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A study of classification criteria for a diagnosis of juvenile rheumatoid arthritis.

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TLDR
Criteria for the classification of juvenile rheumatoid arthritis were analyzed in a detailed database of 250 children in order to assess the accuracy of diagnosis and validity of onset types and course subtypes.
Abstract
Criteria for the classification of juvenile rheumatoid arthritis were analyzed in a detailed database of 250 children in order to assess the accuracy of diagnosis and validity of onset types and course subtypes. A number of conclusions have been derived from this study: All definitions of the 1973 criteria for classification of juvenile rheumatoid arthritis should be retained. The addition of onset types to the 1976 revision of the criteria has been validated. The course of the disease after the onset period of 6 months is as important to the outcome of a group of children as is the onset type. The current classification should be broadened to include the course subtypes.

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Journal ArticleDOI

Preliminary definition of improvement in juvenile arthritis

TL;DR: Use of a uniform definition of improvement will help standardize the conduct and reporting of clinical trials, and should help practitioners decide if a child with JA has responded adequately to therapy.
Journal ArticleDOI

Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade

TL;DR: It is shown that serum from SoJIA patients induces the transcription of innate immunity genes, including interleukin (IL)-1 in healthy peripheral blood mononuclear cells (PBMCs), and that this cytokine represents a target for therapy in this disease.
Journal ArticleDOI

Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis

TL;DR: These two phase 3 studies show the efficacy and safety of canakinumab in systemic JIA with active systemic features, and among the 100 patients who underwent randomization in the withdrawal phase, the risk of flare was lower among patients who continued to receive canakinUMab than among those who were switched to placebo.
References
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Journal ArticleDOI

HLA-B27-associated spondyloarthritis and enthesopathy in childhood: clinical, pathologic, and radiographic observations in 58 patients.

TL;DR: HLA-B27 typing of all arthritic children helped to identify and focus attention on a subset whose disease was pathogenetically related to and demonstrated clinical features of ankylosing spondylitis and Reiter syndrome, but only rarely fulfilled current diagnostic criteria for those disorders (spondyloarthritis).
Journal Article

Clinical patterns of chronic iridocyclitis in children with juvenile rheumatoid arthritis.

TL;DR: An earlier observation of the association of iridocyclitis with limited joint involvement in children with JRA was reconfirmed, and it was found that 16% of the afflicted children experienced either unilateral or bilateral blindness.
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A number of conclusions have been derived from this study: All definitions of the 1973 criteria for classification of juvenile rheumatoid arthritis should be retained.