Journal ArticleDOI
Acupuncture and endorphins.
TLDR
A combination of the two frequencies produces a simultaneous release of all four opioid peptides, resulting in a maximal therapeutic effect, verified in clinical studies in patients with various kinds of chronic pain including low back pain and diabetic neuropathic pain.About:
This article is published in Neuroscience Letters.The article was published on 2004-05-06. It has received 718 citations till now. The article focuses on the topics: Chronic pain & Opioid peptide.read more
Citations
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Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture
Nanna Goldman,Michael Chen,Takumi Fujita,Qiwu Xu,Weiguo Peng,Wei Liu,Tina K Jensen,Yong Pei,Fushun Wang,Xiaoning Han,Jiang-Fan Chen,Jurgen Schnermann,Takahiro Takano,Lane K. Bekar,Kim Tieu +14 more
TL;DR: Observations indicate that adenosine mediates the effects of acupuncture and that interfering withAdenosine metabolism may prolong the clinical benefit of acupuncture.
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Acupuncture treatment for pain: systematic review of randomised clinical trials with acupuncture, placebo acupuncture, and no acupuncture groups
TL;DR: A small analgesic effect of acupuncture was found, which seems to lack clinical relevance and cannot be clearly distinguished from bias, whether needling at acupuncture points, or at any site, reduces pain independently of the psychological impact of the treatment ritual is unclear.
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Acupuncture – a critical analysis
TL;DR: Some findings are encouraging but others suggest that its clinical effects mainly depend on a placebo response, and acupuncture remains steeped in controversy.
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Acupuncture analgesia: I. The scientific basis.
TL;DR: Current biophysiological and imaging studies that explore the mechanisms of acupuncture analgesia are examined, allowing scientists to better evaluate the chain of events that occur after acupuncture-induced stimulation.
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Acupuncture analgesia: areas of consensus and controversy.
TL;DR: This article focuses on summarizing the areas of consensus and the controversy stemming from research published in the recent decades on the clinical efficacy and the basic mechanisms of acupuncture.
References
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A potent and selective endogenous agonist for the mu-opiate receptor.
TL;DR: The discovery and isolation from brain of a peptide, endomorphin-1 (Tyr-Pro-Trp-Phe-NH2), which has the highest specificity and affinity for the µ receptor of any endogenous substance so far described and they maybe natural ligands for this receptor.
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Dynorphin is a specific endogenous ligand of the kappa opioid receptor.
TL;DR: In the guinea pig ileum myenteric plexus--longitudinal muscle preparation, dynorphin-(1--13) and the prototypical kappa agonist ethylketocyclazocine had equally poor sensitivity to naloxone antagonism and showed selective cross protection in receptor inactivation experiments with the alkylating antagonist beta-chlornaltrexamine.
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Antagonism of acupuncture analgesia in man by the narcotic antagonist naloxone.
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Naloxone blockade of acupuncture analgesia: endorphin implicated.
Bruce Pomeranz,Daryl Chiu +1 more
TL;DR: Electroacupuncture in awake mice produced analgesia to noxious heat stimuli causing a 54% increase in latency to squeak, implying that endorphin is released at a low basal rate in “normal” mice, and at a much higher rate during acupuncture.