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Adenosine receptor-mediated inhibition of rat cerebral cortical adenylate cyclase by a GTP-dependent process.
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In this article, N6-Phenylisopropyladenosine and other analogues of adenosine are potent inhibitors of adenylate cyclase in a particulate preparation of rat cerebral cortex.Abstract:
Adenosine analogues inhibit rat cerebral cortical adenylate cyclase by a receptor-mediated GTP-dependent process. N6-Phenylisopropyladenosine and other analogues of adenosine are potent inhibitors (Ki values of 10-100 nM) of adenylate cyclase in a particulate preparation of rat cerebral cortex. The detection of such inhibitory effects is facilitated by the use of a deoxy ATP assay system. The inhibition is strictly dependent on GTP, is amplified by Na+ ions, and is antagonized by methylxanthines.read more
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