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Open AccessJournal ArticleDOI

Absence of kynurenine 3-monooxygenase reduces mortality of acute viral myocarditis in mice

Hisako Kubo, +6 more
- 01 Jan 2017 - 
- Vol. 181, pp 94-100
TLDR
It is suggested that increased KP metabolites reduced chemokine production, resulting in suppressed mortality upon KMO knockdown in EMCV infection, and may provide an effective strategy for treating acute viral myocarditis.
About: 
This article is published in Immunology Letters.The article was published on 2017-01-01 and is currently open access. It has received 21 citations till now. The article focuses on the topics: Viral Myocarditis & Kynurenine.

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Citations
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Journal ArticleDOI

Immune Influencers in Action: Metabolites and Enzymes of the Tryptophan-Kynurenine Metabolic Pathway.

Masaru Tanaka, +5 more
- 25 Jun 2021 - 
TL;DR: The TRP-KYN pathway is discussed with special emphasis on its interaction with the immune system and the tolerogenic shift towards chronic LGI and overviews the major symptoms, pro- and anti-inflammatory cytokines and toxic and protective KYNs to explore the linkage between chronicLGI, KYNs, and major psychiatric disorders.
Journal Article

Mast Cells Play a Critical Role in the Pathogenesis of Viral Myocarditis : Two Strains of Mast Cell Deficient Mice Study

Hirokazu Higuchi, +6 more
- 01 Mar 2003 - 
TL;DR: The role of mast cells in heart failure due to viral myocarditis, using two strains of mast cell-deficient mice, WBB6F1-KitW/KitW-v (W/WV) and WCB6F 1-kitlSl/KitlSl-d (Sl/Sld) was examined in this article.
Journal ArticleDOI

Immunomodulatory Effects of Genetic Alterations Affecting the Kynurenine Pathway

Fanni Annamária Boros, +2 more
- 06 Nov 2019 - 
TL;DR: This review summarizes experimental data of models in which IDO, TDO, or KMO activity modulation was achieved by interventions affecting enzyme production at a genomic level and indicates that by eliminating or decreasing activities of key enzymes of the kynurenine pathway, a beneficial shift in disease outcome can be attained.
Journal ArticleDOI

Lactobacillus johnsonii N6.2 diminishes caspase-1 maturation in the gastrointestinal system of diabetes prone rats.

Leandro D. Teixeira, +3 more
- 10 Apr 2018 - 
TL;DR: The role of L. johnsonii in modulating the assembly of the inflammasome as well as some steps of the pro-inflammatory kynurenine pathway is supported.
Journal ArticleDOI

Altered kynurenine pathway metabolites in a mouse model of human attention-deficit hyperactivity/autism spectrum disorders: A potential new biological diagnostic marker.

Yuki Murakami, +6 more
- 12 Sep 2019 - 
TL;DR: The findings indicate that Ptchd1 KO mice can be used as an animal model of human ADHD and/or ASD, and KP metabolites are potential diagnostic biomarkers for neurodevelopmental disorders.
References
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Journal ArticleDOI

Kynurenines in the mammalian brain: when physiology meets pathology

Robert Schwarcz, +3 more
- 01 Jul 2012 - 
TL;DR: With recently developed pharmacological agents, it is now possible to restore metabolic equilibrium and envisage novel therapeutic interventions on the basis of the kynurenine pathway.
Journal ArticleDOI

Tryptophan-derived Catabolites Are Responsible for Inhibition of T and Natural Killer Cell Proliferation Induced by Indoleamine 2,3-Dioxygenase

Guido Frumento, +6 more
- 19 Aug 2002 - 
TL;DR: It is suggested that IDO exerts its effect on cell proliferation by starting the cascade of biochemical reactions that produce the three catabolites and by enhancing their inhibitory potential by depriving the extracellular microenvironment of tryptophan.
Journal ArticleDOI

Inhibition of Allogeneic T Cell Proliferation by Indoleamine 2,3-Dioxygenase–expressing Dendritic Cells Mediation of Suppression by Tryptophan Metabolites

Peter Terness, +6 more
- 19 Aug 2002 - 
TL;DR: Light is shed on suppressive mechanisms mediated by DCs and an explanation for important biological processes in which IDO activity apparently is increased is provided, such as protection of the fetus from rejection during pregnancy and possibly T cell death in HIV-infected patients.
Journal ArticleDOI

Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line

Kouji Matsushima, +3 more
- 01 Apr 1989 - 
TL;DR: This represents the first report of the identification and purification of a chemoattractant cytokine that also activates monocytes but is distinct from interferons and other known cytokines.
Journal ArticleDOI

Kynurenic Acid as a Ligand for Orphan G Protein-coupled Receptor GPR35

Jinghong Wang, +6 more
- 04 Aug 2006 - 
TL;DR: Kynurenic acid stimulates [35S]guanosine 5′-O-(3-thiotriphosphate) binding in GPR35-expressing cells, an effect abolished by pertussis toxin treatment, and inhibits lipopolysaccharide-induced tumor necrosis factor-α secretion in peripheral blood mononuclear cells.
Related Papers (5)

Targeted Deletion of Kynurenine 3-Monooxygenase in Mice: A NEW TOOL FOR STUDYING KYNURENINE PATHWAY METABOLISM IN PERIPHERY AND BRAIN

Flaviano Giorgini, +9 more
- 20 Dec 2013 - 

Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation.

Allison M. Garrison, +6 more
- 01 Aug 2018 - 

Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands

Geoffrey L. Stephens, +5 more
- 01 Jul 2013 - 

Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.

Daniel Zwilling, +24 more
- 10 Jun 2011 - 

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

Damian J. Mole, +26 more
- 01 Feb 2016 -