Journal ArticleDOI
A Facile Synthesis of Bromo-Substituted Benzofuran Containing Thiazolidinone Nucleus Bridged with Quinoline Derivatives: Potent Analgesic and Antimicrobial Agents
TLDR
In this paper, 5-bromo-2-acetyl benzofuran with hydrazine followed by condensation of the resulting hydrazone with different quinoline derivatives gave the corresponding Schiff bases.Abstract:
Treatment of 5-bromo-2-acetyl benzofuran with hydrazine followed by condensation of the resulting hydrazone with different quinoline derivatives gave the corresponding Schiff bases. Reaction of these Schiff bases with thioacetic acid furnished the target thiazolidinone molecule. Some of the newly synthesized compounds show promising analgesic and antimicrobial activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.read more
Citations
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Journal ArticleDOI
Recent developments and biological activities of thiazolidinone derivatives: A review
TL;DR: This review aims to review the work reported on various biological activities of thiazolidinone derivatives from year 2000 to the beginning of 2011 and presents data for active compounds, some of which have passed the preclinical testing stage.
Journal ArticleDOI
Benzofuran: an emerging scaffold for antimicrobial agents
Asha Hiremathad,Asha Hiremathad,Mahadeo R. Patil,K. R. Chethana,Karam Chand,M. Amélia Santos,Rangappa S. Keri +6 more
TL;DR: This study systematically provides a comprehensive report on current developments in benzofuran-based compounds as antimicrobial agents and is helpful for the researchers working on a substitution pattern around the nucleus, with an aim to help medicinal chemists to develop structure activity relationships (SAR) on these derivatives as antimacterial drugs.
Journal ArticleDOI
A review on antioxidant potential of bioactive heterocycle benzofuran: Natural and synthetic derivatives
Karam Chand,Rajeshwari,Asha Hiremathad,Mahak Singh,M. Amélia Santos,Rangappa S. Keri,Rangappa S. Keri +6 more
TL;DR: This study systematically provides a comprehensive report on current developments in benzofuran-based compounds as antioxidant agents and is helpful for the researchers working on a substitution pattern around the nucleus, with an aim to help medicinal chemists to develop structure activity relationships (SAR) on these derivatives as antioxidant drugs.
Journal ArticleDOI
Microwave assisted synthesis and antimicrobial evaluation of new fused pyran derivatives bearing 2-morpholinoquinoline nucleus.
TL;DR: A new series of fused pyran derivatives 5a-x bearing 2-morpholinoquinoline nucleus has been synthesized under microwave irradiation by a reaction of 2- Morpholinoquoline-3-carbaldehyde 2a-c, malononitrile 3 and compounds 4a-h in presence of NaOH as basic catalyst.
Journal ArticleDOI
An efficient domino reaction in ionic liquid: synthesis and biological evaluation of some pyrano- and thiopyrano-fused heterocycles.
TL;DR: An improved domino/Knoevenagel-hetero-Diels-Alder reaction of two new aldehyde substrates; 7-olefinoxy-coumarin-8-carbaldehyde and 2-alkensulfanyl-quinoline-3- carbaldehyde, with pyrazolones was studied in ionic liquid triethylammonium acetate (TEAA).
References
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Book
Comprehensive Heterocyclic Chemistry II
TL;DR: In this article, the CHEC III is organized in 15 volumes and closely follows the organization used in the previous edition: Volumes 1 and 2: Cover respectively three and four-membered heterocycles, together with all fused systems containing a three- or four-measured heterocyclic ring.
Journal ArticleDOI
Synthesis and structure-affinity-activity relationships of novel benzofuran derivatives as MT(2) melatonin receptor selective ligands.
Wallez Valerie,Sophie Durieux-Poissonnier,Philippe Chavatte,Jean A. Boutin,Valérie Audinot,Jean-Paul Nicolas,Caroline Bennejean,Philippe Delagrange,Pierre Renard,Daniel Lesieur +9 more
TL;DR: The most selective compounds 10c and 19 show affinity ratios of 123 and 192, respectively, and bind to the MT(2) subtype similarly to melatonin itself (0.1 nM).
Journal ArticleDOI
Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity.
Christophe Benard,Fatima Zouhiri,Marie Normand-Bayle,Michèle Danet,Didier Desmaële,Hervé Leh,Jean-François Mouscadet,Gladys Mbemba,Claire-Marie Thomas,Sabine Bonnenfant,Marc Le Bret,Jean d'Angelo +11 more
TL;DR: A novel series of HIV-1 integrase inhibitors was synthesized and tested in both in vitro and ex vivo assays and amide derivatives are the most promising ones and could serve as leads for further developments.
Journal ArticleDOI
Synthesis of 2-Substituted Benzofurans and Indoles Using Functionalized Titanium Benzylidene Reagents on Solid Phase
Calum Macleod,Gordon J. McKiernan,Emma J. Guthrie,Louis J. Farrugia,Dieter Hamprecht,Jackie Macritchie,Richard C. Hartley +6 more
TL;DR: Titanium(IV) benzylidenes bearing a masked oxygen or nitrogen nucleophile in the ortho position were generated from thioacetals, using low-valent titanocene complex, Cp2Ti[P(OEt)3]2.
Journal ArticleDOI
Deprotonation of benzylic ethers using a hindered phosphazene base. A synthesis of benzofurans from ortho-substituted benzaldehydes.
TL;DR: The hindered nonionic phosphazene base P(4)-t-Bu efficiently deprotonates o-arylmethoxy benzaldehydes, leading to a direct synthesis of benzofurans.