A miniature all-optical photoacoustic imaging probe
Edward Z. Zhang,Paul C. Beard +1 more
TLDR
In this article, a photoacoustic probe for endoscopic applications was developed, which consists of a single delivery optical fiber with a transparent Fabry Perot (FP) ultrasound sensor at its distal end.Abstract:
A miniature (250 μm outer diameter) photoacoustic probe for endoscopic applications has been developed. It comprises
a single delivery optical fibre with a transparent Fabry Perot (FP) ultrasound sensor at its distal end. The fabrication of
the sensor was achieved by depositing a thin film multilayer structure comprising a polymer spacer sandwiched
between a pair of dichroic dielectric mirrors on to the tip of a single mode fiber. The probe was evaluated in terms of its
acoustic bandwidth and sensitivity. Ultra high acoustic sensitivity has been achieved with a concave FP interferometer
cavity design, which effectively suppresses the phase dispersion of multiple reflected beam within the cavity to achieve
high finesse. The noise equivalent noise (NEP) achieved is 8 Pa over a 20 MHz bandwidth. Backward mode operation
of the probe is demonstrated by detecting photoacoustic signals in a variety of phantoms designed to simulate
endoscopic applications. A side-viewing probe is also demonstrated illustrating an all-optical design for intravascular
imaging applications.read more
Figures
Figure 3: Interferometer transfer function (ITF) of the concave cavity FP sensor probe. 
Figure 2: Photo of concave cavity FP sensor probe. 
Figure 6: (A) A sideways looking probe with a concave cylindrical FP sensor cavity (B) PA signal produced by the absorption of 1064nm pulsed laser light incident on a black absorber. This signal was detected with the probe operating in forward mode. 
Figure 7: A sideways looking probe with a concave cylindrical FP sensor cavity. 
Figure 1: (A) Schematic of the all-optical endoscopic imaging system. (B) Forward looking probe. (C) Sideways looking scanning probe. 
Figure 4: Noise equivalent pressure of the concave FP sensor probe vs optical interrogation power.
Citations
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TL;DR: The fundamentals of photoacoustic tomography are reviewed and practical guidelines for matching PAT systems with research needs are provided, and the most promising biomedical applications of PAT are summarized.
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Junjie Yao,Lihong V. Wang +1 more
TL;DR: Focusing on state-of-the-art developments in PAM, this Review discusses the key features of PAM implementations and their applications in biomedical studies.
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Sensitivity of photoacoustic microscopy
Junjie Yao,Lihong V. Wang +1 more
TL;DR: The detection sensitivity of PAM is discussed, the detection efficiency of different PAM designs are compared, and the imaging performance of various endogenous and exogenous contrast agents is summarized.
References
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Backward-mode multiwavelength photoacoustic scanner using a planar Fabry-Perot polymer film ultrasound sensor for high-resolution three-dimensional imaging of biological tissues
TL;DR: It is considered that this type of instrument may provide a practicable alternative to piezoelectric-based photoacoustic systems for high-resolution structural and functional imaging of the skin microvasculature and other superficial structures.
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In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy
TL;DR: It is considered that this type of instrument may find a role in the clinical assessment of conditions characterized by changes in the vasculature such as skin tumours and superficial soft tissue damage due to burns, wounds or ulceration.
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A Fabry–Pérot fiber-optic ultrasonic hydrophone for the simultaneous measurement of temperature and acoustic pressure
TL;DR: A dual sensing fiber-optic hydrophone that can make simultaneous measurements of acoustic pressure and temperature at the same location has been developed and showed that the sensor is not susceptible to viscous heating, is able to withstand high intensity fields, and can simultaneously acquire acoustic waveforms while monitoring induced temperature rises.
Journal ArticleDOI
Optical fiber photoacoustic-photothermal probe.
TL;DR: The ability of the all-optical probe to make photoacoustic and photothermal measurements simultaneously and evaluate its photothermal response, using a nonscattering liquid target of known and adjustable absorption coefficient is demonstrated.