A Data-Validated Host-Parasite Model for Infectious Disease Outbreaks
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TLDR
A model to describe host-parasite dynamics of the well-studied guppy-Gyrodactylus turnbulli system is designed, using experimental data to estimate parameters and validate it, and the basic reproduction number is estimated, for this system.Abstract:
The use of model experimental systems and mathematical models is important to further understanding of infectious disease dynamics and strategize disease mitigation. Gyrodactylids are helminth ectoparasites of teleost fish which have many dynamical characteristics of microparasites but offer the advantage that they can be quantified and tracked over time, allowing further insight into within-host and epidemic dynamics. In this paper, we design a model to describe host-parasite dynamics of the well-studied guppy-Gyrodactylus turnbulli system, using experimental data to estimate parameters and validate it. We estimate the basic reproduction number (R_0), for this system. Sensitivity analysis reveals that parasite growth rate, and the rate at which the guppy mounts an immune response have the greatest impact on outbreak peak and timing both for initial outbreaks and on longer time scales. These findings highlight guppy population resistance and parasite virulence as key factors in disease control, and future work should focus on incorporating heterogeneity in host resistance into disease models and extrapolating to other host-parasite systems.read more
Citations
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Population growth of <i>Gyrodactylus kobayashii</i> in goldfish (<i>Carassius auratus</i>) associated with host density
TL;DR: In this paper , the authors used the goldfish (Carassius auratus)-Gyrodactylus kobayashii model to investigate the effects of host density on population growth of gyrodactylids.
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A generalized distributed delay model of COVID-19: An endemic model with immunity waning.
TL;DR: In this article , the authors developed and analyzed an endemic model of COVID-19 that incorporates the waning of both vaccine-and infection-induced immunities using distributed delay equations and derived a nonlinear ODE system from the distributed delay model.
Journal ArticleDOI
Transmission dynamics of ectoparasitic gyrodactylids (Platyhelminthes, Monogenea): An integrative review
TL;DR: The transmission dynamics of Gyrodactylus species, which are monogenean ectoparasites of teleost fishes and a prominent model for studies of parasite transmission, are reviewed.
Journal ArticleDOI
Transmission dynamics of ectoparasitic gyrodactylids (Platyhelminthes, Monogenea): An integrative review
TL;DR: In this article , the authors review the transmission dynamics of Gyrodactylus species, which are monogenean ectoparasites of teleost fishes and a prominent model for studies of parasite transmission.
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Putative chemical cue from <i>Gyrodactylus-</i>infected guppies subtly alters behaviour but prior exposure decreases parasite intensity
TL;DR: In this paper , exposure to chemical cues from Gyrodactylus turnbulli-infected guppies at various times post-infection resulted in altered behaviour of uninfected conspecifics, and if prior exposure to this putative infection cue reduced transmission.
References
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