Journal ArticleDOI
Abnormal cholesterol distribution among lipoprotein fractions in normolipidemic patients with mild NIDDM
TLDR
In normolipidemic patients with mild NIDDM, the major lipoprotein abnormalities were a low level of HDL cholesterol and compositional changes in LDL and VLDL + IDL fractions, which could have atherogenic potential.About:
This article is published in Atherosclerosis.The article was published on 1995-11-01. It has received 32 citations till now. The article focuses on the topics: Very low-density lipoprotein & Lipoprotein.read more
Citations
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Journal ArticleDOI
The TyG index may predict the development of cardiovascular events
Laura Sánchez-Íñigo,David Navarro-González,Alejandro Fernández-Montero,Juan Pastrana-Delgado,José Alfredo Martínez +4 more
TL;DR: The association between the product of fasting plasma glucose and triglycerides (TyG index) and CVD is evaluated and an early risk detection of apparently healthy people before CVD onset has clinical relevance in the prevention of cardiovascular events.
Journal ArticleDOI
Triglyceride–glucose index (TyG index) in comparison with fasting plasma glucose improved diabetes prediction in patients with normal fasting glucose: The Vascular-Metabolic CUN cohort
David Navarro-González,Laura Sánchez-Íñigo,Juan Pastrana-Delgado,Alejandro Fernández-Montero,J. Alfredo Martínez +4 more
TL;DR: The TyG index seems to be a better predictor than FPG or triglycerides of the potential development of type 2 diabetes in normoglycemic patients and is useful for the early identification of individuals at risk of type 1 diabetes.
Journal ArticleDOI
Ratio of triglycerides to HDL cholesterol is an indicator of LDL particle size in patients with type 2 diabetes and normal HDL cholesterol levels.
TL;DR: The TG-to-HDL cholesterol ratio may be related to the processes involved in LDL size pathophysiology and relevant with regard to the risk of clinical vascular disease and suitable for the selection of patients needing an earlier and aggressive treatment of lipid abnormalities.
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Phospholipase A2 Modification of Low Density Lipoproteins Forms Small High Density Particles with Increased Affinity for Proteoglycans and Glycosaminoglycans
TL;DR: In vitro results indicate that the reduction of surface PL characteristic of small, dense LDL subfractions, besides contributing to its small size and density, may enhance its tendency to be retained by proteoglycans.
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Insulin Resistance in the Pathogenesis of Dyslipidemia
TL;DR: Preliminary results of a study from the laboratory showed that patients with primary hypertriglyceridemia were markedly insulin-resistant and marked lowering of plasma triglyceride levels with n-3 polyunsaturated fatty acid intake did not improve the low rates of insulin-mediated glucose disposal in them, thus indicating that insulin resistance probably is the underlying mechanism in patients withPrimary hypertrigenicemia and not vice versa.
References
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Journal ArticleDOI
Low-Density Lipoprotein Subclass Patterns and Risk of Myocardial Infarction
Melissa A. Austin,Jan L. Breslow,Charles H. Hennekens,Julie E. Buring,Walter C. Willett,Ronald M. Krauss +5 more
TL;DR: The association of low-density lipoprotein (LDL) subclass patterns with coronary heart disease was investigated in a case-control study of nonfatal myocardial infarction and multivariate logistic regression analyses showed that both high-density cholesterol and triglyceride levels contributed to the risk associated with the small, dense LDL subclass pattern.
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Morbidity and Mortality in Diabetics In the Framingham Population: Sixteen Year Follow-up Study
TL;DR: In a sixteen year follow-up study in Framingham, it was found that diabetics in general show an increased morbidity and mortality from all cardiovascular causes and Insulin-treated diabetic women showed the greatest relative mortality from coronary heart disease.
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Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk.
TL;DR: The proposed genetic locus responsible for LDL subclass phenotypes also results in an atherogenic lipoprotein phenotype, found to be closely associated with variations in plasma levels of other lipid, lipop protein, and apolipoprotein measurements.
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A peroxidase-coupled method for the colorimetric determination of serum triglycerides.
TL;DR: This sensitive chromogen system not only permits use of unusually small sample volumes, it also facilitates a linear response to serum triglyceride concentrations up to at least 10 g/L while displaying good Ringbom (measure of accuracy) characteristics.
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Identification of multiple subclasses of plasma low density lipoproteins in normal humans.
Ronald M. Krauss,David J. Burke +1 more
TL;DR: Use of a lipid-staining procedure allowed identification of electrophoretic bands in whole plasma which corresponded to those seen in isolated LDL, eliminating the possibility that ultracentrifugation was responsible for formation of the subspecies detected by the gradient gel procedure.