Journal ArticleDOI
A functional myeloperoxidase polymorphic variant is associated with coronary artery disease in French-Canadians
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TLDR
The findings suggest that the -463 G/A polymorphism of the MPO gene influences the risk of CAD, and this effect may be mediated by the effect of this polymorphism on the transcription level of theMPO gene.About:
This article is published in American Heart Journal.The article was published on 2001-08-01. It has received 208 citations till now. The article focuses on the topics: Myeloperoxidase & Coronary artery disease.read more
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Journal ArticleDOI
Association between myeloperoxidase levels and risk of coronary artery disease.
Renliang Zhang,Marie Luise Brennan,Xiaoming Fu,Ronnier J. Aviles,Gregory L. Pearce,Marc S. Penn,Eric J. Topol,Dennis L. Sprecher,Stanley L. Hazen +8 more
TL;DR: Elevated levels of leukocyte- and blood-MPO are associated with the presence of CAD, and a potential role for MPO as an inflammatory marker in CAD is supported and may have implications for atherosclerosis diagnosis and risk assessment.
Journal ArticleDOI
Myeloperoxidase and Cardiovascular Disease
TL;DR: Myeloperoxidase is a leukocyte-derived enzyme that catalyzes the formation of a number of reactive oxidant species that represent attractive targets for both prognostication and therapeutic intervention in the prophylaxis of atherosclerotic cardiovascular disease.
Journal ArticleDOI
Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease
Lemin Zheng,Benedicta Nagella Nukuna,Marie Luise Brennan,Mingjiang Sun,Marlene Goormastic,Megan Settle,Dave Schmitt,Xiaoming Fu,Leonor Thomson,Paul L. Fox,Harry Ischiropoulos,Jonathan D. Smith,Michael Kinter,Stanley L. Hazen +13 more
TL;DR: The present results provide the first direct evidence for apoA-I as a selective target forMPO-catalyzed oxidative modification in human atheroma and suggest a potential mechanism for MPO-dependent generation of a proatherogenic dysfunctional form of HDL in vivo.
Journal ArticleDOI
Reactive oxygen species in cardiovascular disease.
Koichi Sugamura,John F. Keaney +1 more
TL;DR: The understanding of reactive oxygen species has evolved to the point at which it is now realize these species have important roles in physiology as well as pathophysiology, and it is overly simplistic to assume a general antioxidant strategy will yield specific effects on cardiovascular disease.
Journal ArticleDOI
Mammalian heme peroxidases: from molecular mechanisms to health implications.
TL;DR: Recent developments in the understanding of the enzymology, chemistry, biochemistry and biologic roles of mammalian peroxidases and the oxidants that they generate are reviewed, the potential role of these oxidants in human disease, and the use of the levels of these enzymes in disease prognosis are reviewed.
References
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Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
TL;DR: Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.
Book
Heart Disease: A Textbook of Cardiovascular Medicine
TL;DR: The Cardiovascular Disease and Disorders of other Organ Systems chapter discussesCardiovascular Disease in Special Populations, Disorders of the Heart, Pericardium and Pulmonary Vascular Bed, and Molecular Biology and Genetics.
Book
Applied Logistic Regression Analysis
TL;DR: The second edition of the Second Edition of the Logistic regression model as discussed by the authors is the most complete version of the first edition and includes a discussion of the relationship between linear regression and logistic regression.