Journal ArticleDOI
A role for matrix metalloproteinase-9 in spontaneous rupture of the fetal membranes.
Neil Athayde,Samuel S. Edwin,Roberto Romero,Ricardo Gomez,Eli Maymon,Percy Pacora,Ramkumar Menon +6 more
TLDR
A role for matrix metalloproteinase-9 in the mechanisms responsible for membrane rupture in term and preterm gestations is supported, and spontaneous rupture of membranes at term is associated with a significant increase in the amniotic fluid concentrations of matrix meetallop Proteinase 9.About:
This article is published in American Journal of Obstetrics and Gynecology.The article was published on 1998-11-01. It has received 208 citations till now. The article focuses on the topics: Premature rupture of membranes & Amniotic fluid.read more
Citations
More filters
Journal ArticleDOI
The preterm parturition syndrome
Roberto Romero,Jimmy Espinoza,Juan Pedro Kusanovic,Francesca Gotsch,Sonia S. Hassan,Offer Erez,Tinnakorn Chaiworapongsa,Moshe Mazor +7 more
TL;DR: The evidence indicating that the pathological processes implicated in the preterm parturition syndrome include: intrauterine infection/inflammation; uterine ischaemia; (3) uterine overdistension; (4) abnormal allograft reaction; (5) allergy; (6) cervical insufficiency; and (7) hormonal disorders (progesterone related and corticotrophin‐releasing factor related).
Journal ArticleDOI
Cytokines, Prostaglandins and Parturition—A Review
Jeffrey A. Keelan,Marion Blumenstein,Rachel J. A. Helliwell,Timothy A. Sato,K.W. Marvin,Murray D. Mitchell +5 more
TL;DR: Patterns of expression of cytokines in the foetal membranes and decidua suggest that inflammatory activation occurs modestly with term labour, but much more robustly in preterm delivery, particularly in the presence of intrauterine infection.
Journal ArticleDOI
The fetal inflammatory response syndrome.
Francesca Gotsch,Roberto Romero,Juan Pedro Kusanovic,Shali Mazaki-Tovi,Beth L. Pineles,Offer Erez,Jimmy Espinoza,Sonia S. Hassan +7 more
TL;DR: A systemic fetal inflammatory response, as determined by an elevated fetal plasma interleukin-6 value, is an independent risk factor for the occurrence of severe neonatal morbidity.
Journal ArticleDOI
The Contribution of Maternal Stress to Preterm Birth: Issues and Considerations
TL;DR: Key issues and questions highlighting the need to develop a better understanding of which particular subgroups of pregnant women may be especially vulnerable to the potentially detrimental effects of maternal stress are addressed.
Journal ArticleDOI
Prevalence and Clinical Significance of Sterile Intra‐amniotic Inflammation in Patients with Preterm Labor and Intact Membranes
Roberto Romero,Jezid Miranda,Jezid Miranda,Tinnakorn Chaiworapongsa,Tinnakorn Chaiworapongsa,Steven J. Korzeniewski,Steven J. Korzeniewski,Piya Chaemsaithong,Piya Chaemsaithong,Francesca Gotsch,Zhong Dong,Zhong Dong,Ahmed I. Ahmed,Ahmed I. Ahmed,Bo Hyun Yoon,Sonia S. Hassan,Sonia S. Hassan,Chong Jai Kim,Chong Jai Kim,Lami Yeo,Lami Yeo +20 more
TL;DR: The relationship between amniotic fluid concentrations of high mobility group box‐1 (HMGB1) and the interval from amniocentesis to delivery in patients with sterile intra‐amniotic inflammation is examined.
References
More filters
Journal ArticleDOI
Matrix metalloproteinases and their inhibitors in connective tissue remodeling.
TL;DR: Latency is overcome by physical, chemical, and enzymatic treatments that separate the cysteine residue from the zinc Expression of the metalloproteinases is switched on by a variety of agents acting through regulatory elements of the gene, particularly the AP‐1 binding site.
Journal ArticleDOI
Metalloproteinases and their inhibitors in matrix remodeling.
TL;DR: Experiments designed to improve the understanding of metalloproteinase regulation have also resulted in new insights into mechanisms by which growth factors and proto-oncogenes may regulate biological processes.
Journal ArticleDOI
Premature Rupture of the Fetal Membranes
Samuel Parry,Jerome F. Strauss +1 more
TL;DR: The membranes surrounding theAmniotic cavity are composed of the amnion and the chorion, which are closely adherent layers consisting of several cell types, including epithelial cells, mesenchymal cells, and trophoblast cells, embedded in a collagenous matrix.
Journal ArticleDOI
Human 92- and 72-kilodalton type IV collagenases are elastases.
R. M. Senior,G. L. Griffin,C. J. Fliszar,Steven D. Shapiro,Gregory Goldberg,Howard G. Welgus +5 more
TL;DR: The spectrum of human proteinases with elastolytic activity to metalloproteinases is extended and the enzymatic basis for elastase activity observed with certain cell types such as human alveolar macrophages is suggested.