Organs-on-chips at the frontiers of drug discovery
TLDR
The new opportunities for the application of organ-on-chip technologies in a range of areas in preclinical drug discovery, such as target identification and validation, target-based screening, and phenotypic screening are examined.Abstract:
Microengineered cell culture systems are becoming sufficiently sophisticated that they can recapitulate many of the phenomena observed in tissues and organisms. Here, Huh and colleagues discuss the advances made in these 'organs-on-chips' and how they could be used in drug development, including target identification and validation, toxicity screening and stratified medicine.read more
Citations
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Modeling Physiological Events in 2D vs. 3D Cell Culture.
Kayla Duval,Hannah Grover,Li-Hsin Han,Yongchao Mou,Adrian F. Pegoraro,Jeffery J. Fredberg,Zi Chen +6 more
TL;DR: 2D and 3D cell culture methods are reviewed, advantages and limitations of these techniques in modeling physiologically and pathologically relevant processes are discussed, and directions for future research are suggested.
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After asthma: redefining airways diseases
Ian D. Pavord,Richard Beasley,Alvar Agusti,Gary P. Anderson,Elisabeth H. Bel,Guy Brusselle,Guy Brusselle,Paul Cullinan,Adnan Custovic,Francine M. Ducharme,John V. Fahy,Urs Frey,Peter G. Gibson,Peter G. Gibson,Liam G Heaney,Patrick G. Holt,Marc Humbert,Marc Humbert,Clare M. Lloyd,Guy B. Marks,Fernando D. Martinez,Peter D. Sly,Erika von Mutius,Sally E. Wenzel,Heather J. Zar,Andrew Bush +25 more
TL;DR: The only way to make progress in the future is to be much more clear about the meaning of the labels used for asthma and to acknowledge the assumptions associated with them, which are believed to be the most important causes of the stagnation in key clinical outcomes observed in the past 10 years.
Journal ArticleDOI
Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery.
Nicholas Ekow Thomford,Dimakatso Alice Senthebane,Arielle Rowe,Daniella Munro,Palesa Seele,Alfred Maroyi,Kevin Dzobo,Kevin Dzobo +7 more
TL;DR: This review discusses plant-based natural product drug discovery and how innovative technologies play a role in next-generation drug discovery.
Journal ArticleDOI
Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip.
Yu Shrike Zhang,Yu Shrike Zhang,Yu Shrike Zhang,Andrea Arneri,Simone Bersini,Su Ryon Shin,Kai Zhu,Zahra Goli-Malekabadi,Julio Aleman,Cristina Colosi,Fabio Busignani,Valeria Dell’Erba,Colin E. Bishop,Thomas Shupe,Danilo Demarchi,Matteo Moretti,Marco Rasponi,Mehmet R. Dokmeci,Anthony Atala,Ali Khademhosseini +19 more
TL;DR: It is demonstrated that the method for generation of endothelialized organoids fabricated through an innovative 3D bioprinting technology may find widespread applications in regenerative medicine, drug screening, and potentially disease modeling.
Journal ArticleDOI
Three-dimensional culture systems in cancer research: Focus on tumor spheroid model
Sritama Nath,Gayathri R. Devi +1 more
TL;DR: This review attempts to summarize the various 3D culture systems, with an emphasis on the most well characterized and widely applied model - multicellular tumor spheroids.
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