Journal ArticleDOI
A new prognostic system for hepatocellular carcinoma: A retrospective study of 435 patients
Giuseppe Manghisi,Silvana Elba,Ascanio Mossa,Antonio Giorgio,V Aloisio,A. Perrotta,Berardino Tardio,Carlo Del Naja,Eugenio Caturelli,Maria Calandra,L. Castellano,Ilario de Sio,Gaetano Capuano,Domenico Pomponi,Fabiana Castiglione,Pasqualina Cocchia,Fabio Farinati,M. Rinaldi,Luigi Elio Adinolfi,Enrico Ragone,Martina Felder,Laura Zancanella,Giuseppe Pasquale,Maria Stanzione,Giampiero Marone,Valentina D’Angelo,Giovanni Battista Gaeta,Giancarlo Giolitto,Bruno Lamborgese,Luigi Manzione,Michele Russo,Raffaele Colurcio,Enzo Veltri,Francesco Izzo,Gabriele Budillon,Nicola Caporaso,Camillo Del Vecchio Blanco,B. Galanti,Giuseppe Giusti,Gabriele Mazzacca,Silvio Monfardini,Felice Piccinino,Giuseppe Ruggiero,Ciro Gallo,Francesco Perrone,Sabino De Placido,Giuliana Canzanella,Bruno Daniele,Sandro Pignata +48 more
TLDR
The aims of this study were to verify the value of known prognostic factors and to devise a prognostic index more sensitive than the commonly used Okuda stage, and to produce a new prognostic system that accounts for both liver function and tumor characteristics.About:
This article is published in Hepatology.The article was published on 1998-01-01. It has received 1218 citations till now. The article focuses on the topics: Hepatocellular carcinoma & Retrospective cohort study.read more
Citations
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Journal ArticleDOI
EASL-EORTC clinical practice guidelines : management of hepatocellular carcinoma
Peter R. Galle,Alejandro Forner,Josep M. Llovet,Vincenzo Mazzaferro,Fabio Piscaglia,Jean-Luc Raoul,Peter Schirmacher,Valérie Vilgrain +7 more
TL;DR: The following Clinical Practice Guidelines will give up-to-date advice for the clinical management of patients with hepatocellular carcinoma, as well as providing an in-depth review of all the relevant data leading to the conclusions herein.
AASLD PRACTICE GUIDELINE Management of Hepatocellular Carcinoma: An Update
Jordi Bruix,Morris Sherman +1 more
TL;DR: Since the publication of the American Association for the Study of Liver Diseases (AASLD) practice guidelines on the management of hepatocellular carcinoma (HCC) in 2005, new information has emerged that requires that the guidelines be updated.
Journal ArticleDOI
Management of hepatocellular carcinoma.
Jordi Bruix,Morris Sherman +1 more
TL;DR: The prevention of Cirrhosis can prevent the development of HCC and progression from chronic HCV infection to advanced fibrosis or cirrhosis may be prevented in 40% of patients who are sustained responders to new antiviral strategies, such as pegylated interferon and ribavirin.
Journal ArticleDOI
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial.
Ann-Lii Cheng,Yoon-Koo Kang,Zhendong Chen,Chao Jung Tsao,Shukui Qin,Jun Suk Kim,Rongcheng Luo,Jifeng Feng,Sheng-Long Ye,Tsai Sheng Yang,Jianming Xu,Yan Sun,Houjie Liang,Jiwei Liu,Jiejun Wang,Won Young Tak,Hongming Pan,Karin Burock,Jessie Zou,D. Voliotis,Zhongzhen Guan +20 more
TL;DR: Sorafenib is effective for the treatment of advanced hepatocellular carcinoma in patients from the Asia-Pacific region, and is well tolerated.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Book ChapterDOI
Regression Models and Life-Tables
TL;DR: The analysis of censored failure times is considered in this paper, where the hazard function is taken to be a function of the explanatory variables and unknown regression coefficients multiplied by an arbitrary and unknown function of time.
Journal Article
Evaluation of survival data and two new rank order statistics arising in its consideration.
Journal ArticleDOI
Transection of the oesophagus for bleeding oesophageal varices
TL;DR: Emergency ligation of bleeding oesophageal varices using the Milnes Walker technique was performed in 38 patients, and in patients with good preoperative liver function this rose to 71% and the simple scoring system for grading the severity of disturbance of liver function was found to be of value in predicting the outcome of surgery.
Journal ArticleDOI
Natural history of hepatocellular carcinoma and prognosis in relation to treatment study of 850 patients
Kunio Okuda,Toshio Ohtsuki,Hiroshi Obata,Masahiko Tomimatsu,Nobuo Okazaki,Hiroshi Hasegawa,Yukio Nakajima,Kunihiko Ohnishi +7 more
TL;DR: Results in survival are much improved over the past reports, and the differences are probably a result of earlier diagnosis and frequent hepatic resection, probably due to the coexistent advanced cirrhosis.
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Sorafenib in Advanced Hepatocellular Carcinoma
Josep M. Llovet,Sergio Ricci,Vincenzo Mazzaferro,Philip Hilgard,Edward Gane,Jean-Frédéric Blanc,André Cosme de Oliveira,Armando Santoro,Jean-Luc Raoul,Alejandro Forner,Myron Schwartz,Camillo Porta,Stefan Zeuzem,Luigi Bolondi,Tim F. Greten,Peter R. Galle,Jean Francois Seitz,Ivan Borbath,Dieter Häussinger,Tom Giannaris,Minghua Shan,M. Moscovici,D. Voliotis,Jordi Bruix +23 more