PatentDOI
Adiabatic pulses for wideband inversion and broadband decoupling
TLDR
In this article, an inversion pulse for wideband application is obtained from a simple nonlinear amplitude modulation wherein the amplitude is modulated in accord with A(t)=A 0 {1-| sin βt| n } and the entire pulse is frequency modulated such that the phase varies as φ(t) =φ 0 + 1/2 kt 2About:
This article is published in Journal of Magnetic Resonance, Series A.The article was published on 1996-07-26. It has received 538 citations till now. The article focuses on the topics: Amplitude modulation & Amplitude.read more
Citations
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Journal ArticleDOI
35Cl solid-state NMR spectroscopy of HCl pharmaceuticals and their polymorphs in bulk and dosage forms
Andrew M. Namespetra,David Hirsh,Marcel P. Hildebrand,Anthony R. Sandre,Hiyam Hamaed,Jeremy M. Rawson,Robert W. Schurko +6 more
TL;DR: In this paper, the authors demonstrate the use of 35Cl solid-state NMR (SSNMR) at moderate (9.4 T) and high (21.1 T) magnetic field strengths for the structural fingerprinting of hydrochloride (HCl) salts of active pharmaceutical ingredients (APIs) and several polymorphs, in both bulk and dosage forms.
Journal ArticleDOI
Side chain dynamics in unfolded protein states: an NMR based 2H spin relaxation study of Δ131Δ
TL;DR: This is the first time that side chain dynamics in an unfolded state have been studied in detail by NMR, and a motional model is proposed to estimate chi(1) torsion angle fluctuations, sigma(chi)()1, of Val and Thr residues on the basis of the backbone and side chain order parameters.
Journal ArticleDOI
NMR method for measuring carbon-13 isotopic enrichment of metabolites in complex solutions.
Ian A. Lewis,Ryan H. Karsten,Mark E. Norton,Marco Tonelli,William M. Westler,John L. Markley +5 more
TL;DR: A new pulse sequence, isotope-edited total correlation spectroscopy (ITOCSY), that filters two-dimensional 1H−1H NMR spectra from 12C- and 13C-containing molecules into separate, quantitatively equivalent spectra is developed.
Journal ArticleDOI
Testing the sensitivity limits of 33S NMR: an ultra-wideline study of elemental sulfur
TL;DR: Recently developed ultra-wideline techniques were used to record the spectrum from a>99.9% enriched sample of elemental sulfur, resulting in the largest (33)S quadrupolar coupling constant yet measured by solid-state NMR (C(Q)=43.3 MHz).
References
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PatentDOI
Methods of, and apparatus for, proton decoupling in nuclear magnetic resonance spectroscopy
TL;DR: In this paper, a radio-frequency pulse is tuned to the frequency of the nuclear species, such as 1 H, to be decoupled or saturated and has a bandwidth adjusted to correspond to the entire chemical shift spectrum, minimizing the amount of radiofrequency power transmitted into a volume of the irradiated sample.
Patent
RF pulse cascade for the generation of NMR spectra
TL;DR: In this article, a method for generating a spectrum of NMR signals with rectangular characteristic in the frequency space by radiating a sequence of RF pulses onto a sample in the homogeneous magnetic field is presented.
PatentDOI
Method and apparatus for broadband decoupling in nuclear magnetic resonance with chirp pulses
Riqiang Fu,Geoffrey Bodenhausen +1 more
TL;DR: In this article, the authors proposed a method for broadband decoupling in nuclear magnetic resonance with chirp and other RF pulses, where the sample is placed in a static field, and a first cycle of chirps pulses are generated, followed by a second cycle of pulses generated by a supercycle of the first and second cycles.
Patent
Method for exciting transverse magnetization in magnetic resonance
TL;DR: In this article, a method for exciting transverse magnetization by irradiating a nuclear spin system subjected to a constant magnetic field with a frequency-modulated rf-pulse ("chirp"-pulse) and with a further frequency-modified rfpulse (further chirppulse), for refocusing the magnetization, is characterized in that the rf pulse-(P1) and the further pulse (P2) overlap each other in time at least partially.
PatentDOI
Method for determining optimized radio-frequency pulse shapes for selective excitation in magnetic resonance spectroscopy and imaging
TL;DR: In this paper, a spin system with a frequency-selective radio-frequency (RF) pulse was used for magnetic resonance spectroscopy and imaging, and the shape of the pulse was optimized.
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