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A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives
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This article is published in Journal of the American Chemical Society.The article was published on 1992-12-01. It has received 483 citations till now. The article focuses on the topics: Solid-phase synthesis & Aminoketone.read more
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The combinatorial synthesis of bicyclic privileged structures or privileged substructures
TL;DR: Privileged substructures are believed to achieve this through the mimicry of common protein surface elements that are responsible for binding, such as β- and gamma;-turns.
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Target-oriented and diversity-oriented organic synthesis in drug discovery.
TL;DR: Several synthetic planning principles for diversity-oriented synthesis and their role in the drug discovery process are presented in this review.
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Synthesis and Applications of Small Molecule Libraries.
TL;DR: Thompson et al. as mentioned in this paper developed a method for the generation of large combinatorial libraries of peptides and oligonucleotides that are then screened against a receptor or enzyme to identify high affinity ligands or potent inhibitors, respectively.
Patent
High throughput screening assay systems in microscale fluidic devices
TL;DR: In this paper, the authors present novel microfluidic devices and methods that are useful for performing high-throughput screening assays for a variety of chemical and biochemical systems.
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Multiple-Component Condensation Strategies for Combinatorial Library Synthesis
TL;DR: This Account focuses on multiple-component condensations (MCCs) as one subset of strategies for the generation of compound libraries, and it is instructive to contrast this approach with linear synthesis to highlight the differences in methods, potential library size, and output format.