Journal ArticleDOI
A randomized trial of the long-term, continued efficacy and safety of modafinil in narcolepsy.
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TLDR
Modafinil continues to be an effective and well-tolerated drug after 16 weeks of treatment with no significant effects on nocturnal sleep, blood pressure, heart rate, the electrocardiogram (ECG), weight, or mood.About:
This article is published in Sleep Medicine.The article was published on 2000-04-01. It has received 118 citations till now. The article focuses on the topics: Modafinil & Epworth Sleepiness Scale.read more
Citations
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Journal ArticleDOI
Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application.
TL;DR: A diversity of multi-target strategies are proposed for the more efficacious and rapid control of core and co-morbid symptoms of depression, together with improved tolerance relative to currently available agents.
Journal ArticleDOI
Cognitive enhancing effects of modafinil in healthy volunteers.
Danielle C. Turner,Trevor W. Robbins,Luke Clark,Adam R. Aron,Jonathan H. Dowson,Barbara J. Sahakian +5 more
TL;DR: Data indicate that modafinil selectively improves neuropsychological task performance, suggesting that modAFinil may be of benefit in the treatment of attention deficit hyperactivity disorder.
Journal ArticleDOI
Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin.
Timothy I. Morgenthaler,Vishesh K. Kapur,Terry Brown,Todd J. Swick,Cathy A. Alessi,R. Nisha Aurora,Brian Boehlecke,Andrew L. Chesson,Leah Friedman,Rama Maganti,Judith A. Owens,Jeffrey Pancer,Rochelle S. Zak +12 more
TL;DR: These practice parameters serve as both an update of previous practice parameters for the therapy of narcolepsy and as the first practice parameters to address treatment of other hypersomnias of central origin, based on evidence analyzed in the accompanying review paper.
Journal ArticleDOI
Modafinil as Adjunct Therapy for Daytime Sleepiness in Obstructive Sleep Apnea
TL;DR: Modafinil may be a useful adjunct treatment for the management of residual daytime sleepiness in patients with obstructive sleep apnea/hypopnea syndrome who are regular users of nasal continuous positive airway pressure therapy.
Journal ArticleDOI
EFNS guidelines on management of narcolepsy.
Michel Billiard,Claudio L. Bassetti,Yves Dauvilliers,Leja Dolenc-Groselj,Gert Jan Lammers,Geert Mayer,T. Pollmacher,Paul Reading,Karel Sonka +8 more
TL;DR: A task force composed of the leading specialists of narcolepsy in Europe conducted an extensive review of pharmacological and behavioral trials available in the literature to reinforce the use of those drugs evaluated in randomized placebo‐controlled trials and to reach a consensus, as much as possible, on theUse of other available medications.
References
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Journal ArticleDOI
A new method for measuring daytime sleepiness: the Epworth sleepiness scale.
TL;DR: The development and use of a new scale, the Epworth sleepiness scale (ESS), is described, which is a simple, self-administered questionnaire which is shown to provide a measurement of the subject's general level of daytime sleepiness.
Journal ArticleDOI
Maintenance of wakefulness test: A polysomnographic technique for evaluating treatment efficacy in patients with excessive somnolence ☆
TL;DR: The findings suggested that clinical data on symptom control in narcolepsy do not predict ability to stay awake, and objective measures of the ability are potentially more useful in evaluating treatment.
Journal ArticleDOI
Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy
TL;DR: Modafinil demonstrated an excellent safety profile for up to 40 weeks of open‐label treatment and efficacy was maintained, suggesting that tolerance will not develop with long‐term use.
Journal ArticleDOI
Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil.
Hélène Bastuji,M Jouvet +1 more
TL;DR: Modafinil, a putative central alpha 1 adrenergic agonist, was tested in idiopathic hypersomnia and narcolepsy and produces, in most cases, no peripheric sides effects, does not disturb night sleep and is never responsible of tolerance of drug dependence.
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