Journal ArticleDOI
A genetic switch: Gene control and phage lambda
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This article is published in Bulletin of Mathematical Biology.The article was published on 1987-01-01. It has received 39 citations till now. The article focuses on the topics: Lambda phage.read more
Citations
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Journal ArticleDOI
Genetic circuit design automation
Alec A. K. Nielsen,Bryan S. Der,Bryan S. Der,Jonghyeon Shin,Prashant Vaidyanathan,Vanya Paralanov,Elizabeth A. Strychalski,David J. Ross,Douglas Densmore,Christopher A. Voigt +9 more
TL;DR: Electronic design automation principles from EDA are applied to enable increased circuit complexity and to simplify the incorporation of synthetic gene regulation into genetic engineering projects, and it is demonstrated that engineering principles can be applied to identify and suppress errors that complicate the compositions of larger systems.
Journal ArticleDOI
The Cpx envelope stress response is controlled by amplification and feedback inhibition
TL;DR: The ability to autoactivate and then subsequently repress allows for a temporary amplification of the Cpx response that may be important in rescuing cells from transitory stresses and cueing the appropriately timed elaboration of virulence factors.
Journal ArticleDOI
Bimodal and graded expression of the Xenopus homeobox gene Xhox3 during embryonic development.
TL;DR: A role for homeobox genes in the patterning of the A-P embryonic axis is proposed based on results of analysis of Xhox3 expression in experimentally perturbed embryos and those with other frog homeOBox genes.
Journal ArticleDOI
Advances in genetic circuit design: novel biochemistries, deep part mining, and precision gene expression.
TL;DR: New approaches to obtain precise gene expression and to reduce context dependence that will accelerate circuit design by more reliably balancing regulators while reducing toxicity are described.
Journal ArticleDOI
Positive-feedback loops as a flexible biological module.
TL;DR: In the presence of feedback, transient induction with high pheromone levels caused persistent pathway activation, whereas at lower levels a fraction of cells became persistently active but the rest inactivated completely.
References
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Journal ArticleDOI
Genetic circuit design automation
Alec A. K. Nielsen,Bryan S. Der,Bryan S. Der,Jonghyeon Shin,Prashant Vaidyanathan,Vanya Paralanov,Elizabeth A. Strychalski,David J. Ross,Douglas Densmore,Christopher A. Voigt +9 more
TL;DR: Electronic design automation principles from EDA are applied to enable increased circuit complexity and to simplify the incorporation of synthetic gene regulation into genetic engineering projects, and it is demonstrated that engineering principles can be applied to identify and suppress errors that complicate the compositions of larger systems.
Journal ArticleDOI
The Cpx envelope stress response is controlled by amplification and feedback inhibition
TL;DR: The ability to autoactivate and then subsequently repress allows for a temporary amplification of the Cpx response that may be important in rescuing cells from transitory stresses and cueing the appropriately timed elaboration of virulence factors.
Journal ArticleDOI
Bimodal and graded expression of the Xenopus homeobox gene Xhox3 during embryonic development.
TL;DR: A role for homeobox genes in the patterning of the A-P embryonic axis is proposed based on results of analysis of Xhox3 expression in experimentally perturbed embryos and those with other frog homeOBox genes.
Journal ArticleDOI
Advances in genetic circuit design: novel biochemistries, deep part mining, and precision gene expression.
TL;DR: New approaches to obtain precise gene expression and to reduce context dependence that will accelerate circuit design by more reliably balancing regulators while reducing toxicity are described.
Journal ArticleDOI
Positive-feedback loops as a flexible biological module.
TL;DR: In the presence of feedback, transient induction with high pheromone levels caused persistent pathway activation, whereas at lower levels a fraction of cells became persistently active but the rest inactivated completely.