Journal ArticleDOI
A Radiating System for Low-Frequency Highly Focused Hyperthermia With Magnetic Nanoparticles
Danilo Brizi,Nunzia Fontana,Giulio Giovannetti,Luca Menichetti,Laura Cappiello,Saer Doumett,Costanza Ravagli,Giovanni Baldi,Agostino Monorchio +8 more
- Vol. 4, Iss: 2, pp 109-116
TLDR
In this article, the authors proposed a radiofrequency (RF) radiating system for highly focused hyperthermia with magnetic nanoparticles, where a coil was designed to focus the magnetic field at the frequency that maximizes the heat release from the chosen nanoparticles.Abstract:
In this paper, we propose a radiofrequency (RF) radiating system for highly focused hyperthermia with magnetic nanoparticles. We first designed a coil able to focus the magnetic field at the frequency (around 340 kHz) that maximizes the heat release from the chosen nanoparticles. Then, through an electromagnetic software based on the Method of Moments (MoM), we performed numerical simulations of the coil that resulted in excellent agreement with the experimental measurements conducted at the workbench on a fabricated prototype. After that, a radiating system consisting of the coil, a high-power radiofrequency signal generator, and a set of magnetic nanoparticles have been set up. We carried out several experimental trials with different samples of magnetic nanoparticles in order to demonstrate the focusing property of the proposed system. The results we obtained suggested that a careful design of the radiating system could pave the way towards more efficient and safer magnetic hyperthermia treatments in clinical applications.read more
Citations
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Journal ArticleDOI
Magnetic Hyperthermia in the 400–1,100 kHz Frequency Range Using MIONs of Condensed Colloidal Nanocrystal Clusters
Dimitris Kouzoudis,Georgios Samourgkanidis,Argiris Kolokithas-Ntoukas,Giorgio Zoppellaro,Konstantinos Spiliotopoulos +4 more
TL;DR: In this paper, an AC magnetic field of 3mT amplitude was produced over a range of 400 kHz to 1.1 MHz and applied to a dilute aqueous ferrofluid solution composed of ferrous magnetic nanoparticles.
Journal ArticleDOI
Shaping and Focusing Magnetic Field in the Human Body: State-of-the Art and Promising Technologies
Sabrina Rotundo,Danilo Brizi,Alessandra Flori,Giulio Giovannetti,Luca Menichetti,D. Monorchio +5 more
TL;DR: This review paper directs the interest toward hyperthermia with magnetic nanoparticles and transcranial magnetic stimulation, together with a brief mention of magnetic resonance imaging, and deeply review the technological solutions that have appeared so far in the literature to shape and control the radio frequency magnetic field distribution within biological tissues, highlighting human applications.
Proceedings ArticleDOI
A feasibility study of a radio-frequency theranostic device for tumor localization and treatment
TL;DR: The observed results reveal the potential of an innovative tunable near-field clinical device, to be employed in future for non-invasive detection and treatment of internal malign neoplasms, thus encouraging further analysis.
Journal ArticleDOI
Millimetric Inclusion Detection Through a Contactless Microwave Spiral Sensor for Biomedical Applications
TL;DR: In this paper, a microwave contactless sensor is used to detect the presence of millimetric inclusions in a biological medium for biomedical applications, which is achieved by recording both the amplitude variation and the frequency shift of the input impedance of the reading probe.
Journal ArticleDOI
Development of handheld induction heaters for magnetic fluid hyperthermia applications and in-vitro evaluation on ovarian and prostate cancer cell lines
TL;DR: In this article , a laparoscopic induction heater (LIH) and a transrectal induction heater(TRIH) were developed to reach around 41 °C-47 °C in the tumor site by exciting magnetic nanoparticles with an externally applied alternating magnetic field (AMF), where cell death is expected to occur.
References
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Journal ArticleDOI
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