A Decade of DTI in Traumatic Brain Injury: 10 Years and 100 Articles Later
TLDR
In this paper, the authors present a quantitative literature review of the use of DTI to detect brain abnormalities in patients with Traumatic Brain Injury (TBI) and conclude that DTI is well suited to the interrogation of white matter microstructure, the most important location of pathology in TBI.Abstract:
SUMMARY: The past decade has seen an increase in the number of articles reporting the use of DTI to detect brain abnormalities in patients with traumatic brain injury. DTI is well-suited to the interrogation of white matter microstructure, the most important location of pathology in TBI. Additionally, studies in animal models have demonstrated the correlation of DTI findings and TBI pathology. One hundred articles met the inclusion criteria for this quantitative literature review. Despite significant variability in sample characteristics, technical aspects of imaging, and analysis approaches, the consensus is that DTI effectively differentiates patients with TBI and controls, regardless of the severity and timeframe following injury. Furthermore, many have established a relationship between DTI measures and TBI outcomes. However, the heterogeneity of specific outcome measures used limits interpretation of the literature. Similarly, few longitudinal studies have been performed, limiting inferences regarding the long-term predictive utility of DTI. Larger longitudinal studies, using standardized imaging, analysis approaches, and outcome measures will help realize the promise of DTI as a prognostic tool in the care of patients with TBI. ABBREVIATIONS: FA fractional anisotropy; GCS Glasgow Coma Scale; MD mean diffusivity; TAI traumatic axonal injury; TBI traumatic brain injury; TBSS tract-based spatial statisticsread more
Citations
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Journal ArticleDOI
Traumatic brain injuries.
Kaj Blennow,David L. Brody,Patrick M. Kochanek,Harvey S. Levin,Ann C. McKee,Gerard M. Ribbers,Kristine Yaffe,Henrik Zetterberg,Henrik Zetterberg,Henrik Zetterberg +9 more
TL;DR: MRI techniques and blood tests for axonal proteins to identify and grade axonal injury, in addition to PET for tau pathology, show promise as tools to explore CTE pathophysiology in longitudinal clinical studies, and might be developed into diagnostic tools for CTE.
Journal ArticleDOI
White matter involvement after TBI: Clues to axon and myelin repair capacity.
TL;DR: Distinguishing the complex white matter changes associated with axons and myelin is necessary for interpreting advanced neuroimaging approaches and for identifying a broader range of therapeutic opportunities to improve outcome after TBI.
Journal ArticleDOI
Aging of cerebral white matter.
Huan Liu,Yuanyuan Yang,Yuguo Xia,Wen Zhu,Rehana K. Leak,Zhishuo Wei,Jianyi Wang,Xiaoming Hu,Xiaoming Hu +8 more
TL;DR: The structural and functional alterations of WM in natural aging are summarized and how age-related WM changes influence the progression of various brain disorders, including ischemic and hemorrhagic stroke, TBI, Alzheimer's disease, and Parkinson's disease are discussed.
Journal ArticleDOI
Traumatic Brain Injury as a Disorder of Brain Connectivity.
TL;DR: TBI is associated with altered structural and functional connectivity, characterized by decreased integrity of white matter pathways and imbalance and inefficiency of functional networks, which are often associated with neurocognitive dysfunction and poor functional outcomes.
Journal ArticleDOI
Neuroimaging biomarkers in mild traumatic brain injury (mTBI).
TL;DR: A thesis for the select use of sensitive neuroimaging methods as potential biomarkers of brain injury recognizing that the majority of individuals who sustain an mTBI recover without Neuroimaging signs or neuropsychological sequelae detected with methods currently applied.
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