo Caviglia,Alice Ianniello,Alessandra Manca,Antonio D'Avolio,Davide Giuseppe Ribaldone +10 more
TL;DR: In this article , a cohort of 106 adults affected by IBD was prospectively enrolled, during the second wave of the pandemic in Italy, and VD plasma levels, demographic and clinical characteristics were tested for a correlation/an association with the risk of infection with SARS-CoV-2 in the study period (anti-spike IgG positivity) and the severity of COVID-19 symptoms.
Journal ArticleDOI
Pulmonary fibrosis in patients with COVID-19: A retrospective study
Yanjun Zhong,Yasuhiko Yamamoto +1 more
TL;DR: Wang et al. as mentioned in this paper found that pulmonary fibrosis (PF) was significantly correlated with coagulation indexes prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (Fib) and fibrinolysis index D-Dimer at some phases.
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TL;DR: Considering that vitamin D deficiency is very common in all age groups and that few foods contain vitamin D, the Task Force recommended supplementation at suggested daily intake and tolerable upper limit levels, depending on age and clinical circumstances.
Journal Article
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TL;DR: The Task Force as discussed by the authors provided guidelines to clinicians for the evaluation, treatment, and prevention of vitamin D deficiency with an emphasis on the care of patients who are at risk for deficiency, based on systematic reviews of evidence and discussions during several conference calls and e-mail communications.
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The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know
A. Catharine Ross,JoAnn E. Manson,Steven A. Abrams,John F. Aloia,John F. Aloia,Patsy M. Brannon,Steven K. Clinton,Ramon Durazo-Arvizu,J. Christopher Gallagher,Richard L. Gallo,Glenville Jones,Christopher S. Kovacs,Susan Taylor Mayne,Clifford J. Rosen,Sue A. Shapses +14 more
TL;DR: The Committee concluded that the prevalence of vitamin D inadequacy in North America has been overestimated and urgent research and clinical priorities were identified, including reassessment of laboratory ranges for 25-hydroxyvitamin D, to avoid problems of both undertreatment and overtreatment.