Journal ArticleDOI
A review and meta-analysis of the genetic epidemiology of anxiety disorders.
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TLDR
Meta-analyses of data from family and twin studies of panic disorder, generalized anxiety disorder, phobias, and obsessive-compulsive disorder revealed significant familial aggregation, underscoring the importance of identifying putative environmental risk factors that predispose individuals to anxiety.Abstract:
OBJECTIVE: The authors conducted meta-analyses of data from family and twin studies of panic disorder, generalized anxiety disorder, phobias, and obsessive-compulsive disorder (OCD) to explore the roles of genetic and environmental factors in their etiology. METHOD: MEDLINE searches were performed to identify potential primary studies of these disorders. Data from studies that met inclusion criteria were incorporated into meta-analyses that estimated summary statistics of aggregate familial risk and heritability for each disorder. RESULTS: For family studies, odds ratios predicting association of illness in first-degree relatives with affection status of the proband (disorder present or absent) were homogeneous across studies for all disorders. The calculated summary odds ratios ranged from 4 to 6, depending on the disorder. Only for panic disorder and generalized anxiety disorder could the authors identify more than one large-scale twin study for meta-analysis. These yielded heritabilities of 0.43 for pa...read more
Citations
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Journal ArticleDOI
The brain basis of emotion: A meta-analytic review
TL;DR: A meta-analytic summary of the neuroimaging literature on human emotion finds little evidence that discrete emotion categories can be consistently and specifically localized to distinct brain regions, and finds evidence that is consistent with a psychological constructionist approach to the mind.
Journal ArticleDOI
Methodology for Genetic Studies of Twins and Families
TL;DR: The saimie paper suggests how susceptible individuals could reduce their total intake of aluminium and suggests that although definite proof is still lacking, there is more than enough evidence to fuel further epidemiological investigation.
Journal ArticleDOI
Anxiety and Anxiety Disorders in Children and Adolescents: Developmental Issues and Implications for DSM-V
TL;DR: Epidemiological evidence covering prevalence, incidence, course, and risk factors of anxiety disorders among children and adolescents is reviewed for improved early recognition and differential diagnosis as well as prevention and treatment.
Journal ArticleDOI
Cultural variation in affect valuation.
TL;DR: It is proposed that how people want to feel differs from how they actually feel ("ideal affect") and that cultural factors influence ideal more than actual affect and that both play a role in mental health.
Journal ArticleDOI
The neurobiology and control of anxious states
TL;DR: The present article focuses in particular upon the multifarious and complex roles of individual modulators, often as a function of the specific receptor type and neuronal substrate involved in their actions; novel targets for the management of anxiety disorders; the influence of neurotransmitters and other agents upon performance in the VCT; data acquired from complementary pharmacological and genetic strategies and, finally, several open questions likely to orientate future experimental- and clinical-research.
References
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Journal ArticleDOI
Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease
Nathan Mantel,William Haenszel +1 more
TL;DR: In this paper, the role and limitations of retrospective investigations of factors possibly associated with the occurrence of a disease are discussed and their relationship to forward-type studies emphasized, and examples of situations in which misleading associations could arise through the use of inappropriate control groups are presented.
Journal ArticleDOI
Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States: Results From the National Comorbidity Survey
Ronald C. Kessler,Katherine A. McGonagle,Shanyang Zhao,Christopher B. Nelson,Michael R. Hughes,Suzann Eshleman,Hans-Ulrich Wittchen,Kenneth S. Kendler +7 more
TL;DR: The prevalence of psychiatric disorders is greater than previously thought to be the case, and morbidity is more highly concentrated than previously recognized in roughly one sixth of the population who have a history of three or more comorbid disorders.
Book
Methodology for Genetic Studies of Twins and Families
Michael C. Neale,Lon R. Cardon +1 more
TL;DR: The LISREL Script for Rater Bias Model and Data for Simplex Model as mentioned in this paper is one of the most well-known models in the literature for gene expression analysis.
Journal ArticleDOI
Methodology for Genetic Studies of Twins and Families
TL;DR: The saimie paper suggests how susceptible individuals could reduce their total intake of aluminium and suggests that although definite proof is still lacking, there is more than enough evidence to fuel further epidemiological investigation.
Journal ArticleDOI
A family study of obsessive-compulsive disorder.
TL;DR: The relatives of female probands with obsessive-compulsive disorder were more likely to have tics, and the relatives of Probands with early onset were at higher risk for both obsessive-Compulsive disorder and tics.