V
Vitaly V. Ganusov
Researcher at University of Tennessee
Publications - 112
Citations - 4689
Vitaly V. Ganusov is an academic researcher from University of Tennessee. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 34, co-authored 102 publications receiving 4158 citations. Previous affiliations of Vitaly V. Ganusov include Utrecht University & Emory University.
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Journal ArticleDOI
The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection
Nilu Goonetilleke,Michael K. P. Liu,Jesus F. Salazar-Gonzalez,Guido Ferrari,Elena E. Giorgi,Vitaly V. Ganusov,Brandon F. Keele,Gerald H. Learn,Emma L. Turnbull,Maria G. Salazar,Kent J. Weinhold,Stephen Moore,Norman L. Letvin,Barton F. Haynes,Myron S. Cohen,Peter T. Hraber,Tanmoy Bhattacharya,Tanmoy Bhattacharya,Persephone Borrow,Alan S. Perelson,Beatrice H. Hahn,George M. Shaw,Bette T. Korber,Bette T. Korber,Andrew J. McMichael +24 more
TL;DR: Kinetic analysis and mathematical modeling of virus immune escape showed that the contribution of CD8 T cell–mediated killing of productively infected cells was earlier and much greater than previously recognized and that it contributed to the initial decline of plasma virus in acute infection.
Journal ArticleDOI
Transmission of Single HIV-1 Genomes and Dynamics of Early Immune Escape Revealed by Ultra-Deep Sequencing
Will Fischer,Vitaly V. Ganusov,Vitaly V. Ganusov,Elena E. Giorgi,Elena E. Giorgi,Peter T. Hraber,Brandon F. Keele,Thomas Leitner,Cliff Han,Cheryl D. Gleasner,Lance D. Green,Chien-Chi Lo,Ambarish Nag,Timothy C. Wallstrom,Shuyi Wang,Andrew J. McMichael,Barton F. Haynes,Beatrice H. Hahn,Alan S. Perelson,Persephone Borrow,George M. Shaw,Tanmoy Bhattacharya,Tanmoy Bhattacharya,Bette T. Korber,Bette T. Korber +24 more
TL;DR: Traces of immune escape were observed in the earliest samples, suggesting that immune pressure is present and effective earlier than previously reported; quantifying the loss rate of the founder virus suggests a direct role for CD8 T-lymphocyte responses in viral containment after peak viremia.
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CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease.
Shunsuke Sakai,Keith D. Kauffman,Michelle A. Sallin,Arlene H. Sharpe,Howard A. Young,Vitaly V. Ganusov,Daniel L. Barber +6 more
TL;DR: The primary role for T cell-derived IFN-γ in Mtb infection is at extra-pulmonary sites, and the host-protective subset of CD4 T cells requires negative regulation of IFN–γ production by PD-1 to prevent lethal immune-mediated pathology.
Journal ArticleDOI
The role of models in understanding CD8+ T-cell memory.
TL;DR: This work outlines how mathematical models have contributed to the understanding of CD8+ T-cell memory and quantitatively describes and further understanding of both the generation of memory after infection with a pathogen and the maintenance of this memory throughout the life of an individual.
Journal ArticleDOI
Vertical T cell immunodominance and epitope entropy determine HIV-1 escape
Michael K. P. Liu,Natalie Hawkins,Adam J. Ritchie,Vitaly V. Ganusov,Victoria E. Whale,Simon Brackenridge,Hui Li,Jeffrey W. Pavlicek,Fangping Cai,Melissa Rose-Abrahams,Florette K. Treurnicht,Peter T. Hraber,Catherine Riou,Clive M. Gray,Guido Ferrari,Rachel Tanner,Li Hua Ping,Jeffrey A. Anderson,Ronald Swanstrom,Myron S. Cohen,Salim S. Abdool Karim,Barton F. Haynes,Persephone Borrow,Alan S. Perelson,Alan S. Perelson,George M. Shaw,Beatrice H. Hahn,Carolyn Williamson,Bette T. Korber,Bette T. Korber,Feng Gao,Steve Self,Andrew J. McMichael,Nilu Goonetilleke +33 more
TL;DR: It is explained how CD8+ T cells can exert significant and sustained HIV-1 pressure even when escape is very slow and that within an individual, the impacts of other T cell factors on HIV- 1 escape should be considered in the context of immunodominance.