Journal ArticleDOI
Absence of psychostimulant effects of a supratherapeutic dose of tianeptine: a placebo-controlled study versus methylphenidate in young healthy volunteers.
TLDR
A single administration of a supratherapeutic dose of tianeptine does not induce psychostimulant effect in young healthy volunteers in contrast to methylphenidate at a therapeutic dose, suggesting an absence of psychostIMulant liability of tIANeptine in a therapeutic situation.Abstract:
Objective: The primary objective of the present study was to assess the potential psychostimulant effect of a single oral supratherapeutic dose of tianeptine (75 mg in 1 shot) in young healthy volunteers compared with methylphenidate (40 mg) and placebo. Method: Eighteen healthy young male and female volunteers with no history of psychostimulant abuse completed this balanced, crossover, placebo-controlled study. Subjective and behavioral effects were assessed before treatment and 1, 2, 3, 4, and 8 hours after drug intake. Subjective effects of the drugs were recorded using self-questionnaire Addiction Research Center Inventory (ARCI 49). In addition, the Profile of Mood Scale, Visual Analog Scale, and attention/vigilance tests (choice reaction time and critical flicker fusion test) were used to evaluate mood state, subjective feeling, and sustained attention, respectively. Results: Analysis on changes from baseline, from 1 to 8 hours, showed statistically significant differences between treatment groups for 2 of the 5 ARCI subscales: amphetamine and morphine benzedrine scales. A trend to significance was observed for Lysergic Acid Diethylamide scale. Indeed, although tianeptine did not significantly change any ARCI scores, methylphenidate significantly increased amphetamine and morphine benzedrine scores of the ARCI compared with placebo. No significant treatment effect was observed on the Profile of Mood Scale and the visual analog scale. Analyses of attention and vigilance tests showed a psychostimulant effect for methylphenidate on choice reaction time (decrease of recognition time) and critical flicker fusion test (higher frequency). Conclusions: A single administration of a supratherapeutic dose of tianeptine does not induce psychostimulant effect in young healthy volunteers in contrast to methylphenidate at a therapeutic dose. These findings suggest an absence of psychostimulant liability of tianeptine in a therapeutic situation.read more
Citations
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Journal ArticleDOI
How addictive are gabapentin and pregabalin? A systematic review
Udo Bonnet,Norbert Scherbaum +1 more
TL;DR: The addiction risks of gabapentin and pregabalin are compared with those of traditional psychoactive substances and recommend that in patients with a history of SUD, gabAPentinoids should be avoided or if indispensable, administered with caution by using a strict therapeutic and prescription monitoring.
Journal ArticleDOI
Cognitive effects of methylphenidate in healthy volunteers: a review of single dose studies
TL;DR: It is shown that single doses of MPH improve cognitive performance in the healthy population in the domains of working memory and speed of processing, and to a lesser extent may also improve verbal learning and memory and reasoning and problem solving.
Journal ArticleDOI
The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor
Benjamin Adam Samuels,Katherine M. Nautiyal,Andrew C. Kruegel,Marjorie R Levinstein,Valerie M. Magalong,Madalee M. Gassaway,Steven G. Grinnell,Jaena Han,Michael Ansonoff,John E. Pintar,Jonathan A. Javitch,Dalibor Sames,René Hen +12 more
TL;DR: Interestingly, while tianeptine also produces many opiate-like behavioral effects such as analgesia and reward, it does not lead to tolerance or withdrawal, which points to the possibility that MOR and its downstream signaling cascades may be novel targets for antidepressant drug development.
Journal ArticleDOI
On the addictive power of gabapentinoids: a mini-review.
TL;DR: The view that gabapentinoids are quite rarely addictive in the general population is supported, however, in patients with a history of SUD, gabAPentinoids (notably pregabalin) should avoided or, if thought to be beneficial, administered with caution by using a strict prescription and therapy monitoring.
Journal ArticleDOI
Tianeptine Abuse and Dependence in Psychiatric Patients: A Review of 18 Case Reports in the Literature
TL;DR: Caution should be taken when considering the prescription of tianeptine to patients with prior history of substance abuse, and close monitoring for drug misuse is needed during the treatment period.
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