Book ChapterDOI
A Common Molecular Switch for H 2 S to Regulate Multiple Protein Targets
Bei-Bei Tao,Yi-Chun Zhu +1 more
TLDR
In this article, two main theories of hydrogen sulfide's working mechanism are discussed and compared, and the authors discuss which one is the more effective or direct mechanism for H2S and what is the relationship between them.Abstract:
Hydrogen sulfide, a small molecule, produced by endogenous enzymes, such as CTH, CBS, and MPST using L-cysteine as substrates, has been reported to have numerous protective effects. However, the key problem that the target of H2S and how it can affect the structure and activity of biological molecules is still unknown. Till now, there are two main theories of its working mechanism. One is that H2S can modify the free thiol in cysteine to produce the persulfide state of the thiol and the sulfhydration of cysteine can significantly change the structure and activity of target proteins. The other theory is that H2S, as an antioxidant molecule, can directly break the disulfide bond in target proteins, and the persulfide state of thiol can be an intermediate product during the reaction. Both phenomena exit for no doubt since they are both supported by large amounts of experiments. Here, we will summarize both theories and try to discuss which one is the more effective or direct mechanism for H2S and what is the relationship between them. Therefore, we will discover more protein targets of H2S with the mechanism and understand more about the effect of this small molecule.read more
Citations
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Journal ArticleDOI
H2S: A new gas with potential biotechnological applications in postharvest fruit and vegetable storage: An overview
TL;DR: In this article , a review mainly summarizes the biochemistry of hydrogen sulfide, and the latest information on the role of H2S in the senescence, disease resistance, and postharvest stages of fruits and vegetables, providing a theoretical basis for the application and popularization of h2S.
References
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Journal ArticleDOI
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Journal ArticleDOI
The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener
TL;DR: It is demonstrated that H2S is an important endogenous vasoactive factor and the first identified gaseous opener of KATP channels in vascular SMCs and production from vascular tissues was enhanced by nitric oxide.
Journal ArticleDOI
Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
TL;DR: The important life-supporting role of hydrogen sulfide (H(2)S) has evolved from bacteria to plants, invertebrates, vertebrate, vertebrates, and finally to mammals, but over the centuries it had only been known for its toxicity and environmental hazard.
Journal ArticleDOI
An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
TL;DR: It is found that the EGFR kinase domain can be activated by increasing its local concentration or by mutating a leucine in the activation loop, which suggests that the Kinase domain is intrinsically autoinhibited, and an intermolecular interaction promotes its activation.