A specific ligand for β2-glycoprotein I mediates autoantibody-dependent uptake of oxidized low density lipoprotein by macrophages
Kazuko Kobayashi,Eiji Matsuura,Qingping Liu,Jun-ichi Furukawa,Keiko Kaihara,Junko Inagaki,Tatsuya Atsumi,Nobuo Sakairi,Tatsuji Yasuda,Dennis R. Voelker,Takao Koike +10 more
TLDR
It is suggested that autoimmune atherogenesis linked to beta(2)-GPI interaction with oxLDL and Abs may be present in APS.About:
This article is published in Journal of Lipid Research.The article was published on 2001-05-01 and is currently open access. It has received 144 citations till now. The article focuses on the topics: Beta 2-Glycoprotein I & Low-density lipoprotein.read more
Citations
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Journal ArticleDOI
Oxidation of LDL and its clinical implication.
TL;DR: Recent progress in the understanding of the clinical significance of oxidation of LDL, formation of oxLDL complexes, and Abs in atherosclerotic and/or autoimmune disease is reviewed.
Journal ArticleDOI
Circulating oxidized LDL forms complexes with β2-glycoprotein I implication as an atherogenic autoantigen
Kazuko Kobayashi,Makoto Kishi,Tatsuya Atsumi,Maria Laura Bertolaccini,Hirofumi Makino,Nobuo Sakairi,Itaru Yamamoto,Tatsuji Yasuda,Munther A. Khamashta,Graham R. V. Hughes,Takao Koike,Dennis R. Voelker,Eiji Matsuura +12 more
TL;DR: It is demonstrated that oxLDL forms stable and nondissociable complexes with beta2-GPI in serum, and that high serum levels of the complexes are associated with arterial thrombosis in APS.
Journal ArticleDOI
Oxidative modification of low-density lipoprotein and immune regulation of atherosclerosis
TL;DR: Recent progress is reviewed in understanding of the mechanisms involved in oxidation of LDL, formation of oxLDL complexes, and antibody mediated-immune regulation of atherogenesis.
Journal ArticleDOI
Is atherosclerosis an autoimmune disease
Eiji Matsuura,Fabiola Atzeni,Piercarlo Sarzi-Puttini,Maurizio Turiel,Luis R. Lopez,Michael T. Nurmohamed +5 more
TL;DR: The chronic inflammatory (innate) and autoimmune (adaptive) responses operating in Atherosclerosis are discussed to discern the role of autoimmunity in atherosclerotic cardiovascular disease.
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Antiphospholipid syndrome infectious origin.
TL;DR: The association of antiphospholipid antibodies in the infectious state, molecular mimicry as a proposed cause for development of APS, and the contribution of the database to this topic are discussed.
References
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TL;DR: In this paper, the authors described a simplified version of the method and reported the results of a study of its application to different tissues, including the efficiency of the washing procedure in terms of the removal from tissue lipides of some non-lipide substances of special biochemical interest.
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Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
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The pathogenesis of atherosclerosis: a perspective for the 1990s
TL;DR: The ability to control the expression of genes encoding these molecules and to target specific cell types provides opportunities to develop new diagnostic and therapeutic agents to induce the regression of the lesions and, possibly, to prevent their formation.
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The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
TL;DR: The relatively low density of the lipoproteins was utilized by Lindgren, Elliott, and Gofman to separate them from the other serum proteins by ultracentrifugal flotation, and quantitation was subsequently performed by refractometric methods in the analytical ultracentRifuge.
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The Pathogenesis of Atherosclerosis — An Update
TL;DR: A response-to-injury hypothesis of atherogenesis proposes that "injury" to the endothelium is the initiating event in atherosclerosis, and intimal smooth-muscle proliferation as the key event in the development of the advanced lesions of Atherosclerosis.